Synthesis and biological evaluation of 2-thiopyrimidine derivatives

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 9, 2005, Pages 3185-3195

  Sondhi, Sham M ^a   Goyal, Rajendra N ^a   Lahoti, Anand M ^a   Singh, Nirupma ^a   Shukla, Rakesh ^b   Raghubir, Ram ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

2 Thiopyrimidine derivatives; Analgesic; Anti inflammatory; Kinase inhibition; Synthesis; Isothiocyanatoketone

Indexed keywords

(4,4,6 TRIMETHYL 2 THIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)ACETIC ACID METHYL ESTER; (6 METHOXY 4 METHYL 2 THIOXOTETRAHYDROPYRIMIDIN 1 YL)ACETIC ACID METHYL ESTER; 1 (3 HYDROXYPYRIDIN 2 YL) 4,4,6 TRIMETHYL 3,4 DIHYDRO 1H PYRIMIDINE 2 THIONE; 2 METHYL 1,2,3,10A TETRAHYDRO 9H 10 OXA 3,4A DIAZAPHENANTHRENE 4 THIONE; 2 METHYL 1,2,3,9A TETRAHYDRO 9 OXA 3,4A,5 TRIAZAFLUORENE 4 THIONE; 3 METHYL 2,3,4,4A,9,10 HEXAHYDRO 2,9A,10 TRIAZAANTHRACENE 1 THIONE; 4 (4,4,6 TRIMETHYL 2 THIOXO 3,4 DIHYDRO 2H PYRIMIDIN 1 YL)BUTYRIC ACID; 4 (4,4,6 TRIMETHYL 2 THIOXO 3,4 DIHYDROPYRIMIDIN 1(2H) YL)BENZONITRILE; 4 (6 HYDROXY 4 METHYL 2 THIOXOTETRAHYDROPYRIMIDIN 1 YL)BUTYRIC ACID; 4,4' BIS(4,4,6 TRIMETHYL 3,4 DIHYDRO 1H PYRIMIDINE 2 THIOXO) BIPHENYLSULFONE; 4,4' BIS(4,4,6 TRIMETHYL 3,4 DIHYDRO 1H PYRIMIDINE 2 THIOXO)BIPHENYL; 4,4,6 TRIMETHYL 1 (2,2,6,6 TETRAMETHYLPIPERIDIN 4 YL) 3,4 DIHYDRO 1H PYRIMIDINE 2 THIONE; 7 (1 MERCAPTO 3,3,4A TRIMETHYL 4,4A,5,9B TETRAHYDRO 3H PYRIDO[4,3 B]INDOL 7 YL) 3,3,4A TRIMETHYL 3,4,4A,5 TETRAHYDROBENZ[4,5]IMIDAZO[1,2 C]PYRIMIDINE 1 THIOL; 7,7,8A TRIMETHYL 5 METHYLSULFANYL 8,8A DIHYDRO 7H OXAZOLO[3,2 C]PYRIMIDIN 2 YLIDENEAMINE; 7,7,8A TRIMETHYLHEXAHYDROTHIAZOLO[3,2 C]PYRIMIDINE 5 THIONE; ALKANONE; AMINE; BUTYRALDEHYDE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 5; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; INFLAMMATION; INFRARED SPECTROSCOPY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PAIN; PRODUCTIVITY; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 16244390244     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.02.047     Document Type: Article

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