2-Aryl-8-chloro-1,2,4-triazolo[1,5-a]quinoxalin-4-amines as highly potent A 1 and A 3 adenosine receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 3, 2005, Pages 705-715

  Catarzi, Daniela ^a   Colotta, Vittoria ^a   Varano, Flavia ^a   Calabri, Francesca Romana ^a   Lenzi, Ombretta ^a   Filacchioni, Guido ^a   Trincavelli, Letizia ^b   Martini, Claudia ^b   Tralli, Andrea ^c   Montopoli, Christian ^c   Moro, Stefano ^c  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Perinatology Child Hlth Univ S   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Adenosine receptor antagonists; G Protein coupled receptor ligands; Triazoloquinoxalines; Tricyclic heteroaromatic systems

Indexed keywords

8 CHLORO 2 (4 METHOXYPHENYL) 1,2,4 TRIAZOLO[1,5 A]QUINOXALIN 4 ACETYLAMINE; 8 CHLORO 2 (4 METHOXYPHENYL) 1,2,4 TRIAZOLO[1,5 A]QUINOXALIN 4 AMINE; 8 CHLORO 2 (4 METHOXYPHENYL) 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 BENZOYLAMINE; 8 CHLORO 2 (4 METHOXYPHENYL) 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 PROPIONYLAMINE; 8 CHLORO 2 (4 METHOXYPHENYL) 1,2,4 TRIAZOLO[1,50 A]QUINOXALINE 4 PHENYLACETYLAMINE; 8 CHLORO 2 (4 METHOXYPHENYL) 1,2,4 TRIAZOLO[1,50 A]QUINOXALINE 4 PHENYLCARBAMOYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALIN 4 ACETYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALIN 4 AMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 BENZOYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 BENZYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 BENZYLCARBAMOYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 CYCLOHEXYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 CYCLOPENTYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 PHENYLACETYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 PHENYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 PHENYLCARBAMOYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 PHENYLETHYLAMINE; 8 CHLORO 2 PHENYL 1,2,4 TRIAZOLO[1,5 A]QUINOXALINE 4 PROPIONYLAMINE; ADENOSINE A1 RECEPTOR; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; HYDROGEN BOND; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; RADIOASSAY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; CATTLE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; QUINOXALINES; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP;

BOVINAE;

EID: 19944429549     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.10.050     Document Type: Article

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