Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties

Journal of Medicinal Chemistry

Volumn 39, Issue 22, 1996, Pages 4471-4477

  Pereira, Elisabète Rodrigues ^a   Belin, Laure ^a   Sancelme, Martine ^a   Prudhomme, Michelle ^a   Ollier, Monique ^b   Rapp, Maryse ^b   Sevère, Danièle ^c   Riou, Jean François ^c   Fabbro, Doriano ^d   Meyer, Thomas ^d  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b INSERM   (France)

^c SANOFI   (France)

^d CIBA GEIGY LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; CARBAZOLE DERIVATIVE; DNA TOPOISOMERASE; K 252A; PROTEIN KINASE C INHIBITOR; REBECCAMYCIN; STAUROSPORINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CHLORINATION; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BACILLUS CEREUS; CARBAZOLES; DNA TOPOISOMERASES, TYPE I; ESCHERICHIA COLI; INDOLES; LEUKEMIA P388; MICE; MICROBIAL SENSITIVITY TESTS; PROTEIN KINASE C; STREPTOCOCCUS; TUMOR CELLS, CULTURED;

EID: 0000714445     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9603779     Document Type: Article

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