Synthesis of novel 5-substituted indirubins as protein kinases inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 18, 2006, Pages 6434-6443

  Beauchard, Anne ^a   Ferandin, Yoan ^b   Frère, Stéphane ^a   Lozach, Olivier ^b   Blairvacq, Mélina ^b   Meijer, Laurent ^b   Thiéry, Valérie ^a   Besson, Thierry ^a  

^a FRE CNRS 2766   (France)

^b STATION BIOLOGIQUE DE ROSCOFF   (France)

Author keywords

Cyclin dependent kinase; Glycogen synthase kinase 3; Indirubin

Indexed keywords

1 METHYL 5 BROMOINDIRUBIN; 1 METHYL 5 NITROINDIRUBIN; 1 METHYL 5 NITROINDIRUBIN 3' OXIME; 1 METHYL 5' BROMO 5 NITROINDIRUBIN; 1 METHYL 5' BROMO 5 NITROINDIRUBIN 3' OXIME; 1 METHYLINDIRUBIN; 5 ACETAMIDO 5' BROMOINDIRUBIN; 5 ACETAMIDO 5' BROMOINDIRUBIN 3' OXIME; 5 ACETAMIDOINDIRUBIN; 5 ACETAMIDOINDIRUBIN 3' OXIME; 5 AMINO 5' BROMOINDIRUBIN; 5 AMINOINDIRUBIN; 5 AMINOINDIRUBIN 3' OXIME; 5 BROMOINDIRUBIN; 5 FLUOROINDIRUBIN; 5 NITROINDIRUBIN; 5 NITROINDIRUBIN 3' OXIME; 5' BROMO 1 METHYLINDIRUBIN; 5' BROMO 5 AMINOINDIRUBIN 3' OXIME; 5' BROMO 5 FLUOROINDIRUBIN; 5' BROMO 5 NITROINDIRUBIN; 5' BROMO 5 NITROINDIRUBIN 3' OXIME; 5,5' DIBROMOINDIRUBIN; CYCLIN B; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; INDIRUBIN; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; SUBSTITUTION REACTION;

ANIMALS; CDC2-CDC28 KINASES; CELL LINE, TUMOR; CELL SURVIVAL; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INDOLES; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PROTEIN KINASE INHIBITORS; STARFISH; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 33747364467     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.05.036     Document Type: Article

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