Exploring the molecular basis of selectivity in A1 adenosine receptors agonists: A case study

Journal of Computer-Aided Molecular Design

Volumn 17, Issue 1, 2003, Pages 39-51

  Giordanetto, Fabrizio ^a   Fossa, Paula ^b   Menozzi, Giulia ^b   Schenone, Silvia ^b   Bondavalli, Francesco ^b   Ranise, Angelo ^b   Mosti, Luisa ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Adenosine receptor: AR; Adenylate cyclase: AC; G protein coupled receptors: GPCRs; Transmembrane domain: TM

Indexed keywords

ACTIVATION ANALYSIS; BIOMOLECULES; HYDROGEN BONDS; HYDROPHOBICITY;

ADENOSINE RECEPTOR; ADENOSINE RECEPTOR: AR; ADENYLATE CYCLASE; ADENYLATE CYCLASE: AC; G PROTEIN COUPLED RECEPTORS; G-PROTEIN-COUPLED RECEPTOR: GPCR; MOLECULAR BASIS; TRANS-MEMBRANE DOMAINS; TRANSMEMBRANE DOMAIN; TRANSMEMBRANE DOMAIN: TM;

LIGANDS;

2 CHLORO 6 N CYCLOPENTYLADENOSINE; 4 [7 [[1 [(3 CHLORO 2 THIENYL)METHYL]PROPYL]AMINO] 3H IMIDAZO[4,5 B]PYRIDIN 3 YL] N ETHYL 2,3 DIHYDROXYCYCLOPENTANECARBOXAMIDE; 6 N CYCLOHEXYL 2' O METHYLADENOSINE; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A1 RECEPTOR; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR AFFECTING AGENT; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; ALANINE; AMIDE; AMINO ACID; AZ 1081; BN 063; DORIDOSINE; DRUG RECEPTOR; GUANOSINE DERIVATIVE; NITROGEN; NNC 210136; NNC 210147; NNC 901515; PURINE NUCLEOSIDE; RECEPTOR SUBTYPE; RG 14178; RG 14202; RHODOPSIN; RIBOSE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UP 202 32;

ANALYTIC METHOD; ARTICLE; BIOCHEMISTRY; CARDIOVASCULAR DISEASE; CASE STUDY; CATTLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG RESEARCH; DRUG SELECTIVITY; DRUG STRUCTURE; GENE MUTATION; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR INTERACTION; MOLECULAR MODEL; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION;

EID: 0041695555     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1024530029922     Document Type: Article

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