Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: Synthesis and biological effects

Journal of Medicinal Chemistry

Volumn 43, Issue 22, 2000, Pages 4126-4134

  Kim, K S ^a   Sack, J S ^a   Tokarski, J S ^a   Qian, L ^a   Chao, S T ^a   Leith, L ^a   Kelly, Y F ^a   Misra, R N ^a   Hunt, J T ^a   Kimball, S D ^a   Humphreys, W G ^a   Wautlet, B S ^a   Mulheron, J G ^a   Webster, K R ^a  

^a Department of Oncology Chemistry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 CHLOROPHENOXY) 5,7 DIHYDROXY 8 (3 HYDROXY 1 METHYL 4 PIPERIDINYL) 4H 1 BENZOPYRAN 4 ONE; 2 [(2 CHLOROPHENYL)THIO] 5,7 DIHYDROXY 8 (3 HYDROXY 1 METHYL 4 PIPERIDINYL) 4H 1 BENZOPYRAN 4 ONE; ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; ENZYME INHIBITOR; FLAVOPIRIDOL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; BINDING SITES; CDC2 PROTEIN KINASE; CDC2-CDC28 KINASES; CHROMONES; CRYSTALLOGRAPHY, X-RAY; CYCLIN B; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; FLAVONOIDS; HUMANS; MODELS, MOLECULAR; PIPERIDINES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 0034597571     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000231g     Document Type: Article

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