Modulation of adenosine receptor affinity and intrinsic efficacy in adenine nucleosides substituted at the 2-position

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 11, 2004, Pages 2995-3007

  Ohno, Michihiro ^a   Gao, Zhan Guo ^a   Van Rompaey, Philippe ^b   Tchilibon, Susanna ^a   Kim, Soo Kyung ^a   Harris, Brian A ^a   Gross, Ariel S ^a   Duong, Heng T ^a   Van Calenbergh, Serge ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b Lab voor Medicinale Chemie (FFW)   (Belgium)

Author keywords

Agonists; Antagonists; Binding; Cyclic AMP; GPCR; Molecular modeling; Purines

Indexed keywords

2 (2 AMINO 6 METHYLAMINOPURIN 9 YL) 5 HYDROXYMETHYLTETRAHYDROFURAN 3,4 DIOL; 2 (2 AMINOMETHYL 6 METHYLAMINOPURIN 9 YL) 5 HYDROXYMETHYLTETRAHYDROFURAN 3,4 DIOL; 2 (2 CYANO 6 METHYLAMINOPURIN 9 YL) 5 HYDROXYMETHYLTETRAHYDROFURAN 3,4 DIOL; 2 (6 METHYLAMINO 3 TRIFLUOROMETHYLPURIN 9 YL) 5 HYDROXYMETHYLTETRAHYDROFURAN 3,4 DIOL; 2 [2 CYANO 6 (3 IODOBENZYLAMINO)PURIN 9 YL] 5 HYDROXYMETHYLTETRAHYDROFURAN 3,4 DIOL; 2 [2 IODO 6 (3 IODOBENZYLAMINO)PURIN 9 YL] 5 HYDROXYMETHYLTETRAHYDROFURAN 3,4 DIOL; 2 [2 METHOXYCARBONYL 6 (3 IODOBENZYLAMINO)PURIN 9 YL] 5 HYDROXYMETHYLTETRAHYDROFURAN 3,4 DIOL; 2 [6 (3 IODOBENZYLAMINO) 2 TRIFLUOROMETHYLPURIN 9 YL] 5 HYDROXYMETHYLTETRAHYDROFURAN 3,4 DIOL; 9 (3,4 DIHYDROXY 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL) 6 (3 IODOBENZYLAMINO) 9H PURINE 2 CARBOXYLIC ACID 3 IODOBENZYLAMIDE; 9 (3,4 DIHYDROXY 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL) 6 (5 CHLORO 2 METHOXYBENZYLAMINO) 9H PURINE; 9 (3,4 DIHYDROXY 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL) 6 (5 CHLORO 2 METHOXYBENZYLAMINO) 9H PURINE 2 CARBONITRILE; 9 (3,4 DIHYDROXY 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL) 6 (5 CHLORO 2 METHOXYBENZYLAMINO) 9H PURINE 2 CARBOXYLIC ACID; 9 (3,4 DIHYDROXY 5 HYDROXYMETHYLTETRAHYDROFURAN 2 YL) 6 METHYLAMINO 9H PURINE 2 CARBOXAMIDINE; ADENINE DERIVATIVE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; CYCLIC AMP; CYCLOPROPANE DERIVATIVE; LIGAND; METHYL GROUP; NITRILE; NUCLEOSIDE; PHENYL GROUP; RHODOPSIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING SITE; DRUG EFFECT; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; MODULATION; SEQUENCE HOMOLOGY; STEREOCHEMISTRY;

ADENOSINE; BINDING SITES; DEOXYADENOSINES; HUMANS; MODELS, MOLECULAR; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2442507658     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.031     Document Type: Article

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