A3 adenosine receptor as a target for cancer therapy

Anti-Cancer Drugs

Volumn 13, Issue 5, 2002, Pages 437-443

  Fishman, Pnina ^a   Bar Yehuda, Sara ^a   Madi, Lea ^a   Cohn, Ilan ^a  

^a RABIN MEDICAL CENTER   (Israel)

Author keywords

A3 adenosine receptor; Adenosine; Cancer therapy; Myeloprotection

Indexed keywords

ADENOSINE; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; ADENYLATE CYCLASE; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3BETA; GRANULOCYTE COLONY STIMULATING FACTOR; PROTEIN KINASE B; WNT PROTEIN; ADENOSINE RECEPTOR; AKT1 PROTEIN, HUMAN; ALKYLATING AGENT; DRUG DERIVATIVE; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE;

ANTINEOPLASTIC ACTIVITY; CANCER INHIBITION; CANCER THERAPY; COLON CARCINOMA; DRUG BIOAVAILABILITY; DRUG MECHANISM; ENZYME INHIBITION; LYMPHOMA; MELANOMA; NONHUMAN; PRIORITY JOURNAL; PROSTATE CARCINOMA; REVIEW; TUMOR DIFFERENTIATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; DRUG POTENTIATION; HUMAN; METABOLISM; MOUSE; NEOPLASM; ORAL DRUG ADMINISTRATION; SIGNAL TRANSDUCTION;

ADENOSINE; ADMINISTRATION, ORAL; ANIMAL; ANTINEOPLASTIC AGENTS, ALKYLATING; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMAN; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASMS; PROTO-ONCOGENE PROTEINS; RECEPTORS, PURINERGIC P1; SIGNAL TRANSDUCTION; ANIMALS; HUMANS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ADENOSINE A3;

EID: 0035987056     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200206000-00001     Document Type: Review

References (23)

1. Muscle cells produce a low molecular weight factor with anti-cancer activity
2. Oral administration of muscle derived small molecules inhibits tumor spread while promoting normal cell growth in mice
3. Adenosine, other low molecular weight factors released by muscle cells inhibit tumor cell growth
4. Resistance of muscle to tumor metastases: A role for A3 adenosine receptor agonists
5. A3 adenosine receptors: Design of selective ligands and therapeutic prospects
6. Adenosine acts as an inhibitor of lymphoma cell growth: A major role for the A3 adenosine receptor
7. Adenosine acts as a chemoprotective agent by stimulating G-CSF production: A role for A1 and A3 adenosine receptors
8. The role of receptor structure in determining adenosine receptor activity
9. Adenosine receptors: New opportunities for future drugs
10. Agonist-induced internalization and recycling of the human A3 adenosine receptors: Role in receptor desensitization and resensitization
11. Identification of threonine residues controlling the agonist-dependent phosphorylation and desensitization of the rat A(3) adenosine receptor
12. Induction of multiple effects on adenylyl cyclase regulation by chronic activation of the human A3 adenosine receptor
13. Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells
14. Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell line
15. Pharmacological characterization adenosine receptors in PGT-beta mouse pineal gland tumour cells
16. Overexpression of a3 adenosine receptors in smooth, cardiac, and skeletal muscle is lethal to embryos
17. Adenosine and other low molecular weight factors released by muscle cells inhibit tumor cell growth: Possible explanation for the rarity of metastases in muscle
18. Evidence for the involvement of wnt signaling pathway in IB-MECA mediated suppression of melanoma cells
19. Right thing at a wrong time? Adenosine A3 receptors and cerebro-protection in stroke
20. Evidence that the adenosine A3 receptor may mediate the protection afforded by preconditioning in the isolated rabbit heart
21. Activation of A3 adenosine receptor protects against doxorubicin-induced cardiotoxicity
22. A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists
23. Adenosine A3 receptor agonists inhibit murine macrophage tumor necrosis factor-alpha production in vitro and in vivo