Nucleoside modification and concerted mutagenesis of the human A 3 adenosine receptor to probe interactions between the 2-position of adenosine analogs and Gln167 in the second extracellular loop

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 10-12, 2005, Pages 1507-1517

  Duong, Heng T ^a   Gao, Zhan Guo ^a   Jacobson, Kenneth A ^a,b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Extracellular loop; G protein coupled receptor; Mutagenesis; Neoceptor; Purines

Indexed keywords

9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR ANTAGONIST; ADENOSINE DERIVATIVE; ALANINE; AMINE; ARGININE; CARBOXYLIC ACID DERIVATIVE; FUNCTIONAL GROUP; GLUTAMIC ACID; GLUTAMINE; NUCLEOSIDE DERIVATIVE; TRIAZOLOQUINAZOLINE DERIVATIVE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING ASSAY; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; MOLECULAR PROBE; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; SURFACE CHARGE; WILD TYPE;

ADENOSINE; AMINO ACID SUBSTITUTION; CELL LINE; GLUTAMINE; HUMANS; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN BINDING; RECEPTORS, PURINERGIC P1;

EID: 29244464712     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770500265778     Document Type: Article

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