Synthesis, biological activity, and molecular modeling investigation of new pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as human A3 adenosine receptor antagonists

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 770-780

  Baraldi, Pier Giovanni ^a   Cacciari, Barbara ^a   Moro, Stefano ^b   Spalluto, Giampiero ^c   Pastorin, Giorgia ^c   Da Ros, Tatiana ^c   Klotz, Karl Norbert ^d   Varani, Katia ^a   Gessi, Stefania ^a   Borea, Pier Andrea ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR ANTAGONIST; PYRAZOLE DERIVATIVE; PYRAZOLO[4,3 E] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHO CELL; COMPUTER MODEL; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; MOLECULAR MODEL; STATISTICAL ANALYSIS;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; HUMANS; MODELS, MOLECULAR; PROTEIN STRUCTURE, SECONDARY; PYRIMIDINES; RADIOLIGAND ASSAY; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0037075142     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0109614     Document Type: Article

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