Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): Design, synthesis, enzymatic activities, and X-ray crystallographic analysis

Journal of Medicinal Chemistry

Volumn 44, Issue 25, 2001, Pages 4339-4358

  Bramson, H N ^a   Holmes, W D ^a   Hunter, R N ^a   Lackey, K E ^a   Lovejoy, B ^a,b   Luzzio, M J ^a,c   Montana, V ^a   Rocque, W J ^a   Rusnak, D ^a   Shewchuk, L ^a   Veal, J M ^a   Corona, J ^a   Walker, D H ^a,d   Kuyper, L F ^a   Davis, S T ^a   Dickerson, S H ^a   Edelstein, M ^a   Frye, S V ^a   Gampe Jr , R T ^a   Harris, P A ^a   Hassell, A ^a   more..

^a GLAXOSMITHKLINE   (United States)

^b Pennie and Edmonds LLP   (United States)

^c PFIZER INC   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1H INDOLE 2,3 DIONE 3 PHENYLHYDRAZONE DERIVATIVE; 3 (ANILINOMETHYLENE) 1,3 DIHYDRO 2H INDOL 2 ONE DERIVATIVE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 2 INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; OXINDOLE; UNCLASSIFIED DRUG;

ALOPECIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; DNA SYNTHESIS; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG USE; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; PSORIASIS; RESTENOSIS; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CDC2-CDC28 KINASES; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; G1 PHASE; HUMANS; HYDRAZONES; INDOLES; ISATIN; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; S PHASE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TUMOR CELLS, CULTURED;

EID: 0035818942     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010117d     Document Type: Article

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