1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3β

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 2, 2004, Pages 413-416

  Kunick, Conrad ^a   Lauenroth, Kathrin ^b   Leost, Maryse ^c   Meijer, Laurent ^c   Lemcke, Thomas ^b  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c STATION BIOLOGIQUE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 AZAKENPAULLONE; 4 AZAKENPAULLONE; 5 IODOINDIRUBIN 3' MONOXIME; ALOISINE B; CYCLIN DEPENDENT KINASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; HYEMENIALDISINE; KENPAULLONE; PAULLONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG DISTRIBUTION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ELECTRICITY; ENZYME INHIBITION; MOLECULAR INTERACTION; STRUCTURE ANALYSIS;

EID: 0347360271     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.10.062     Document Type: Article

References (23)

1. Doble B.W., Woodgett J.R. J. Cell Sci. 116:2003;1175.
2. Woodgett J.R. EMBO J. 9:1990;2431.
3. Ali A., Hoeflich K.P., Woodgett J.R. Chem. Rev. 101:2001;2527.
4. Frame S., Cohen P. Biochem. J. 359:2001;1.
5. Cohen P. Phil. Trans. R. Soc. Lond. B. 354:1999;485.
6. Wagman A.S., Nuss J.M. Curr. Pharm. Des. 7:2001;417.
7. Naerum L., Norskov-Lauritsen L., Olesen P.H. Bioorg. Med. Chem. Lett. 12:2002;1525.
8. Martinez A., Alonso M., Castro A., Perez C., Moreno F. J. Med. Chem. 45:2002;1292.
9. Coghlan M.P., Culbert A.A., Cross D.A.E., Corcoran S.L., Yates J.D., Pearce N.J., Rausch O.L., Murphy G.J., Carter P.S., Cox L.R., Mills D., Brown M.J., Haigh D., Ward R.W., Smith D.G., Murray K.J., Reith A.D., Holder J. Chem. Biol. 7:2000;793.
10. Smith D.G., Buffet M., Fenwick A.E., Haigh D., Ife R.J., Saunders M., Slingsby B.P., Stacey R., Ward R.W. Bioorg. Med. Chem. Lett. 11:2001;635.
11. Martinez A., Castro A., Dorronsoro I., Alonso M. Med. Res. Rev. 22:2002;373.
12. Meijer L., Thunnissen A.-M.W.H., White A.W., Garnier M., Nikolic M., Tsai L.-H., Walter J., Cleverley K.E., Salinas P.C., Wu Y.-Z., Biernat J., Mandelkow E.M., Kim S.-H., Pettit G.R. Chem. Biol. 7:2000;51.
13. Leclerc S., Garnier M., Hoessel R., Marko D., Bibb J.A., Snyder G.L., Greengard P., Biernat J., Wu Y.-Z., Mandelkow E.-M., Eisenbrand G., Meijer L. J. Biol. Chem. 276:2001;251.
14. Mettey Y., Gompel M., Thomas V., Garnier M., Leost M., Ceballos-Picot I., Noble M., Endicott J., Vierfond J.-M., Meijer L. J. Med. Chem. 46:2003;222.
15. Leost M., Schultz C., Link A., Wu Y.-Z., Biernat J., Mandelkow E.-M., Bibb J.A., Snyder G.L., Greengard P., Zaharevitz D.W., Gussio R., Senderowicz A.M., Sausville E.A., Kunick C., Meijer L. Eur. J. Biochem. 267:2000;5983.
16. Bain J., McLauchlan H., Elliott M., Cohen P. Biochem. J. 371(Pt 1):2003;199.
17. Kunick C. Arch. Pharm. (Weinheim). 325:1992;297.
18. Fox H.H. J. Org. Chem. 17:1952;547.
19. Morgan D.O. Ann. Rev. Cell Dev. Biol. 13:1997;261.
20. Dhavan R., Tsai L.-H. Nature Rev. Mol. Cell Biol. 2:2001;749.
21. Tseng H.C., Zhou Y., Shen Y., Tsai L.H. FEBS Lett. 523:2002;58.
22. Gussio R., Zaharevitz D.W., McGrath C.F., Pattabiraman N., Kellogg G.E., Schultz C., Link A., Kunick C., Leost M., Meijer L., Sausville E.A. Anti-Cancer Drug Des. 15:2000;53.
23. SPARTAN, Vers. 5.0.1; Wavefunction Inc.: Irvine, USA, 1997.