Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation

Arthritis and Rheumatism

Volumn 39, Issue 6, 1996, Pages 923-930

  Boyle, David L ^a   Sajjadi, Fereydoun G ^a   Firestein, Gary S ^a,b  

^a Gensia Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR; COLLAGENASE; CYCLIC AMP; FORSKOLIN; INTERLEUKIN 1; STROMELYSIN;

ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE;

ADENOSINE; ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); BASE SEQUENCE; CELLS, CULTURED; COLLAGENASES; CYCLIC AMP; HUMANS; INTERLEUKIN-1; MATRIX METALLOPROTEINASE 3; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; RECEPTORS, PURINERGIC P1; RNA, MESSENGER; SYNOVIAL MEMBRANE; TIME FACTORS;

EID: 0029896521     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390608     Document Type: Article

References (27)

1. Firestein GS: Synovitis and pannus. In, Rheumatology. First edition. Edited by J Klippel, P Dieppe. St. Louis, Mosby, 1994
2. Woessner JF Jr: Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5:2145-2154, 1991
3. Firestein GS, Paine MM, Boyle DL: Mechanisms of methotrexate action in rheumatoid arthritis: selective decrease in synovial collagenase gene expression. Arthritis Rheum 37:193-200, 1994
4. Cronstein BN, Eberle MA, Gruber HE, Levin RI: Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. Proc Natl Acad Sci U S A 88:2441-2445, 1991
5. Asako H, Wolf RE, Granger DN: Leukocyte adherence in rat mesenteric venules: effects of adenosine and methotrexate. Gastroenterology 104:31-37, 1993
6. Cronstein BN, Naime D, Ostad E: The anti-inflammatory mechanism of low-dose methotrexate: increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. J Clin Invest 92:2675-2682, 1993
7. Alvaro-Gracia JM, Zvaifler NJ, Firestein GS: Cytokines in chronic inflammatory arthritis. V. Mutual antagonism between IFN-gamma and TNF-alpha on HLA-DR expression, proliferation, collagenase production, and GM-CSF production by rheumatoid arthritis synoviocytes. J Clin Invest 86:1790-1798, 1990
8. Taylor DJ, Cheung NT, Dawes PT: Increased serum proMMP-3 in inflammatory arthritides: a potential indicator of synovial inflammatory monokine activity. Ann Rheum Dis 53:768-772, 1994
9. Lees M, Taylor DJ, Woolley DE: Mast cell proteinases activate precursor forms of collagenase and stromelysin, but not gelatinases A and B. Eur J Biochem 223:171-177, 1994
10. Firestein GS, Paine MM, Littman BH: Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium: quantitative analysis and effect of intraarticular corticosteroids. Arthritis Rheum 34:1094-1105, 1991
11. Firestein GS, Boyle DL, Yu C, Paine MM, Whisenand TD, Zvaifler NJ, Arend WP: Synovial interleukin-1 receptor antagonist and interleukin-1 balance in rheumatoid arthritis. Arthritis Rheum 37:644-652, 1994
12. Pierce KD, Furlong TJ, Selbie LA, Shine J: Molecular cloning and expression of an adenosine A2b receptor from human brain. Biochem Biophys Res Commun 187:86-93, 1992
13. McCachren S, Haynes BF, Niedel JE: Localization of collagenase mRNA in rheumatoid arthritis synovium by in situ hybridization histochemistry. J Clin Immunol 10:19-27, 1990
14. Gravallese EM, Darling JM, Ladd AL, Katz JN, Glimcher LH: In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium. Arthritis Rheum 34:1076-1084, 1991
15. Weinblatt ME, Kaplan H, Germain BF, Block S, Solomon SD, Merriman RC, Wolfe F, Wall B, Anderson L, Gall E, Torretti D, Weissman B: Methotrexate in rheumatoid arthritis: a five-year prospective multicenter study. Arthritis Rheum 37:1492-1498, 1994
16. MacNaul KL, Chartrain N, Lark M, Tocci MJ, Hutchinson NI: Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts: synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression. J Biol Chem 265:17238-17245, 1990
17. Brackett LE, Daly JW: Functional characterization of the A2b adnosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol 47:801-814, 1994
18. Rivkees SA, Reppert SM: RFL9 encodes an A2b-adenosine receptor. Mol Endocrinol 6:1598-1604, 1992
19. Corcoran ML, Stetler-Stevenson WG, DeWitt DL, Wahl LM: Effect of cholera toxin and pertussis toxin on prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinase production by human monocytes. Arch Biochem Biophys 310:481-488, 1994
20. Clohisy JC, Connolly TJ, Bergman KD, Quinn CO, Partridge NC: Prostanoid-induced expression of matrix metalloproteinase-1 messenger ribonucleic acid in rat osteosarcoma cells. Endocrinology 135:1447-1454, 1994
21. Salvatori R, Guidon PT Jr, Rapuano BE, Bockman RS: Prostaglandin E1 inhibits collagenase gene expression in rabbit synoviocytes and human fibroblasts. Endocrinology 131:21-28, 1992
22. McCarthy GM, Cheung HS: The role of cyclic-3′,5′-adenosine monophosphate in prostaglandin-mediated inhibition of basic calcium phosphate crystal-induced mitogenesis and collagenase induction in cultured human fibroblasts. Biochim Biophys Acta 1226:97-104, 1994
23. Takahashi S, Ito A, Nagino M, Mori Y, Xie B, Nagase H: Cyclic adenosine 3′,5′-monophosphate suppresses interleukin 1-induced synthesis of matrix metalloproteinases but not of tissue inhibitor of metalloproteinases in human uterine cervical fibroblasts. J Biol Chem 266:19894-19899, 1991
24. DiBattista JA, Pelletier JP, Zafarullah M, Fujimoto N, Obata K, Martel-Pelletier J: Coordinate regulation of matrix metalloproteases and tissue inhibitor of metalloproteinase expression in human synovial fibroblasts. J Rheumatol 22 (suppl 43): 123-128, 1995
25. Firestein GS, Bullough DA, Erion MD, Jimenez R, Ramirez-Weinhouse M, Barankiewicz J, Smith CW, Gruber HE, Mullane KM: Inhibitor of neutrophil adhesion by adenosine and an adenosine kinase inhibitor: the role of selectins. J Immunol 154:326-334, 1995
26. Rosengren S, Bong G, Firestein GS: Anti-inflammatory effects of an adenosine kinase inhibitor: decreased neutrophil accumulation and vascular leakage. J Immunol 154:5444-5451, 1995
27. Cronstein B, Naime D, Firestein GS: The anti-inflammatory effects of an adenosine kinase inhibitor are mediated by adenosine. Arthritis Rheum 38:1040-1045, 1995