Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2,4- dialkylpyridine derivatives as selective A3 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 42, Issue 4, 1999, Pages 706-721

  Li, An Hu ^a   Moro, Stefano ^a   Forsyth, Nancy ^a   Melman, Neli ^a   Ji, Xiao Duo ^a   Jacobson, Kenneth A ^a,b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Molecular Recognition Section   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 THIOLACTONE; ADENOSINE RECEPTOR BLOCKING AGENT; CAFFEINE; DIHYDROPYRIDINE DERIVATIVE; THEOPHYLLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; CEREBRAL CORTEX; CHO CELLS; CRICETINAE; HUMANS; LIGANDS; MICE; MODELS, MOLECULAR; NEOSTRIATUM; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033602131     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980550w     Document Type: Article

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