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Volumn 8, Issue 1, 2008, Pages 53-75

Inhibitors of cyclin dependent kinases: Useful targets for cancer treatment

Author keywords

Anticancer agents; Apoptosis; Cell cycle; CKIs; Cyclin dependent kinase; Small molecule inhibitors

Indexed keywords

7 HYDROXYSTAUROSPORINE; ACETOPHTHALIDIN; ADENOSINE TRIPHOSPHATE; ALOISINE; ANTINEOPLASTIC AGENT; BUTYROLACTONE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVONOID; HYDRAZONE DERIVATIVE; HYMENIALDISINE; INDIRUBIN; INDISULAM; INDOLE DERIVATIVE; PAULLONE; PAULLONE DERIVATIVE; PHTHALIDE DERIVATIVE; PURINE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE; SELENIUM DERIVATIVE; STAUROSPORINE; STAUROSPORINE DERIVATIVE; THIAZOLE DERIVATIVE; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

EID: 39049126024     PISSN: 15680096     EISSN: None     Source Type: Journal    
DOI: 10.2174/156800908783497131     Document Type: Review
Times cited : (78)

References (196)
  • 1
    • 0004099105 scopus 로고
    • Foye, W. O. Ed, American Chemical Society: Washington DC
    • Foye, W. O. Ed. Cancer Chemotherapeutic Agent American Chemical Society: Washington DC, 1995.
    • (1995) Cancer Chemotherapeutic Agent
  • 2
    • 0028931265 scopus 로고
    • Principles of CDK Regulation
    • Morgan, D. O. Principles of CDK Regulation. Nature 1995, 374(6518), 131-134.
    • (1995) Nature , vol.374 , Issue.6518 , pp. 131-134
    • Morgan, D.O.1
  • 3
    • 0037032835 scopus 로고    scopus 로고
    • The Protein Kinase Complement of the Human Genome
    • Manning, G.; Whyte, D. B.; Martinez, R.; Hunter, T.; Sudarsanan, S. The Protein Kinase Complement of the Human Genome. Science 2002, 298(5600), 1912-1934.
    • (2002) Science , vol.298 , Issue.5600 , pp. 1912-1934
    • Manning, G.1    Whyte, D.B.2    Martinez, R.3    Hunter, T.4    Sudarsanan, S.5
  • 4
    • 0035413616 scopus 로고    scopus 로고
    • Cyclin-Dependent Kinases
    • Harper, J. W.; Adams, P. D. Cyclin-Dependent Kinases. Chem. Rev. 2001, 101(8), 2511-2526.
    • (2001) Chem. Rev , vol.101 , Issue.8 , pp. 2511-2526
    • Harper, J.W.1    Adams, P.D.2
  • 5
    • 0027938209 scopus 로고
    • Cyclins and Cancer. II: Cyclin D and CDK Inhibitors Come of Age
    • Hunter, T.; Pines, J. Cyclins and Cancer. II: Cyclin D and CDK Inhibitors Come of Age. Cell 1994, 79(4), 573-582.
    • (1994) Cell , vol.79 , Issue.4 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 6
    • 33746827430 scopus 로고    scopus 로고
    • The Purines: Potent and Versatile Small Molecule Inhibitors and Modulators of Key Biological Targets
    • Legraverend, M.; Grierson, D. S. The Purines: Potent and Versatile Small Molecule Inhibitors and Modulators of Key Biological Targets. Bioorg. Med. Chem. 2006, 14(12), 3987-4006.
    • (2006) Bioorg. Med. Chem , vol.14 , Issue.12 , pp. 3987-4006
    • Legraverend, M.1    Grierson, D.S.2
  • 7
    • 0038052805 scopus 로고    scopus 로고
    • The Cell Cycle: A Review of Regulation, Deregulation and Therapeutic Targets in Cancer
    • Vermeulen, K.; Van Bockstaele, D. R.; Berneman, Z. N. The Cell Cycle: a Review of Regulation, Deregulation and Therapeutic Targets in Cancer. Cell Prolif. 2003, 36(3), 131-149.
    • (2003) Cell Prolif , vol.36 , Issue.3 , pp. 131-149
    • Vermeulen, K.1    Van Bockstaele, D.R.2    Berneman, Z.N.3
  • 8
    • 0038245253 scopus 로고    scopus 로고
    • Small Molecules as Inhibitors of Cyclin-Dependent Kinases
    • Huwe, A.; Mazitschek, R.; Giannis, A. Small Molecules as Inhibitors of Cyclin-Dependent Kinases. Angew. Chem., Int. Ed. 2003, 42(19), 2122-2138.
    • (2003) Angew. Chem., Int. Ed , vol.42 , Issue.19 , pp. 2122-2138
    • Huwe, A.1    Mazitschek, R.2    Giannis, A.3
  • 9
    • 1642323740 scopus 로고    scopus 로고
    • Protein Kinase Inhibitors: Insights into Drug Design from Structure
    • Noble, M. E. M.; Endicott, J. A.; Johnson, L. N. Protein Kinase Inhibitors: Insights into Drug Design from Structure. Science 2004, 303(5665), 1800-1805.
    • (2004) Science , vol.303 , Issue.5665 , pp. 1800-1805
    • Noble, M.E.M.1    Endicott, J.A.2    Johnson, L.N.3
  • 10
    • 0035413617 scopus 로고    scopus 로고
    • Chemical Inhibitors of Protein Kinases
    • Bridges, A. J. Chemical Inhibitors of Protein Kinases. Chem. Rev. 2001, 101(8), 2541-2571.
    • (2001) Chem. Rev , vol.101 , Issue.8 , pp. 2541-2571
    • Bridges, A.J.1
  • 11
    • 1642412825 scopus 로고    scopus 로고
    • Inhibitors of Protein Kinase Signaling Pathways: Emerging Therapies for Cardiovascular Disease
    • Force, T.; Kuida, K.; Namchuk, M.; Parang, K.; Kyriakis, J. M. Inhibitors of Protein Kinase Signaling Pathways: Emerging Therapies for Cardiovascular Disease. Circulation 2004, 109, 1196-1205.
    • (2004) Circulation , vol.109 , pp. 1196-1205
    • Force, T.1    Kuida, K.2    Namchuk, M.3    Parang, K.4    Kyriakis, J.M.5
  • 13
    • 0037392942 scopus 로고    scopus 로고
    • The Specificities of Protein Kinase Inhibitors: An Update
    • Bain, J.; McLauchlan, H.; Elliott, M.; Cohen, P. The Specificities of Protein Kinase Inhibitors: an Update. Biochem. J. 2003, 371(Pt. 1), 199-204.
    • (2003) Biochem. J , vol.371 , Issue.PART. 1 , pp. 199-204
    • Bain, J.1    McLauchlan, H.2    Elliott, M.3    Cohen, P.4
  • 14
    • 10844242972 scopus 로고    scopus 로고
    • Loop Flexibility and Solvent Dynamics as Determinants for the Selective Inhibition of Cyclin-Dependent Kinase 4: Comparative Molecular Dynamics Simulation Studies of CDK2 and CDK4
    • Park, H.; Yeom, M. S.; Lee, S. Loop Flexibility and Solvent Dynamics as Determinants for the Selective Inhibition of Cyclin-Dependent Kinase 4: Comparative Molecular Dynamics Simulation Studies of CDK2 and CDK4. ChemBioChem 2004, 5(12), 1662-1672.
    • (2004) ChemBioChem , vol.5 , Issue.12 , pp. 1662-1672
    • Park, H.1    Yeom, M.S.2    Lee, S.3
  • 15
    • 0035920248 scopus 로고    scopus 로고
    • Crystallographic Approach to Identification of Cyclin-Dependent Kinase 4 (CDK4)-Specific Inhibitors by Using CDK4 Mimic CDK2 Protein
    • Ikuta, M.; Kamata, K.; Fukasawa, K.; Honma, T.; Machida, T.; Hirai, H.; Suzuki-Takahashi, I.; Hayama, T.; Nishimura, S. Crystallographic Approach to Identification of Cyclin-Dependent Kinase 4 (CDK4)-Specific Inhibitors by Using CDK4 Mimic CDK2 Protein. J. Biol. Chem. 2001, 276(29), 27548-27554.
    • (2001) J. Biol. Chem , vol.276 , Issue.29 , pp. 27548-27554
    • Ikuta, M.1    Kamata, K.2    Fukasawa, K.3    Honma, T.4    Machida, T.5    Hirai, H.6    Suzuki-Takahashi, I.7    Hayama, T.8    Nishimura, S.9
  • 16
    • 0034642532 scopus 로고    scopus 로고
    • Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation
    • Sielecki, T. M.; Boylan, J. F.; Benfield, P. A.; Trainor, G. L. Cyclin-Dependent Kinase Inhibitors: Useful Targets in Cell Cycle Regulation. J. Med. Chem. 2000, 43(1), 1-18.
    • (2000) J. Med. Chem , vol.43 , Issue.1 , pp. 1-18
    • Sielecki, T.M.1    Boylan, J.F.2    Benfield, P.A.3    Trainor, G.L.4
  • 17
    • 0032410285 scopus 로고    scopus 로고
    • Cip/Kip Cyclin-Dependent Kinase Inhibitors: Brakes of the Cell Cycle Engine During Development
    • Nakayama, K.; Nakayama K. Cip/Kip Cyclin-Dependent Kinase Inhibitors: Brakes of the Cell Cycle Engine During Development. Bioessays 1998, 20(12), 1020-1029.
    • (1998) Bioessays , vol.20 , Issue.12 , pp. 1020-1029
    • Nakayama, K.1    Nakayama, K.2
  • 18
    • 33748855626 scopus 로고    scopus 로고
    • Methylation of INK4 and CIP/KIP Families of Cyclin-Dependent Kinase Inhibitor in Chronic Lymphocytic Leukaemia in Chinese Patients
    • Chim, C. S.; Fung, T. K.; Wong, K. F.; Lau, J. S.; Law, M.; Liang, R. Methylation of INK4 and CIP/KIP Families of Cyclin-Dependent Kinase Inhibitor in Chronic Lymphocytic Leukaemia in Chinese Patients. J. Clin. Pathol. 2006, 59(9), 921-926.
    • (2006) J. Clin. Pathol , vol.59 , Issue.9 , pp. 921-926
    • Chim, C.S.1    Fung, T.K.2    Wong, K.F.3    Lau, J.S.4    Law, M.5    Liang, R.6
  • 20
    • 0028072520 scopus 로고
    • Joining the Complex: Cyclin-Dependent Kinase Inhibitory Proteins and the Cell Cycle
    • Peter, M.; Herskowitz, I. Joining the Complex: Cyclin-Dependent Kinase Inhibitory Proteins and the Cell Cycle. Cell 1994, 79(2), 181-184.
    • (1994) Cell , vol.79 , Issue.2 , pp. 181-184
    • Peter, M.1    Herskowitz, I.2
  • 21
    • 0035024104 scopus 로고    scopus 로고
    • Cip/Kip Cell-Cycle Inhibitors: A Neuro-Oncological Perspective
    • Mainprize, T. G.; Taylor, M. D.; Rutka, J. T.; Dirks, P. B. Cip/Kip Cell-Cycle Inhibitors: a Neuro-Oncological Perspective. J. Neurooncol. 2001, 51(3), 205-218.
    • (2001) J. Neurooncol , vol.51 , Issue.3 , pp. 205-218
    • Mainprize, T.G.1    Taylor, M.D.2    Rutka, J.T.3    Dirks, P.B.4
  • 23
    • 33847780136 scopus 로고    scopus 로고
    • The Multiple Battles Fought by Anti-Apoptotic p21
    • Janicke, R. U.; Sohn, D.; Essmann, F.; Schulze-Osthoff, K. The Multiple Battles Fought by Anti-Apoptotic p21. Cell Cycle 2007, 6(4), 407-413.
    • (2007) Cell Cycle , vol.6 , Issue.4 , pp. 407-413
    • Janicke, R.U.1    Sohn, D.2    Essmann, F.3    Schulze-Osthoff, K.4
  • 25
    • 0028875086 scopus 로고
    • Evidence for Different Modes of Action of Cyclin Dependent Kinase Inhibitors: P15 and p16 Bind to Kinases, p21 and p27 Bind to Cyclins
    • Hall, M.; Bates, S.; Peters, G. Evidence for Different Modes of Action of Cyclin Dependent Kinase Inhibitors: p15 and p16 Bind to Kinases, p21 and p27 Bind to Cyclins. Oncogene 1995, 11(8), 1581-1588.
    • (1995) Oncogene , vol.11 , Issue.8 , pp. 1581-1588
    • Hall, M.1    Bates, S.2    Peters, G.3
  • 27
    • 0031127177 scopus 로고    scopus 로고
    • Cyclins, Cyclin-Dependent Kinases and Differentiation
    • Gao, C. Y.; Zalenka, P. S. Cyclins, Cyclin-Dependent Kinases and Differentiation. Bioessays 1997, 19(4), 307-315.
    • (1997) Bioessays , vol.19 , Issue.4 , pp. 307-315
    • Gao, C.Y.1    Zalenka, P.S.2
  • 30
    • 0028168242 scopus 로고
    • INK4B is a Potential Effector of TGFβ-Induced Cell Cycle Arrest
    • INK4B is a Potential Effector of TGFβ-Induced Cell Cycle Arrest. Nature 1994, 371(6494), 257-261.
    • (1994) Nature , vol.371 , Issue.6494 , pp. 257-261
    • Hannon, G.J.1    Beach, D.2
  • 31
    • 0029153609 scopus 로고
    • Kip/Cip and INK4 CDK Inhibitors Cooperate to Induce Cell Cycle Arrest in Response to TFGβ
    • Reynisdottir, I.; Polyak, K.; Iavarone, A.; Massague, J. Kip/Cip and INK4 CDK Inhibitors Cooperate to Induce Cell Cycle Arrest in Response to TFGβ. Genes Dev. 1995, 9(15), 1831-1845.
    • (1995) Genes Dev , vol.9 , Issue.15 , pp. 1831-1845
    • Reynisdottir, I.1    Polyak, K.2    Iavarone, A.3    Massague, J.4
  • 34
    • 0000863502 scopus 로고    scopus 로고
    • Structure-Based Inhibitor Design for CDK2, a Cell Cycle Controlling Protein Kinase
    • Kim, S. H. Structure-Based Inhibitor Design for CDK2, a Cell Cycle Controlling Protein Kinase. Pure Appl. Chem. 1998, 70(3), 555-565.
    • (1998) Pure Appl. Chem , vol.70 , Issue.3 , pp. 555-565
    • Kim, S.H.1
  • 35
    • 0020417379 scopus 로고
    • The Crystal and Molecular Structure of Staurosporine, a New Alkaloid from a Streptomyces Strain
    • Furusaki, A.; Hashiba, N.; Matsumoto, T.; Hirano, A.; Iwai, Y.; Omura, S. The Crystal and Molecular Structure of Staurosporine, a New Alkaloid from a Streptomyces Strain. Bull. Chem. Soc. Jpn. 1982, 55, 3681-3685.
    • (1982) Bull. Chem. Soc. Jpn , vol.55 , pp. 3681-3685
    • Furusaki, A.1    Hashiba, N.2    Matsumoto, T.3    Hirano, A.4    Iwai, Y.5    Omura, S.6
  • 36
    • 0030271304 scopus 로고    scopus 로고
    • Chemical Inhibitors of Cyclin-Dependent Kinases
    • Meijer, L. Chemical Inhibitors of Cyclin-Dependent Kinases. Trends Cell. Biol. 1996, 6(10), 393-397.
    • (1996) Trends Cell. Biol , vol.6 , Issue.10 , pp. 393-397
    • Meijer, L.1
  • 37
    • 0029417882 scopus 로고    scopus 로고
    • Meijer, L. Chemical Inhibitors of Cyclin-Dependent Kinases. In Progress in Cell Cycle Research; Meijer, L., Guidet, S., Tung, H. Y. L., Eds.; Plenum Press: New York, 1995, pp. 351-361.
    • Meijer, L. Chemical Inhibitors of Cyclin-Dependent Kinases. In Progress in Cell Cycle Research; Meijer, L., Guidet, S., Tung, H. Y. L., Eds.; Plenum Press: New York, 1995, pp. 351-361.
  • 38
    • 33745079557 scopus 로고    scopus 로고
    • Staurosporine-Induced Growth Inhibition of Glioma Cells is Accompanied by Altered Expression of Cyclins, CDKs and CDK Inhibitors
    • Harmalkar, M. N.; Shirsat, N. V. Staurosporine-Induced Growth Inhibition of Glioma Cells is Accompanied by Altered Expression of Cyclins, CDKs and CDK Inhibitors. Neurochem. Res. 2006, 31(5), 685-692.
    • (2006) Neurochem. Res , vol.31 , Issue.5 , pp. 685-692
    • Harmalkar, M.N.1    Shirsat, N.V.2
  • 39
    • 0035110776 scopus 로고    scopus 로고
    • UCN-01 Kyowa Hakko Kogyo Co.
    • Grosios, K. UCN-01 Kyowa Hakko Kogyo Co. Curr. Opin. Investig. Drugs 2001, 2(2), 287-297.
    • (2001) Curr. Opin. Investig. Drugs , vol.2 , Issue.2 , pp. 287-297
    • Grosios, K.1
  • 40
    • 26044483061 scopus 로고    scopus 로고
    • Inhibitors of Cyclin-Dependent Kinase Modulators for Cancer Therapy
    • Senderowicz, A. M. Inhibitors of Cyclin-Dependent Kinase Modulators for Cancer Therapy. Prog. Drug Res. 2005, 63, 183-206.
    • (2005) Prog. Drug Res , vol.63 , pp. 183-206
    • Senderowicz, A.M.1
  • 41
    • 0036675996 scopus 로고    scopus 로고
    • 7-Hydroxystaurosporine (UCN-01) and Ionizing Radiation Combine to Inhibit the Growth of Bcl-2-Overexpressing U937 Leukemia Cells through a Non-Apoptotic Mechanism
    • Cartee, L.; Sankala, H.; Davis, C.; Smith, R.; Maggio, S.; Lin, P. S.; Dent, P.; Grant, S. 7-Hydroxystaurosporine (UCN-01) and Ionizing Radiation Combine to Inhibit the Growth of Bcl-2-Overexpressing U937 Leukemia Cells through a Non-Apoptotic Mechanism. Int. J. Oncol. 2002, 21(2), 351-359.
    • (2002) Int. J. Oncol , vol.21 , Issue.2 , pp. 351-359
    • Cartee, L.1    Sankala, H.2    Davis, C.3    Smith, R.4    Maggio, S.5    Lin, P.S.6    Dent, P.7    Grant, S.8
  • 43
    • 0032775345 scopus 로고    scopus 로고
    • K252a Induces Cell Cycle Arrest and Apoptosis by Inhibiting Cdc2 and Cdc25c
    • Chin, L. S.; Murray, S. F.; Doherty, P. F.; Singh, S. K. K252a Induces Cell Cycle Arrest and Apoptosis by Inhibiting Cdc2 and Cdc25c. Cancer Invest. 1999, 17(6), 391-395.
    • (1999) Cancer Invest , vol.17 , Issue.6 , pp. 391-395
    • Chin, L.S.1    Murray, S.F.2    Doherty, P.F.3    Singh, S.K.4
  • 45
    • 0000314933 scopus 로고    scopus 로고
    • Staurosporine and ent-Staurosporine: The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles
    • Link, J. T.; Raghavan, S.; Gallant, M.; Danishefsky, S. J.; Chou, T. C.; Ballas, L. M. Staurosporine and ent-Staurosporine: The First Total Syntheses, Prospects for a Regioselective Approach, and Activity Profiles. J. Am. Chem. Soc. 1996, 118(12), 2825-2842.
    • (1996) J. Am. Chem. Soc , vol.118 , Issue.12 , pp. 2825-2842
    • Link, J.T.1    Raghavan, S.2    Gallant, M.3    Danishefsky, S.J.4    Chou, T.C.5    Ballas, L.M.6
  • 46
    • 0000714445 scopus 로고    scopus 로고
    • Structure-Activity Relationships in a Series of Substituted Indolocarbazoles: Topoisomerase I and Protein Kinase C Inhibition and Antitumoral and Antimicrobial Properties
    • Pereira, E. R.; Belin, L.; Sancelme, M.; Prudhomme, M.; Ollier, M.; Rapp, M.; Severe, D.; Riou, J. -F.; Fabbro, D.; Meyer, T. Structure-Activity Relationships in a Series of Substituted Indolocarbazoles: Topoisomerase I and Protein Kinase C Inhibition and Antitumoral and Antimicrobial Properties. J. Med. Chem. 1996, 39(22), 4471-4477.
    • (1996) J. Med. Chem , vol.39 , Issue.22 , pp. 4471-4477
    • Pereira, E.R.1    Belin, L.2    Sancelme, M.3    Prudhomme, M.4    Ollier, M.5    Rapp, M.6    Severe, D.7    Riou, J.-F.8    Fabbro, D.9    Meyer, T.10
  • 47
    • 0030665684 scopus 로고    scopus 로고
    • Design and Implementation of an Efficient Synthetic Approach to Pyranosylated Indolocarbazoles: Total Synthesis of (+)-RK286c, (+)-MLR-52, (+)-Staurosporine, and (-)-TAN-1030a
    • Wood, J. L.; Stoltz, B. M.; Goodman, S. N.; Onwueme, K. Design and Implementation of an Efficient Synthetic Approach to Pyranosylated Indolocarbazoles: Total Synthesis of (+)-RK286c, (+)-MLR-52, (+)-Staurosporine, and (-)-TAN-1030a. J. Am. Chem. Soc. 1997, 119(41), 9652-9661.
    • (1997) J. Am. Chem. Soc , vol.119 , Issue.41 , pp. 9652-9661
    • Wood, J.L.1    Stoltz, B.M.2    Goodman, S.N.3    Onwueme, K.4
  • 48
    • 11244272760 scopus 로고    scopus 로고
    • Survivin and p53 Modulate Quercetin-Induced Cell Growth Inhibition and Apoptosis in Human Lung Carcinoma Cells
    • Kuo, P. C.; Liu, H. F.; Chao, J. I. Survivin and p53 Modulate Quercetin-Induced Cell Growth Inhibition and Apoptosis in Human Lung Carcinoma Cells. J. Biol. Chem. 2004, 279(53), 55875-55885.
    • (2004) J. Biol. Chem , vol.279 , Issue.53 , pp. 55875-55885
    • Kuo, P.C.1    Liu, H.F.2    Chao, J.I.3
  • 49
    • 27644568638 scopus 로고    scopus 로고
    • Quercetin-Induced Growth Inhibition and Cell Death in Prostatic Carcinoma Cells (PC-3) are Associated with Increase in p21 and Hypophosphorylated Retinoblastoma Proteins Expression
    • Vijayababu, M. R.; Kanagaraj, P.; Arunkumar, A.; Ilangovan, R.; Aruldhas, M. M.; Arunakaran, J. Quercetin-Induced Growth Inhibition and Cell Death in Prostatic Carcinoma Cells (PC-3) are Associated with Increase in p21 and Hypophosphorylated Retinoblastoma Proteins Expression. J. Cancer Res. Clin. Oncol. 2005, 131(11), 765-771.
    • (2005) J. Cancer Res. Clin. Oncol , vol.131 , Issue.11 , pp. 765-771
    • Vijayababu, M.R.1    Kanagaraj, P.2    Arunkumar, A.3    Ilangovan, R.4    Aruldhas, M.M.5    Arunakaran, J.6
  • 50
    • 27944479558 scopus 로고    scopus 로고
    • Flavopiridol, an Inhibitor of Cyclin-Dependent Kinases, Induces Growth Inhibition and Apoptosis in Bladder Cancer Cells in vitro and in vivo
    • Wirger A.; Perabo F. G.; Burgemeister, S.; Haase, L.; Schmidt, D. H.; Doehn, C.; Mueller, S. C.; Jocham, D. Flavopiridol, an Inhibitor of Cyclin-Dependent Kinases, Induces Growth Inhibition and Apoptosis in Bladder Cancer Cells in vitro and in vivo. Anticancer Res. 2005, 25(6B), 4341-4347.
    • (2005) Anticancer Res , vol.25 , Issue.6 B , pp. 4341-4347
    • Wirger, A.1    Perabo, F.G.2    Burgemeister, S.3    Haase, L.4    Schmidt, D.H.5    Doehn, C.6    Mueller, S.C.7    Jocham, D.8
  • 51
    • 33749513203 scopus 로고    scopus 로고
    • Morris, D. G.; Bramwell, V. H.; Turcotte, R.; Figueredo, A. T.; Blackstein, M. E.; Verma, S.; Matthews, S.; Eisenhauer, E. A. A Phase II Study of Flavopiridol in Patients With Previously Untreated Advanced Soft Tissue Sarcoma. Sarcoma 2006, 1, 1-7.
    • Morris, D. G.; Bramwell, V. H.; Turcotte, R.; Figueredo, A. T.; Blackstein, M. E.; Verma, S.; Matthews, S.; Eisenhauer, E. A. A Phase II Study of Flavopiridol in Patients With Previously Untreated Advanced Soft Tissue Sarcoma. Sarcoma 2006, 1, 1-7.
  • 55
    • 0030812207 scopus 로고    scopus 로고
    • Cytotoxic Synergy Between Flavopiridol (NSC 649890, L86-8275) and Various Antineoplastic Agents: The Importance of Sequence of Administration
    • Bible, K. C.; Kaufmann, S. H. Cytotoxic Synergy Between Flavopiridol (NSC 649890, L86-8275) and Various Antineoplastic Agents: the Importance of Sequence of Administration. Cancer Res. 1997, 57(16), 3375-3380.
    • (1997) Cancer Res , vol.57 , Issue.16 , pp. 3375-3380
    • Bible, K.C.1    Kaufmann, S.H.2
  • 57
    • 0034597571 scopus 로고    scopus 로고
    • Kim, K. S.; Sack, J. S.; Tokarski, J. S.; Qian, L.; Chao, S. T.; Leith, L.; Kelly, Y. F.; Misra, R. N.; Hunt, J. T.; Kimball, S. D.; Humphreys, W. G.; Wautlet, B. S.; Mulheron, J. G.; Webster, K. R. Thio- and Oxoflavopiridols, Cyclin-Dependent Kinase 1-Selective Inhibitors: Synthesis and Biological Effect. J. Med. Chem. 2000, 43(22), 4126-4134.
    • Kim, K. S.; Sack, J. S.; Tokarski, J. S.; Qian, L.; Chao, S. T.; Leith, L.; Kelly, Y. F.; Misra, R. N.; Hunt, J. T.; Kimball, S. D.; Humphreys, W. G.; Wautlet, B. S.; Mulheron, J. G.; Webster, K. R. Thio- and Oxoflavopiridols, Cyclin-Dependent Kinase 1-Selective Inhibitors: Synthesis and Biological Effect. J. Med. Chem. 2000, 43(22), 4126-4134.
  • 59
    • 31544431716 scopus 로고    scopus 로고
    • Fisetin Inhibits the Activities of Cyclin-Dependent Kinases Leading to Cell Cycle Arrest in HT-29 Human Colon Cancer Cells
    • Lu, X.; Jung, J.; Cho, H. J.; Lim, D. Y.; Lee, H. S.; Chun, H. S.; Kwon, D. Y.; Park, J. H. Fisetin Inhibits the Activities of Cyclin-Dependent Kinases Leading to Cell Cycle Arrest in HT-29 Human Colon Cancer Cells. J. Nutr. 2005, 135(12), 2884-2890.
    • (2005) J. Nutr , vol.135 , Issue.12 , pp. 2884-2890
    • Lu, X.1    Jung, J.2    Cho, H.J.3    Lim, D.Y.4    Lee, H.S.5    Chun, H.S.6    Kwon, D.Y.7    Park, J.H.8
  • 60
    • 13444311605 scopus 로고    scopus 로고
    • Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin
    • Lu, H.; Chang, D. J.; Baratte, B.; Meijer, L.; Schulze-Gahmen, S. Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin. J. Med. Chem. 2005, 48(3), 737-743.
    • (2005) J. Med. Chem , vol.48 , Issue.3 , pp. 737-743
    • Lu, H.1    Chang, D.J.2    Baratte, B.3    Meijer, L.4    Schulze-Gahmen, S.5
  • 61
    • 33846983918 scopus 로고    scopus 로고
    • 3-Hydroxychromones as Cyclin-Dependent Kinase Inhibitors: Synthesis and Biological Evaluation
    • Lee, A. J.; Park, T.; Jeong, S.; Kim, K. H.; Hong, C. 3-Hydroxychromones as Cyclin-Dependent Kinase Inhibitors: Synthesis and Biological Evaluation. Bioorg. Med. Chem. Lett. 2007, 17(5), 1284-1287.
    • (2007) Bioorg. Med. Chem. Lett , vol.17 , Issue.5 , pp. 1284-1287
    • Lee, A.J.1    Park, T.2    Jeong, S.3    Kim, K.H.4    Hong, C.5
  • 69
    • 20444477948 scopus 로고    scopus 로고
    • Seliciclib (CYC202, R-Roscovitine) Induces Cell Death in Multiple Myeloma Cells by Inhibition of RNA Polymerase II-Dependent Transcription and Down-Regulation of Mcl-1
    • MacCallum, D. E.; Melville, J.; Frame, S.; Watt, K.; Anderson, S.; Gianella-Borradori, A.; Lane, D. P.; Green, S. R. Seliciclib (CYC202, R-Roscovitine) Induces Cell Death in Multiple Myeloma Cells by Inhibition of RNA Polymerase II-Dependent Transcription and Down-Regulation of Mcl-1. Cancer Res. 2005, 65(12), 5399-5407.
    • (2005) Cancer Res , vol.65 , Issue.12 , pp. 5399-5407
    • MacCallum, D.E.1    Melville, J.2    Frame, S.3    Watt, K.4    Anderson, S.5    Gianella-Borradori, A.6    Lane, D.P.7    Green, S.R.8
  • 70
    • 33847679550 scopus 로고    scopus 로고
    • Seliciclib (CYC202; RRoscovitine) in Combination with Cytotoxic Agents in Human Uterine Sarcoma Cell Lines
    • Coley, H. M.; Shotton, C. F.; Thomas, H. Seliciclib (CYC202; RRoscovitine) in Combination with Cytotoxic Agents in Human Uterine Sarcoma Cell Lines. Anticancer Res. 2007, 27(1A), 273-278.
    • (2007) Anticancer Res , vol.27 , Issue.1 A , pp. 273-278
    • Coley, H.M.1    Shotton, C.F.2    Thomas, H.3
  • 71
    • 0037665145 scopus 로고    scopus 로고
    • Meijer, L.; Raymond, E. Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials. Acc. Chem. Res. 2003, 36(6), 417-425.
    • Meijer, L.; Raymond, E. Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials. Acc. Chem. Res. 2003, 36(6), 417-425.
  • 72
    • 0029090514 scopus 로고
    • Multiple Modes of Ligand Recognition: Crystal Structures of Cyclin-Dependent Protein Kinase 2 in Complex with ATP and Two Inhibitors, Olomoucine and Isopentenyladenine
    • Schulze-Gahmen, U.; Brandsen, J.; Jones, H. D.; Morgan, D. O.; Meijer, L.; Vesely, J.; Kim, S. H. Multiple Modes of Ligand Recognition: Crystal Structures of Cyclin-Dependent Protein Kinase 2 in Complex with ATP and Two Inhibitors, Olomoucine and Isopentenyladenine. Proteins 1995, 22(4), 378-391.
    • (1995) Proteins , vol.22 , Issue.4 , pp. 378-391
    • Schulze-Gahmen, U.1    Brandsen, J.2    Jones, H.D.3    Morgan, D.O.4    Meijer, L.5    Vesely, J.6    Kim, S.H.7
  • 73
    • 1842480065 scopus 로고    scopus 로고
    • Analysis of CDK2 Active-Site Hydration: A Method to Design New Inhibitors
    • Kriz, Z.; Otyepka, M.; Bartova, I.; Koca, J. Analysis of CDK2 Active-Site Hydration: a Method to Design New Inhibitors. Proteins 2004, 55(2), 258-274.
    • (2004) Proteins , vol.55 , Issue.2 , pp. 258-274
    • Kriz, Z.1    Otyepka, M.2    Bartova, I.3    Koca, J.4
  • 74
    • 0034011090 scopus 로고    scopus 로고
    • Activation of Bovine Oocytes by Specific Inhibition of Cyclin-Dependent Kinases
    • Alberio, R.; Kubelka, M.; Zakhartchenko, V.; Hajduch, M.; Wolf, E.; Motlik, J. Activation of Bovine Oocytes by Specific Inhibition of Cyclin-Dependent Kinases. Mol. Reprod. Dev. 2000, 55(4), 422-432.
    • (2000) Mol. Reprod. Dev , vol.55 , Issue.4 , pp. 422-432
    • Alberio, R.1    Kubelka, M.2    Zakhartchenko, V.3    Hajduch, M.4    Wolf, E.5    Motlik, J.6
  • 75
    • 7044260529 scopus 로고    scopus 로고
    • Meiotic Inhibition with Different Cyclin-Dependent Kinase Inhibitors in Bovine Oocytes and its Effects on Maturation and Embryo Development
    • Adona, P. R.; Lima Verde Leal, C. Meiotic Inhibition with Different Cyclin-Dependent Kinase Inhibitors in Bovine Oocytes and its Effects on Maturation and Embryo Development. Zygote 2004, 12(3), 197-204.
    • (2004) Zygote , vol.12 , Issue.3 , pp. 197-204
    • Adona, P.R.1    Lima Verde Leal, C.2
  • 76
    • 4444334494 scopus 로고    scopus 로고
    • Cassette Dosing Pharmacokinetics of a Library of 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase 2 Inhibitors Prepared by Parallel Synthesis
    • Raynaud, F. I.; Fischer, P. M.; Nutley, B. P.; Goddard, P. M.; Lane, D. P.; Workman, P. Cassette Dosing Pharmacokinetics of a Library of 2,6,9-Trisubstituted Purine Cyclin-Dependent Kinase 2 Inhibitors Prepared by Parallel Synthesis. Mol. Cancer Ther. 2004, 3(3), 353-362.
    • (2004) Mol. Cancer Ther , vol.3 , Issue.3 , pp. 353-362
    • Raynaud, F.I.1    Fischer, P.M.2    Nutley, B.P.3    Goddard, P.M.4    Lane, D.P.5    Workman, P.6
  • 79
    • 0032492705 scopus 로고    scopus 로고
    • Synthesis of C2 Alkynylated Purines, a New Family of Potent Inhibitors of Cyclin-Dependent Kinases
    • Legraverend, M.; Ludwig, O.; Bisagni, E.; LeClerc, S.; Meijer, L. Synthesis of C2 Alkynylated Purines, a New Family of Potent Inhibitors of Cyclin-Dependent Kinases. Bioorg. Med. Chem. Lett. 1998, 8(7), 793-798.
    • (1998) Bioorg. Med. Chem. Lett , vol.8 , Issue.7 , pp. 793-798
    • Legraverend, M.1    Ludwig, O.2    Bisagni, E.3    LeClerc, S.4    Meijer, L.5
  • 83
    • 39049167909 scopus 로고    scopus 로고
    • R.; Peet,
    • N. P, Munson, H. R, Shum Patrick, W. K. 9-Disubstituted-2-[trans-4-aminocyclohexyl, aminopurines, WO 99/43676, September 2, 1999
    • Dumont, J. A.; Bitonti, A. J.; Borcherding, D. R.; Peet, N. P.; Munson, H. R.; Shum Patrick, W. K. 9-Disubstituted-2-[trans-(4-aminocyclohexyl)] aminopurines, WO 99/43676, September 2, 1999.
    • Dumont, J.A.1    Bitonti, A.J.2    Borcherding, D.3
  • 84
    • 39049158052 scopus 로고    scopus 로고
    • Substituted Purine Derivatives as Potent Antiproliferative Agents
    • WO 03/022805 A2, March 20, 2003
    • Trova, M. P. Heterocycle Substituted Purine Derivatives as Potent Antiproliferative Agents. WO 03/022805 A2, March 20, 2003.
    • Trova, M.1    Heterocycle, P.2
  • 87
    • 0037242334 scopus 로고    scopus 로고
    • X-ray Crystallographic Studies of CDK2, a Basis for Cyclin-Dependent Kinase Inhibitor Design in Anti-Cancer Drug Research
    • Furet, P. X-ray Crystallographic Studies of CDK2, a Basis for Cyclin-Dependent Kinase Inhibitor Design in Anti-Cancer Drug Research. Curr. Med. Chem. Anti Cancer Agents 2003, 3(1), 15-23.
    • (2003) Curr. Med. Chem. Anti Cancer Agents , vol.3 , Issue.1 , pp. 15-23
    • Furet, P.1
  • 88
    • 0036710767 scopus 로고    scopus 로고
    • Pharmacological Inhibitors of Cyclin-Dependent Kinases
    • Knockaert, M.; Greengard, P.; Meijer, L. Pharmacological Inhibitors of Cyclin-Dependent Kinases. Trends Pharmacol. Sci. 2002, 23(9), 417-425.
    • (2002) Trends Pharmacol. Sci , vol.23 , Issue.9 , pp. 417-425
    • Knockaert, M.1    Greengard, P.2    Meijer, L.3
  • 89
    • 0032918488 scopus 로고    scopus 로고
    • 2,6,9-Trisubstituted Purines: Optimization Towards Highly Potent and Selective CDK1 Inhibitors
    • Imbach, P.; Capraro, H. G.; Furet, P.; Mett, H.; Meyer, T.; Zimmermann, J. 2,6,9-Trisubstituted Purines: Optimization Towards Highly Potent and Selective CDK1 Inhibitors. Bioorg. Med. Chem. Lett. 1999, 9(1), 91-96.
    • (1999) Bioorg. Med. Chem. Lett , vol.9 , Issue.1 , pp. 91-96
    • Imbach, P.1    Capraro, H.G.2    Furet, P.3    Mett, H.4    Meyer, T.5    Zimmermann, J.6
  • 91
    • 30544449645 scopus 로고    scopus 로고
    • Zinc(II) Complexes with Potent Cyclin-Dependent Kinase Inhibitors Derived from 6-Benzylaminopurine: Synthesis, Characterization, X-ray Structures and Biological Activity
    • Travnicek, Z.; Krystof, V.; Sipl, M. Zinc(II) Complexes with Potent Cyclin-Dependent Kinase Inhibitors Derived from 6-Benzylaminopurine: Synthesis, Characterization, X-ray Structures and Biological Activity. J. Inorg. Biochem. 2006, 100(2), 214-225.
    • (2006) J. Inorg. Biochem , vol.100 , Issue.2 , pp. 214-225
    • Travnicek, Z.1    Krystof, V.2    Sipl, M.3
  • 92
    • 0035818942 scopus 로고    scopus 로고
    • Bramson, H. N.; Corona, J.; Davis, S. T.; Dickerson, S. H.; Edelstein, M.; Frye, S. V.; Gampe, R. T. Jr.; Harris, P. A.; Hassell, A.; Holmes, W. D.; Hunter, R. N.; Lackey, K. E.; Lovejoy, B.; Luzzio, M. J.; Montana, V.; Rocque, W. J.; Rusnak, D.; Shewchuk, L.; Veal, J. M.; Walker, D. H.; Kuyper, L. F. Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2): Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis. J. Med. Chem. 2001, 44(25), 4339-4358.
    • Bramson, H. N.; Corona, J.; Davis, S. T.; Dickerson, S. H.; Edelstein, M.; Frye, S. V.; Gampe, R. T. Jr.; Harris, P. A.; Hassell, A.; Holmes, W. D.; Hunter, R. N.; Lackey, K. E.; Lovejoy, B.; Luzzio, M. J.; Montana, V.; Rocque, W. J.; Rusnak, D.; Shewchuk, L.; Veal, J. M.; Walker, D. H.; Kuyper, L. F. Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2): Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis. J. Med. Chem. 2001, 44(25), 4339-4358.
  • 93
    • 33846117613 scopus 로고    scopus 로고
    • 3D-QSAR CoMFA Study on Oxindole Derivatives as Cyclin Dependent Kinase 1 (CDK1) and Cyclin Dependent Kinase 2 (CDK2) Inhibitors
    • Singh, S. K.; Dessalew, N.; Bharatam, P. V. 3D-QSAR CoMFA Study on Oxindole Derivatives as Cyclin Dependent Kinase 1 (CDK1) and Cyclin Dependent Kinase 2 (CDK2) Inhibitors. Med. Chem. 2007, 3(1), 75-84.
    • (2007) Med. Chem , vol.3 , Issue.1 , pp. 75-84
    • Singh, S.K.1    Dessalew, N.2    Bharatam, P.V.3
  • 95
    • 33746238104 scopus 로고    scopus 로고
    • The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 Through a Transcriptional Mechanism
    • Gao, N.; Kramer, L.; Rahmani, M.; Dent, P.; Grant, S. The Three-Substituted Indolinone Cyclin-Dependent Kinase 2 Inhibitor 3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one (SU9516) Kills Human Leukemia Cells via Down-Regulation of Mcl-1 Through a Transcriptional Mechanism. Mol. Pharmacol. 2006, 70(2), 645-655.
    • (2006) Mol. Pharmacol , vol.70 , Issue.2 , pp. 645-655
    • Gao, N.1    Kramer, L.2    Rahmani, M.3    Dent, P.4    Grant, S.5
  • 96
    • 2542635063 scopus 로고    scopus 로고
    • Generation of New Protein Kinase Inhibitors Utilizing Cytochrome P450 Mutant Enzyme for Indigoid Synthesis
    • Guengerich, F. P.; Sorrells, J. L.; Schmitt, S.; Krauser, J. A.; Aryal, P.; Meijer, L. Generation of New Protein Kinase Inhibitors Utilizing Cytochrome P450 Mutant Enzyme for Indigoid Synthesis. J. Med. Chem. 2004, 47(12), 3236-3241.
    • (2004) J. Med. Chem , vol.47 , Issue.12 , pp. 3236-3241
    • Guengerich, F.P.1    Sorrells, J.L.2    Schmitt, S.3    Krauser, J.A.4    Aryal, P.5    Meijer, L.6
  • 100
    • 39049123508 scopus 로고    scopus 로고
    • Dependent Kinase Binding Compound
    • WO 97/11174, March 27
    • Lane, D. P. Cyclin Dependent Kinase Binding Compound. WO 97/11174, March 27, 1997.
    • (1997)
    • Lane, D.1    Cyclin, P.2
  • 101
    • 0032080613 scopus 로고    scopus 로고
    • Design of New Inhibitors for Cdc2 Kinase Based on Multiple Pseudosubstrate Structure
    • Sasaki, S.; Hashimuto, T.; Obana, N.; Yasuda, H.; Uehara, Y.; Maeda, M. Design of New Inhibitors for Cdc2 Kinase Based on Multiple Pseudosubstrate Structure. Bioorg. Med. Chem. Lett. 1998, 8(9), 1019-1022.
    • (1998) Bioorg. Med. Chem. Lett , vol.8 , Issue.9 , pp. 1019-1022
    • Sasaki, S.1    Hashimuto, T.2    Obana, N.3    Yasuda, H.4    Uehara, Y.5    Maeda, M.6
  • 102
    • 0037463754 scopus 로고    scopus 로고
    • Misra, R. N.; Rawlins, D. B.; Xiao, H. -Y.; Shan, W.; Bursuker, I.; Kellar, K. A.; Mulheron,y, J. G.; Sack, J. S.; Tokarski, J. S.; Kimball,y, D. S.; Webster, K. R. 1H-Pyrazolo[3,4-b]pyridine Inhibitors of Cyclin-Dependent Kinases. Bioorg. Med. Chem. Lett. 2003, 13(6), 1133-1136.
    • Misra, R. N.; Rawlins, D. B.; Xiao, H. -Y.; Shan, W.; Bursuker, I.; Kellar, K. A.; Mulheron,y, J. G.; Sack, J. S.; Tokarski, J. S.; Kimball,y, D. S.; Webster, K. R. 1H-Pyrazolo[3,4-b]pyridine Inhibitors of Cyclin-Dependent Kinases. Bioorg. Med. Chem. Lett. 2003, 13(6), 1133-1136.
  • 103
    • 20344402067 scopus 로고    scopus 로고
    • Insights from ab initio Quantum Chemical Calculations into the Preferred Tautomeric Forms and Binding Affinities to CDK2 of Substituted Pyrazolopyridines
    • Duca, J. S.; Madison, V. S. Insights from ab initio Quantum Chemical Calculations into the Preferred Tautomeric Forms and Binding Affinities to CDK2 of Substituted Pyrazolopyridines. Biopolymers 2005, 80(2-3), 312-318.
    • (2005) Biopolymers , vol.80 , Issue.2-3 , pp. 312-318
    • Duca, J.S.1    Madison, V.S.2
  • 104
    • 12444260278 scopus 로고    scopus 로고
    • Misra, R. N.; Rawlins, D. B.; Xiao, H.-Y.; Shan, W.; Bursuker, I.; Kellar, K. A.; Mulheron,y, J. G.; Sack, J. S.; Tokarski, J. S.; Kimball,y, D. S.; Webster, K. R. 1H-Pyrazolo[3,4-b]pyridine Inhibitors of Cyclin-Dependent Kinases: Highly Potent 2,6-Difluorophenacyl Analogues. Bioorg. Med. Chem. Lett. 2003, 13(14), 2405-2408.
    • Misra, R. N.; Rawlins, D. B.; Xiao, H.-Y.; Shan, W.; Bursuker, I.; Kellar, K. A.; Mulheron,y, J. G.; Sack, J. S.; Tokarski, J. S.; Kimball,y, D. S.; Webster, K. R. 1H-Pyrazolo[3,4-b]pyridine Inhibitors of Cyclin-Dependent Kinases: Highly Potent 2,6-Difluorophenacyl Analogues. Bioorg. Med. Chem. Lett. 2003, 13(14), 2405-2408.
  • 105
    • 33846914936 scopus 로고    scopus 로고
    • Synthesis of 3-(1H-Benzimidazol-2-yl)-5- isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a Potent CDK1 Inhibitor
    • Huang, S.; Lin, R.; Yu, Y.; Lu, Y.; Connolly, P. J.; Chiu, G.; Li, S.; Emanuel, S. L.; Middleton, S. A. Synthesis of 3-(1H-Benzimidazol-2-yl)-5- isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a Potent CDK1 Inhibitor. Bioorg. Med. Chem. Lett. 2007, 17(5), 1243-1245.
    • (2007) Bioorg. Med. Chem. Lett , vol.17 , Issue.5 , pp. 1243-1245
    • Huang, S.1    Lin, R.2    Yu, Y.3    Lu, Y.4    Connolly, P.J.5    Chiu, G.6    Li, S.7    Emanuel, S.L.8    Middleton, S.A.9
  • 106
    • 33645471100 scopus 로고    scopus 로고
    • The Cellular Phenotype of AZ703, a Novel Selective Imidazo[1,2-a]pyridine Cyclin-Dependent Kinase Inhibitor
    • Byths, K. F.; Geh, C.; Forder, C. L.; Oakes, S. E.; Thomas, A. P. The Cellular Phenotype of AZ703, a Novel Selective Imidazo[1,2-a]pyridine Cyclin-Dependent Kinase Inhibitor. Mol. Cancer Ther. 2006, 5(3), 655-664.
    • (2006) Mol. Cancer Ther , vol.5 , Issue.3 , pp. 655-664
    • Byths, K.F.1    Geh, C.2    Forder, C.L.3    Oakes, S.E.4    Thomas, A.P.5
  • 107
    • 31544459273 scopus 로고    scopus 로고
    • AZ703, an Imidazo[1,2-a]pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9
    • Cai, D.; Byth, K. F.; Shapiro, G. I. AZ703, an Imidazo[1,2-a]pyridine Inhibitor of Cyclin-Dependent Kinases 1 and 2, Induces E2F-1-Dependent Apoptosis Enhanced by Depletion of Cyclin-Dependent Kinase 9. Cancer Res. 2006, 66(1), 435-444.
    • (2006) Cancer Res , vol.66 , Issue.1 , pp. 435-444
    • Cai, D.1    Byth, K.F.2    Shapiro, G.I.3
  • 108
    • 39049159460 scopus 로고    scopus 로고
    • Dweyer, M. P.; Guzi, T. J.; Paruch, K.; Doll, R. J.; Keertikar, K. M.; Girijavallabham, V. M. Novel Pyrazolopyridines as Cyclin Dependent Kinase Inhibitors. WO 2004/026872 A1, April 1, 2004.
    • Dweyer, M. P.; Guzi, T. J.; Paruch, K.; Doll, R. J.; Keertikar, K. M.; Girijavallabham, V. M. Novel Pyrazolopyridines as Cyclin Dependent Kinase Inhibitors. WO 2004/026872 A1, April 1, 2004.
  • 109
    • 22244440750 scopus 로고    scopus 로고
    • Kuo, G. H.; Deangelis, A.; Emanuel, S.; Wang, A.; Zhang, Y.; Connolly, P. J.; Chen, X.; Gruninger, R. H.; Rugg, C.; Fuentes-Pesquera, A.; Middleton, S. A.; Jolliffe, L.; Murray, W. V. Synthesis and Identification of [1,3,5]Triazine-Pyridine Biheteroaryl as a Novel Series of Potent Cyclin-Dependent Kinase Inhibitors. J. Med. Chem. 2005, 48(14), 4535-4546.
    • Kuo, G. H.; Deangelis, A.; Emanuel, S.; Wang, A.; Zhang, Y.; Connolly, P. J.; Chen, X.; Gruninger, R. H.; Rugg, C.; Fuentes-Pesquera, A.; Middleton, S. A.; Jolliffe, L.; Murray, W. V. Synthesis and Identification of [1,3,5]Triazine-Pyridine Biheteroaryl as a Novel Series of Potent Cyclin-Dependent Kinase Inhibitors. J. Med. Chem. 2005, 48(14), 4535-4546.
  • 110
    • 33646846106 scopus 로고    scopus 로고
    • New Potential Inhibitors of Cyclin-Dependent Kinase 4: Design and Synthesis of Pyrido[2,3-d]pyrimidine Derivatives Under Microwave Irradition
    • Tu, S.; Zhang, J.; Zhu, X.; Xu, J.; Zang, Y.; Wang, Q.; Jia, R.; Jiang, B.; Zhang, J. New Potential Inhibitors of Cyclin-Dependent Kinase 4: Design and Synthesis of Pyrido[2,3-d]pyrimidine Derivatives Under Microwave Irradition. Bioorg. Med. Chem. Lett. 2006, 16(13), 3578-3581.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , Issue.13 , pp. 3578-3581
    • Tu, S.1    Zhang, J.2    Zhu, X.3    Xu, J.4    Zang, Y.5    Wang, Q.6    Jia, R.7    Jiang, B.8    Zhang, J.9
  • 111
    • 0034736093 scopus 로고    scopus 로고
    • Barvian, M.; Boschelli, D. H.; Cossrow, J.; Dobrusin, E.; Fattaey, A.; Fritsch, A.; Fry, D.; Harvey, P.; Keller, P.; Garrett, M.; La, F.; Leopold, W.; McNamara, D.; Quin, M.; Trumpp-Kallmeyer, S.; Toogood, P.; Wu, Z.; Zhang, E. Pyrido-[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases. J. Med. Chem. 2000, 43, 4606-4616.
    • Barvian, M.; Boschelli, D. H.; Cossrow, J.; Dobrusin, E.; Fattaey, A.; Fritsch, A.; Fry, D.; Harvey, P.; Keller, P.; Garrett, M.; La, F.; Leopold, W.; McNamara, D.; Quin, M.; Trumpp-Kallmeyer, S.; Toogood, P.; Wu, Z.; Zhang, E. Pyrido-[2,3-d]pyrimidin-7-one Inhibitors of Cyclin-Dependent Kinases. J. Med. Chem. 2000, 43, 4606-4616.
  • 114
    • 8744236193 scopus 로고    scopus 로고
    • Markwalder, J. A.; Arnone, M. R.; Benfield, P. A.; Boisclair, M.; Burton, C. R.; Chang, C. H.; Cox, S. S.; Czerniak, P. M.; Dean, C. L.; Doleniak, D.; Grafstrom, R.; Harrison, B. A.; Kaltenbach, R. F. III.; Nugiel, D.; Rosi, K. A.; Sherk, S. R.; Sisk, L. M.; Stouten, P.; Trainor, G. L.; Worland, P.; Seitz, S. P. Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[ 3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases. J. Med. Chem. 2004, 47(24), 5894-5911.
    • Markwalder, J. A.; Arnone, M. R.; Benfield, P. A.; Boisclair, M.; Burton, C. R.; Chang, C. H.; Cox, S. S.; Czerniak, P. M.; Dean, C. L.; Doleniak, D.; Grafstrom, R.; Harrison, B. A.; Kaltenbach, R. F. III.; Nugiel, D.; Rosi, K. A.; Sherk, S. R.; Sisk, L. M.; Stouten, P.; Trainor, G. L.; Worland, P.; Seitz, S. P. Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[ 3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases. J. Med. Chem. 2004, 47(24), 5894-5911.
  • 115
    • 39049090277 scopus 로고    scopus 로고
    • Markwalder, J. A, Seitz, S. P, Sherk, S. R. 6-Substituted Pyrazolo(3,4-d)pyrimidin-4-ones Useful as Cyclin Dependent Kinase Inhibitors. WO 00/21926, April 20, 2000
    • Markwalder, J. A.; Seitz, S. P.; Sherk, S. R. 6-Substituted Pyrazolo(3,4-d)pyrimidin-4-ones Useful as Cyclin Dependent Kinase Inhibitors. WO 00/21926, April 20, 2000.
  • 117
    • 39049154122 scopus 로고    scopus 로고
    • Pyrimidine Compounds
    • WO 03/076433, September 18
    • Newcombe, N. J.; Thomas, A. P. Pyrimidine Compounds. WO 03/076433, September 18, 2003.
    • (2003)
    • Newcombe, N.J.1    Thomas, A.P.2
  • 120
    • 33746805407 scopus 로고    scopus 로고
    • Synthesis of 2-Amino-4-(7-azaindol-3-yl)pyrimidines as Cyclin Dependent Kinase 1 (CDK1) Inhibitors
    • Huang, S.; Li, R.; Connolly, P. J.; Emanuel, S.; Middleton, S. A. Synthesis of 2-Amino-4-(7-azaindol-3-yl)pyrimidines as Cyclin Dependent Kinase 1 (CDK1) Inhibitors. Bioorg. Med. Chem. Lett. 2006, 16(18), 4818-4821.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , Issue.18 , pp. 4818-4821
    • Huang, S.1    Li, R.2    Connolly, P.J.3    Emanuel, S.4    Middleton, S.A.5
  • 123
    • 39049104616 scopus 로고    scopus 로고
    • Pyrimidine Compounds
    • WO 01/64653 A1, September 7, 2001
    • Pease, E. J.; Breault, G. A.; Bradbury, R. H. Pyrimidine Compounds. WO 01/64653 A1, September 7, 2001.
    • Pease, E.J.1    Breault, G.A.2    Bradbury, R.H.3
  • 125
    • 39049122917 scopus 로고    scopus 로고
    • Pease, E. J, Breault, G. A, Williams, E. J, Bradbury, R. H, Morris, J. J. 2,4-Di (hetero-)arylamino(-oxy)-5-substutited Pyrimidines as Antineoplastic Agents. WO 01/64655 A1, September 7, 2001
    • Pease, E. J.; Breault, G. A.; Williams, E. J.; Bradbury, R. H.; Morris, J. J. 2,4-Di (hetero-)arylamino(-oxy)-5-substutited Pyrimidines as Antineoplastic Agents. WO 01/64655 A1, September 7, 2001.
  • 127
    • 39049145011 scopus 로고    scopus 로고
    • Newcombe, N. J.; Thomas, A. P. 2-Anilino-Pyrimidine Derivatives as Cyclin Depenedent Kinase Inhibitors. WO 02/096887, December 5, 2002.
    • Newcombe, N. J.; Thomas, A. P. 2-Anilino-Pyrimidine Derivatives as Cyclin Depenedent Kinase Inhibitors. WO 02/096887, December 5, 2002.
  • 128
    • 33750429279 scopus 로고    scopus 로고
    • Chu, X. J.; DePinto, W.; Bartkovitz, D.; So, S. S.; Vu, B. T.; Packman, K.; Lukacs, C.; Ding, Q.; Jiang, N.; Wang, K.; Goelzer, P.; Yin, X.; Smith, M. A.; Higgins, B. X.; Chen, Y.; Xiang, Q.; Moliterni, J.; Kaplan, G.; Graves, B.; Lovey, A.; Fotouhi, N. Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4- ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone (R547), a Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in vivo Antitumor Activity. J. Med. Chem. 2006, 49(22), 6549-6560.
    • Chu, X. J.; DePinto, W.; Bartkovitz, D.; So, S. S.; Vu, B. T.; Packman, K.; Lukacs, C.; Ding, Q.; Jiang, N.; Wang, K.; Goelzer, P.; Yin, X.; Smith, M. A.; Higgins, B. X.; Chen, Y.; Xiang, Q.; Moliterni, J.; Kaplan, G.; Graves, B.; Lovey, A.; Fotouhi, N. Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4- ylamino)pyrimidin-5-yl](2,3-difluoro-6-methoxyphenyl)methanone (R547), a Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in vivo Antitumor Activity. J. Med. Chem. 2006, 49(22), 6549-6560.
  • 130
    • 0036332286 scopus 로고    scopus 로고
    • Indirubin and Meisoindigo in the Treatment of Chronic Myelogenous Leukemia in China
    • Xiao, Z.; Hao, Y.; Liu, B.; Qian, L. Indirubin and Meisoindigo in the Treatment of Chronic Myelogenous Leukemia in China. Leuk. Lymphoma 2002, 43(9), 1763-1768.
    • (2002) Leuk. Lymphoma , vol.43 , Issue.9 , pp. 1763-1768
    • Xiao, Z.1    Hao, Y.2    Liu, B.3    Qian, L.4
  • 132
    • 0035147448 scopus 로고    scopus 로고
    • Inhibition of Cyclin-Dependent Kinase 1 (CDK1) by Indirubin Derivatives in Human Tumour Cells
    • Marko, D.; Schatzle, S.; Friedel, A.; Genzlinger, A.; Zankl, H.; Meijer, L.; Eisenbrand, G. Inhibition of Cyclin-Dependent Kinase 1 (CDK1) by Indirubin Derivatives in Human Tumour Cells. Br. J. Cancer 2001, 84(2), 283-289.
    • (2001) Br. J. Cancer , vol.84 , Issue.2 , pp. 283-289
    • Marko, D.1    Schatzle, S.2    Friedel, A.3    Genzlinger, A.4    Zankl, H.5    Meijer, L.6    Eisenbrand, G.7
  • 133
    • 2942544255 scopus 로고    scopus 로고
    • Binding of the Potential Antitumour Agent Indirubin-5-sulphonate at the Inhibitor Site of Rabbit Muscle Glycogen Phosphorylase b. Comparison with Ligand Binding to pCDK2/cyclin A Complex
    • Kosmopoulou, M. N.; Leonidas, D. D.; Chrysina, E. D.; Bischler, N.; Eisenbrand, G.; Sakarellos, C. E.; Pauptit, R.; Oikonomakos, N. G. Binding of the Potential Antitumour Agent Indirubin-5-sulphonate at the Inhibitor Site of Rabbit Muscle Glycogen Phosphorylase b. Comparison with Ligand Binding to pCDK2/cyclin A Complex. Eur. J. Biochem. 2004, 271(11), 2280-2290.
    • (2004) Eur. J. Biochem , vol.271 , Issue.11 , pp. 2280-2290
    • Kosmopoulou, M.N.1    Leonidas, D.D.2    Chrysina, E.D.3    Bischler, N.4    Eisenbrand, G.5    Sakarellos, C.E.6    Pauptit, R.7    Oikonomakos, N.G.8
  • 134
    • 0035963318 scopus 로고    scopus 로고
    • Anti-Mitotic Properties of Indirubin-3′-monoxime, a CDK/GSK-3 Inhibitor: Induction of Endoreplication Following Prophase Arrest
    • Damiens, E.; Baratte, B.; Marie, D.; Eisenbrand, G.; Meijer, L. Anti-Mitotic Properties of Indirubin-3′-monoxime, a CDK/GSK-3 Inhibitor: Induction of Endoreplication Following Prophase Arrest. Oncogene 2001, 20(29), 3786-3797.
    • (2001) Oncogene , vol.20 , Issue.29 , pp. 3786-3797
    • Damiens, E.1    Baratte, B.2    Marie, D.3    Eisenbrand, G.4    Meijer, L.5
  • 135
    • 33745594039 scopus 로고    scopus 로고
    • Indirubin-3′-monoxime, a CDK Inhibitor Induces Growth Inhibition and Apoptosis-Independent Up-regulation of Survivin in Transitional Cell Cancer
    • Perabo, F. G.; Frossler, C.; Landwehrs, G.; Schmidt, D. H.; von Rucker, A.; Wirger, A.; Muller, S. C. Indirubin-3′-monoxime, a CDK Inhibitor Induces Growth Inhibition and Apoptosis-Independent Up-regulation of Survivin in Transitional Cell Cancer. Anticancer Res. 2006, 26(3A), 2129-2135.
    • (2006) Anticancer Res , vol.26 , Issue.3 A , pp. 2129-2135
    • Perabo, F.G.1    Frossler, C.2    Landwehrs, G.3    Schmidt, D.H.4    von Rucker, A.5    Wirger, A.6    Muller, S.C.7
  • 136
    • 34648853657 scopus 로고    scopus 로고
    • Study of the Inhibition of Cyclin-Dependent Kinases with Roscovitine and Indirubin-3′- oxime from Molecular Dynamics Simulations
    • Zhang, B.; Tan, V. B.; Lim, K. M.; Tay, T. E.; Zhuang, S. Study of the Inhibition of Cyclin-Dependent Kinases with Roscovitine and Indirubin-3′- oxime from Molecular Dynamics Simulations. J. Mol. Model. 2007, 13(1), 79-89.
    • (2007) J. Mol. Model , vol.13 , Issue.1 , pp. 79-89
    • Zhang, B.1    Tan, V.B.2    Lim, K.M.3    Tay, T.E.4    Zhuang, S.5
  • 140
    • 33749650162 scopus 로고    scopus 로고
    • Exploring QSAR on 3-Aminopyrazoles as Antitumor Agents for their Inhibitory Activity of CDK2/cyclin A
    • Samanta, S.; Debnath, B.; Basu, A.; Gayen, S.; Srikanth, K.; Jha, T. Exploring QSAR on 3-Aminopyrazoles as Antitumor Agents for their Inhibitory Activity of CDK2/cyclin A. Eur. J. Med. Chem. 2006, 41(10), 1190-1195.
    • (2006) Eur. J. Med. Chem , vol.41 , Issue.10 , pp. 1190-1195
    • Samanta, S.1    Debnath, B.2    Basu, A.3    Gayen, S.4    Srikanth, K.5    Jha, T.6
  • 141
    • 2942522534 scopus 로고    scopus 로고
    • Pevarello, P.; Brasca, M. G.; Amichi, R.; Orsini, P.; Traquandi, G.; Corti, L.; Piutti, C.; Sansonna, P.; Villa, M.; Pierce, B. S.; Pulici, M.; Giordano, P.; Martina, K.; Fritzen, E. L.; Nugent, R. A.; Casale, E.; Cameron, A.; Ciomei, M.; Roletto, F.; Isacchi, A.; Fogliatto, G. P.; Pesenti, F.; Pastori, W.; Marsiglio, A.; Leach, K. L.; Clare, P. M.; Fiorentini, F.; Varasi, M.; Vulpetti, A. 3-Aminopyrazole Inhibitors of CDK2/cyclin A as Antitumor Agents. 1. Lead Finding. J. Med. Chem. 2004, 47(13), 3367-3380.
    • Pevarello, P.; Brasca, M. G.; Amichi, R.; Orsini, P.; Traquandi, G.; Corti, L.; Piutti, C.; Sansonna, P.; Villa, M.; Pierce, B. S.; Pulici, M.; Giordano, P.; Martina, K.; Fritzen, E. L.; Nugent, R. A.; Casale, E.; Cameron, A.; Ciomei, M.; Roletto, F.; Isacchi, A.; Fogliatto, G. P.; Pesenti, F.; Pastori, W.; Marsiglio, A.; Leach, K. L.; Clare, P. M.; Fiorentini, F.; Varasi, M.; Vulpetti, A. 3-Aminopyrazole Inhibitors of CDK2/cyclin A as Antitumor Agents. 1. Lead Finding. J. Med. Chem. 2004, 47(13), 3367-3380.
  • 143
    • 33646480483 scopus 로고    scopus 로고
    • Nesi, M.; Borghi, D.; Brasca, M. G.; Fiorentini, F.; Pevarello, P. A Practical Synthesis of the Major 3-Hydroxy-2-pyrrolidinone Metabolite of a Potent CDK2/cyclin A Inhibitor. Bioorg. Med. Chem. Lett. 2006, 16(12), 3205-3208.
    • Nesi, M.; Borghi, D.; Brasca, M. G.; Fiorentini, F.; Pevarello, P. A Practical Synthesis of the Major 3-Hydroxy-2-pyrrolidinone Metabolite of a Potent CDK2/cyclin A Inhibitor. Bioorg. Med. Chem. Lett. 2006, 16(12), 3205-3208.
  • 145
    • 0037153230 scopus 로고    scopus 로고
    • Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 2. Probing the Indeno Ring Substituent Pattern
    • Nugiel, D. A.; Vidwans, A.; Etzkorn, A. M.; Rossi, K. A.; Benfield, P. A.; Burton, C. R.; Cox, S.; Doleniak, D.; Seitz, S. P. Synthesis and Evaluation of Indenopyrazoles as Cyclin-Dependent Kinase Inhibitors. 2. Probing the Indeno Ring Substituent Pattern. J. Med. Chem. 2002, 45(24), 5224-5232.
    • (2002) J. Med. Chem , vol.45 , Issue.24 , pp. 5224-5232
    • Nugiel, D.A.1    Vidwans, A.2    Etzkorn, A.M.3    Rossi, K.A.4    Benfield, P.A.5    Burton, C.R.6    Cox, S.7    Doleniak, D.8    Seitz, S.P.9
  • 146
    • 33751105911 scopus 로고    scopus 로고
    • 3D-QSAR CoMFA Study on Indenopyrazole Derivatives as Cyclin-Dependent Kinase 4 (CDK4) and Cyclin-Dependent Kinase 2 (CDK2) Inhibitors
    • Singh, S. K.; Dessalew, N.; Bharatam, P. V. 3D-QSAR CoMFA Study on Indenopyrazole Derivatives as Cyclin-Dependent Kinase 4 (CDK4) and Cyclin-Dependent Kinase 2 (CDK2) Inhibitors. Eur. J. Med. Chem. 2006, 41(11), 1310-1319.
    • (2006) Eur. J. Med. Chem , vol.41 , Issue.11 , pp. 1310-1319
    • Singh, S.K.1    Dessalew, N.2    Bharatam, P.V.3
  • 148
    • 0037194619 scopus 로고    scopus 로고
    • Kim, K.; Kimball, S. D.; Misra, R. N.; Rawlins, D. B.; Hunt, J. T.; Xiao, H. Y.; Lu, S.; Qian, L.; Han, W. C.; Shan, W.; Mitt, T.; Cai, Z. W.; Poss, M. A.; Zhu, H.; Sack, J. S.; Tokarski, J. S.; Chang, C. Y.; Pavletich, N.; Kamath, A.; Humphreys, W. G.; Marathe, P.; Bursuker, I.; Kellar, K. A.; Roongta, U.; Batorsky, R.; Mulheron, J. G.; Bol, D.; Fairchild, C. R.; Lee, F. Y.; Webster, K. R. Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-ray Crystallographic Analysis, and Biological Activities. J. Med. Chem. 2002, 45(18), 3905-3927.
    • Kim, K.; Kimball, S. D.; Misra, R. N.; Rawlins, D. B.; Hunt, J. T.; Xiao, H. Y.; Lu, S.; Qian, L.; Han, W. C.; Shan, W.; Mitt, T.; Cai, Z. W.; Poss, M. A.; Zhu, H.; Sack, J. S.; Tokarski, J. S.; Chang, C. Y.; Pavletich, N.; Kamath, A.; Humphreys, W. G.; Marathe, P.; Bursuker, I.; Kellar, K. A.; Roongta, U.; Batorsky, R.; Mulheron, J. G.; Bol, D.; Fairchild, C. R.; Lee, F. Y.; Webster, K. R. Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-ray Crystallographic Analysis, and Biological Activities. J. Med. Chem. 2002, 45(18), 3905-3927.
  • 149
    • 33846796243 scopus 로고    scopus 로고
    • 3D-QSAR CoFMA Study on Aminothiazole Derivatives as Cyclin-Dependent Kinase 2
    • Dessalew, N.; Bharatama, P. V.; Singh, S. K. 3D-QSAR CoFMA Study on Aminothiazole Derivatives as Cyclin-Dependent Kinase 2. QSAR & Combinatorial Science 2006, 26(1), 85-91.
    • (2006) QSAR & Combinatorial Science , vol.26 , Issue.1 , pp. 85-91
    • Dessalew, N.1    Bharatama, P.V.2    Singh, S.K.3
  • 150
    • 12144285797 scopus 로고    scopus 로고
    • Misra, R. N.; Xiao H. Y.; Kim, K. S.; Lu, S.; Han W. C.; Barbosa, S. A.; Hunt, J. T.; Rawlins, D. B.; Shan, W.; Ahmed, S. Z.; Qian, L.; Chen, B. C.; Zhao, R.; Bednarz, M. S.; Kellar, K. A.; Mulheron, J. G.; Batorsky, R.; Roongta, U.; Kamath, A.; Marathe, P.; Ranadive, S. A.; Sack, J. S.; Tokarski, J. S; Pavletich, N. P.; Lee, F. Y.; Webster, K. R.; Kimball, S. D. N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent. J. Med. Chem. 2004, 47(7), 1719-1728.
    • Misra, R. N.; Xiao H. Y.; Kim, K. S.; Lu, S.; Han W. C.; Barbosa, S. A.; Hunt, J. T.; Rawlins, D. B.; Shan, W.; Ahmed, S. Z.; Qian, L.; Chen, B. C.; Zhao, R.; Bednarz, M. S.; Kellar, K. A.; Mulheron, J. G.; Batorsky, R.; Roongta, U.; Kamath, A.; Marathe, P.; Ranadive, S. A.; Sack, J. S.; Tokarski, J. S; Pavletich, N. P.; Lee, F. Y.; Webster, K. R.; Kimball, S. D. N-(Cycloalkylamino)acyl-2-aminothiazole Inhibitors of Cyclin-Dependent Kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a Highly Efficacious and Selective Antitumor Agent. J. Med. Chem. 2004, 47(7), 1719-1728.
  • 151
    • 33644615052 scopus 로고    scopus 로고
    • Structure-Based Drug Design to the Discovery of New 2-Aminothiazole CDK2 Inhibitors
    • Vulpetti, A.; Casale, E.; Roletto, F.; Amici, R.; Villa , M.; Pevarello, P. Structure-Based Drug Design to the Discovery of New 2-Aminothiazole CDK2 Inhibitors. J. Mol. Graphics Modell. 2006, 24(5), 341-348.
    • (2006) J. Mol. Graphics Modell , vol.24 , Issue.5 , pp. 341-348
    • Vulpetti, A.1    Casale, E.2    Roletto, F.3    Amici, R.4    Villa, M.5    Pevarello, P.6
  • 152
    • 39049170525 scopus 로고    scopus 로고
    • Phenylacetamido-Thiazole Derivatives, Process for Their Preparation and Their Use as Antitumor Agents
    • WO 03/008365, January 30
    • Pevarello P.; Amici, R.; Villa, M.; Salom, B.; Vulptti, A.; Varasi, M.; Brasca, M. G.; Traquandi, G.; Nesi, M. Phenylacetamido-Thiazole Derivatives, Process for Their Preparation and Their Use as Antitumor Agents. WO 03/008365, January 30, 2003.
    • (2003)
    • Pevarello, P.1    Amici, R.2    Villa, M.3    Salom, B.4    Vulptti, A.5    Varasi, M.6    Brasca, M.G.7    Traquandi, G.8    Nesi, M.9
  • 154
    • 39049103650 scopus 로고    scopus 로고
    • Pyrazole-Thiazole Compounds, Pharmaceutical Compositions Containing them, and Methods of their Use for Inhibiting Cyclin-Dependent Kinases
    • WO 02/12250, February 14
    • Chong, W. K. M.; Duvadie, R. K. Pyrazole-Thiazole Compounds, Pharmaceutical Compositions Containing them, and Methods of their Use for Inhibiting Cyclin-Dependent Kinases. WO 02/12250, February 14, 2002.
    • (2002)
    • Chong, W.K.M.1    Duvadie, R.K.2
  • 156
    • 33746542555 scopus 로고    scopus 로고
    • Shimamura, T.; Shibata, J.; Kurihara, H.; Mita, T.; Otsuki, S.; Sagara, T.; Hirai, H.; Iwasawa, Y. Identification of Potent 5-Pyrimidinyl-2- aminothiazole CDK4, 6 Inhibitors with Significant Selectivity over CDK1, 2, 5, 7, and 9. Bioorg. Med. Chem. Lett. 2006, 16(14), 3751-3754.
    • Shimamura, T.; Shibata, J.; Kurihara, H.; Mita, T.; Otsuki, S.; Sagara, T.; Hirai, H.; Iwasawa, Y. Identification of Potent 5-Pyrimidinyl-2- aminothiazole CDK4, 6 Inhibitors with Significant Selectivity over CDK1, 2, 5, 7, and 9. Bioorg. Med. Chem. Lett. 2006, 16(14), 3751-3754.
  • 160
    • 0037387215 scopus 로고    scopus 로고
    • Lahusen, T.; De Siervi, A.; Kunick, C.; Senderowicz, A. M. Alsterpaullone, a Novel Cyclin-Dependent Kinase Inhibitor, Induces Apoptosis by Activation of Caspase-9 Due to Perturbation in Mitochondrial Membrane Potential. Mol. Carcinog. 2003, 36(4), 183-194.
    • Lahusen, T.; De Siervi, A.; Kunick, C.; Senderowicz, A. M. Alsterpaullone, a Novel Cyclin-Dependent Kinase Inhibitor, Induces Apoptosis by Activation of Caspase-9 Due to Perturbation in Mitochondrial Membrane Potential. Mol. Carcinog. 2003, 36(4), 183-194.
  • 162
    • 23944447173 scopus 로고    scopus 로고
    • New Thiophene Analogues of Kenpaullone: Synthesis and Biological Evaluation in Breast Cancer Cells
    • Brault, L.; Migianu, E.; Neguesque, A.; Battaglia, E.; Bagrel, D.; Kirsch, G. New Thiophene Analogues of Kenpaullone: Synthesis and Biological Evaluation in Breast Cancer Cells. Eur. J. Med. Chem. 2005, 40(8), 757-763.
    • (2005) Eur. J. Med. Chem , vol.40 , Issue.8 , pp. 757-763
    • Brault, L.1    Migianu, E.2    Neguesque, A.3    Battaglia, E.4    Bagrel, D.5    Kirsch, G.6
  • 163
    • 0347360271 scopus 로고    scopus 로고
    • 1-Azakenpaullone is a Selective Inhibitor of Glycogen Synthase Kinase-3β
    • Kunick, C.; Lauenroth, K.; Leost, M.; Meijer, L.; Lemcke, T. 1-Azakenpaullone is a Selective Inhibitor of Glycogen Synthase Kinase-3β. Bioorg. Med. Chem. Lett. 2004, 14(2), 413-416.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , Issue.2 , pp. 413-416
    • Kunick, C.1    Lauenroth, K.2    Leost, M.3    Meijer, L.4    Lemcke, T.5
  • 164
    • 0001006448 scopus 로고
    • Isolation and X-ray Crystal Structure of a Novel Bromo Compound from Two Marine Sponges
    • Cimino, G.; De Rosa, S.; De Stefano, S.; Mazzarella, L.; Puliti, R.; Sodano, G. Isolation and X-ray Crystal Structure of a Novel Bromo Compound from Two Marine Sponges. Tetrahedron Lett. 1982, 23(7), 767-768.
    • (1982) Tetrahedron Lett , vol.23 , Issue.7 , pp. 767-768
    • Cimino, G.1    De Rosa, S.2    De Stefano, S.3    Mazzarella, L.4    Puliti, R.5    Sodano, G.6
  • 169
    • 0027186226 scopus 로고    scopus 로고
    • Kitagawa, M.; Okabe, T.; Ogino, H.; Matsumoto, H.; Suzuki-Takahashi, I.; Kokubo, T.; Higashi, H.; Saitoh, S.; Taya, Y.; Yasuda, H. Butyrolactone I, a Selective Inhibitor of CDK2 and Cdc2 Kinase. Oncogene 1993, 8(9), 2425-2432.
    • Kitagawa, M.; Okabe, T.; Ogino, H.; Matsumoto, H.; Suzuki-Takahashi, I.; Kokubo, T.; Higashi, H.; Saitoh, S.; Taya, Y.; Yasuda, H. Butyrolactone I, a Selective Inhibitor of CDK2 and Cdc2 Kinase. Oncogene 1993, 8(9), 2425-2432.
  • 170
    • 3142694085 scopus 로고    scopus 로고
    • Synthesis and Biological Evaluation of Analogues of Butyrolactone I and Molecular Model of its Interaction with CDK2
    • Brana, M. F.; Garcia, M. L.; Lopez, B.; de Pascual-Teresa, B.; Ramos, A.; Pozuelo, J. M.; Dominguez, M. T. Synthesis and Biological Evaluation of Analogues of Butyrolactone I and Molecular Model of its Interaction with CDK2. Org. Biomol. Chem. 2004, 2(13), 1864-1871.
    • (2004) Org. Biomol. Chem , vol.2 , Issue.13 , pp. 1864-1871
    • Brana, M.F.1    Garcia, M.L.2    Lopez, B.3    de Pascual-Teresa, B.4    Ramos, A.5    Pozuelo, J.M.6    Dominguez, M.T.7
  • 172
    • 0034800665 scopus 로고    scopus 로고
    • Cyclin-Dependent Kinase Inhibitors for Treating Cancer
    • Toogood, P. L. Cyclin-Dependent Kinase Inhibitors for Treating Cancer. Med. Res. Rev. 2001, 6, 487-498.
    • (2001) Med. Res. Rev , vol.6 , pp. 487-498
    • Toogood, P.L.1
  • 173
    • 0029873937 scopus 로고    scopus 로고
    • Cui, C. -B.; Ubukata, M.; Kakeya, H.; Onuse, R.; Okada, I.; Takahashi, K.; Isono, K.; Osada, H. Acetophthalidin, a Novel Inhibitor of Mammalian Cell Cycle, Produced by a Fungus Isolated from a Sea Sediment. J. Antibiot. (Tokyo) 1996, 49(2), 216-219.
    • Cui, C. -B.; Ubukata, M.; Kakeya, H.; Onuse, R.; Okada, I.; Takahashi, K.; Isono, K.; Osada, H. Acetophthalidin, a Novel Inhibitor of Mammalian Cell Cycle, Produced by a Fungus Isolated from a Sea Sediment. J. Antibiot. (Tokyo) 1996, 49(2), 216-219.
  • 174
    • 33748836655 scopus 로고    scopus 로고
    • Synthetic Microbial Chemistry. Part 30. Synthesis of Acetophthalidin, a Fungal Metabolite which Inhibits the Progression of the Mammalian Cell Cycle
    • Nomoto, S.; Mori, K. Synthetic Microbial Chemistry. Part 30. Synthesis of Acetophthalidin, a Fungal Metabolite which Inhibits the Progression of the Mammalian Cell Cycle. Liebigs Ann. Recl. 1997, 4, 721-723.
    • (1997) Liebigs Ann. Recl , vol.4 , pp. 721-723
    • Nomoto, S.1    Mori, K.2
  • 177
    • 33747336252 scopus 로고    scopus 로고
    • Kawanishi, N.; Sugimoto, T.; Shibata, J.; Nakamura, K.; Masutani, K.; Ikuta, M.; Hirai, H. Structure-Based Drug Design of a Highly Potent CDK1,2,4,6 Inhibitor with Novel Macrocyclic Quinoxalin-2-one Structure. Bioorg. Med. Chem. Lett. 2006, 16(19), 5122-5126.
    • Kawanishi, N.; Sugimoto, T.; Shibata, J.; Nakamura, K.; Masutani, K.; Ikuta, M.; Hirai, H. Structure-Based Drug Design of a Highly Potent CDK1,2,4,6 Inhibitor with Novel Macrocyclic Quinoxalin-2-one Structure. Bioorg. Med. Chem. Lett. 2006, 16(19), 5122-5126.
  • 178
    • 27844579211 scopus 로고    scopus 로고
    • Molecular Chemoprevention by Selenium: A Genomic Approach
    • El-Bayoumy, K.; Sinha, R. Molecular Chemoprevention by Selenium: a Genomic Approach. Mutat. Res. 2005, 591(1-2), 224-236.
    • (2005) Mutat. Res , vol.591 , Issue.1-2 , pp. 224-236
    • El-Bayoumy, K.1    Sinha, R.2
  • 179
    • 0031418209 scopus 로고    scopus 로고
    • Inhibition of CDK2 Kinase Activity by Methylselenocysteine in Synchronized Mouse Mammary Epithelial Tumor Cells
    • Sinha, R.; Medina, D. Inhibition of CDK2 Kinase Activity by Methylselenocysteine in Synchronized Mouse Mammary Epithelial Tumor Cells. Carcinogenesis 1997, 18(8), 1541-1547.
    • (1997) Carcinogenesis , vol.18 , Issue.8 , pp. 1541-1547
    • Sinha, R.1    Medina, D.2
  • 180
    • 0036213746 scopus 로고    scopus 로고
    • Selenite and Selenomethionine Promote HL-60 Cell Cycle Progression
    • Zeng, H. Selenite and Selenomethionine Promote HL-60 Cell Cycle Progression. J. Nutr. 2002, 132(4), 674-679.
    • (2002) J. Nutr , vol.132 , Issue.4 , pp. 674-679
    • Zeng, H.1
  • 181
    • 33845301978 scopus 로고    scopus 로고
    • Chemopreventive Agents Alters Global Gene Expression Pattern: Predicting their Mode of Action and Targets
    • Narayanan, B. A. Chemopreventive Agents Alters Global Gene Expression Pattern: Predicting their Mode of Action and Targets. Current Cancer Drug Targets 2006, 6(8), 711-727.
    • (2006) Current Cancer Drug Targets , vol.6 , Issue.8 , pp. 711-727
    • Narayanan, B.A.1
  • 182
    • 33748579945 scopus 로고    scopus 로고
    • Inhibition of Cancer Cell Growth by Cyclin Dependent Kinase 4 Inhibitors Synthesized Based on the Structure of Fascaplysin
    • Mahale, S.; Aubry, C.; Jenkins, P. R.; Marechal, J. D.; Sutcliffe, M. J.; Chaudhuri, B. Inhibition of Cancer Cell Growth by Cyclin Dependent Kinase 4 Inhibitors Synthesized Based on the Structure of Fascaplysin. Bioorg. Chem. 2006, 34(5), 287-297.
    • (2006) Bioorg. Chem , vol.34 , Issue.5 , pp. 287-297
    • Mahale, S.1    Aubry, C.2    Jenkins, P.R.3    Marechal, J.D.4    Sutcliffe, M.J.5    Chaudhuri, B.6
  • 184
    • 0034642482 scopus 로고    scopus 로고
    • Binding Mode of the 4-Anilinoquinazoline Class of Protein Kinase Inhibitor: X-ray Crystallographic Studies of 4-Anilinoquinazolines Bound to Cyclin-Dependent Kinase 2 and p38 Kinase
    • Shewchuk, L.; Hassell, A.; Wisely, B.; Rocque, W.; Holmes, W.; Veal, J.; Kuyper, L. F. Binding Mode of the 4-Anilinoquinazoline Class of Protein Kinase Inhibitor: X-ray Crystallographic Studies of 4-Anilinoquinazolines Bound to Cyclin-Dependent Kinase 2 and p38 Kinase. J. Med. Chem. 2000, 43(1), 133-138.
    • (2000) J. Med. Chem , vol.43 , Issue.1 , pp. 133-138
    • Shewchuk, L.1    Hassell, A.2    Wisely, B.3    Rocque, W.4    Holmes, W.5    Veal, J.6    Kuyper, L.F.7
  • 185
    • 0037448375 scopus 로고    scopus 로고
    • Mettey, Y.; Gompel, M.; Thomas, V.; Garnier, M.; Leost, M.; Ceballos-Picot, I.; Noble, M.; Endicott, J.; Vierfond, J. M.; Meijer, L. Aloisines, a New Family of CDK/GSK-3 Inhibitors. SAR study, Crystal Structure in Complex with CDK2, Enzyme Selectivity, and Cellular Effects. J. Med. Chem. 2003, 46(2), 222-236.
    • Mettey, Y.; Gompel, M.; Thomas, V.; Garnier, M.; Leost, M.; Ceballos-Picot, I.; Noble, M.; Endicott, J.; Vierfond, J. M.; Meijer, L. Aloisines, a New Family of CDK/GSK-3 Inhibitors. SAR study, Crystal Structure in Complex with CDK2, Enzyme Selectivity, and Cellular Effects. J. Med. Chem. 2003, 46(2), 222-236.
  • 187
    • 0037315480 scopus 로고    scopus 로고
    • an Anticancer Sulfonamide in Clinical Development
    • Supuran, C. T. Indisulam: an Anticancer Sulfonamide in Clinical Development. Expert Opin. Investig. Drugs. 2003, 12(2), 283-287.
    • (2003) Expert Opin. Investig. Drugs , vol.12 , Issue.2 , pp. 283-287
    • Supuran, C.T.I.1
  • 188
    • 0034843846 scopus 로고    scopus 로고
    • Mechanisms of Action of the Novel Sulfonamide Anticancer Agent E7070 on Cell Cycle Progression in Human Non-Small Cell Lung Cancer Cells
    • Fukuoka, K.; Usuda, J.; Iwamoto, Y.; Fukumoto, H.; Nakamura, T.; Yoneda, T.; Narita, N.; Saijo, N.; Nishio, K. Mechanisms of Action of the Novel Sulfonamide Anticancer Agent E7070 on Cell Cycle Progression in Human Non-Small Cell Lung Cancer Cells. Invest. New Drugs 2001, 19(3), 219-227.
    • (2001) Invest. New Drugs , vol.19 , Issue.3 , pp. 219-227
    • Fukuoka, K.1    Usuda, J.2    Iwamoto, Y.3    Fukumoto, H.4    Nakamura, T.5    Yoneda, T.6    Narita, N.7    Saijo, N.8    Nishio, K.9
  • 190
    • 0348147633 scopus 로고    scopus 로고
    • Carbonic Anhydrase Inhibitors: E7070, a Sulfonamide Anticancer Agent, Potently Inhibits Cytosolic Isozymes I and II, and Transmembrane, Tumor-Associated Isozyme IX
    • Abbate, F.; Casini, A.; Owa, T.; Scozzafava, A.; Supuran, C. T. Carbonic Anhydrase Inhibitors: E7070, a Sulfonamide Anticancer Agent, Potently Inhibits Cytosolic Isozymes I and II, and Transmembrane, Tumor-Associated Isozyme IX. Bioorg. Med. Chem. Lett. 2004, 14(1), 217-223.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , Issue.1 , pp. 217-223
    • Abbate, F.1    Casini, A.2    Owa, T.3    Scozzafava, A.4    Supuran, C.T.5
  • 192
    • 21244505487 scopus 로고    scopus 로고
    • Lin, R.; Connolly, P. J.; Huang, S.; Wetter, S. K.; Lu, Y.; Murray, W. V.; Emanuel, S. L.; Gruninger, R. H.; Fuentes-Pesquera, A. R.; Rugg, C. A.; Middleton, S. A.; Jolliffe, L. K. 1-Acyl-1H-[1,2,4] triazole-3,5-diamine Analogues as Novel and Potent Anticancer Cyclin-Dependent Kinase Inhibitors: Synthesis and Evaluation of Biological Activities. J. Med. Chem. 2005, 48(13), 4208-4211.
    • Lin, R.; Connolly, P. J.; Huang, S.; Wetter, S. K.; Lu, Y.; Murray, W. V.; Emanuel, S. L.; Gruninger, R. H.; Fuentes-Pesquera, A. R.; Rugg, C. A.; Middleton, S. A.; Jolliffe, L. K. 1-Acyl-1H-[1,2,4] triazole-3,5-diamine Analogues as Novel and Potent Anticancer Cyclin-Dependent Kinase Inhibitors: Synthesis and Evaluation of Biological Activities. J. Med. Chem. 2005, 48(13), 4208-4211.
  • 194
    • 33746680509 scopus 로고    scopus 로고
    • Synthesis and Evaluation of N-acyl Sulfonamides as Potential Prodrugs of Cyclin-Dependent Kinase Inhibitor JNJ-7706621
    • Huang, S.; Connolly, P. J.; Lin, R.; Emanuel, S.; Middleton, S. A. Synthesis and Evaluation of N-acyl Sulfonamides as Potential Prodrugs of Cyclin-Dependent Kinase Inhibitor JNJ-7706621. Bioorg. Med. Chem. Lett. 2006, 16(14), 3639-3641.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , Issue.14 , pp. 3639-3641
    • Huang, S.1    Connolly, P.J.2    Lin, R.3    Emanuel, S.4    Middleton, S.A.5
  • 196
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from Phase III Clinical Trials on Anti-VEGF Therapy for Cancer
    • Jain, R. K.; Duda, D. G.; Clark, J. W.; Loeffler, J. S. Lessons from Phase III Clinical Trials on Anti-VEGF Therapy for Cancer. Nat. Clin. Pract. Oncol. 2006, 3(1), 24-40.
    • (2006) Nat. Clin. Pract. Oncol , vol.3 , Issue.1 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4


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