Crystallographic Approach to Identification of Cyclin-dependent Kinase 4 (CDK4)-specific Inhibitors by Using CDK4 Mimic CDK2 Protein

Journal of Biological Chemistry

Volumn 276, Issue 29, 2001, Pages 27548-27554

  Ikuta, Mari ^a   Kamata, Kenji ^a   Fukasawa, Kazuhiro ^a   Honma, Teruki ^a   Machida, Takumitsu ^a   Hirai, Hiroshi ^a   Suzuki Takahashi, Ikuko ^a   Hayama, Takashi ^a   Nishimura, Susumu ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOSYNTHESIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; TUMORS; X RAY CRYSTALLOGRAPHY;

ANTICANCER AGENTS; GENETIC ALTERATION;

ENZYMES;

CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 4 SPECIFIC INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN P16; UNCLASSIFIED DRUG; CYCLIN DEPENDENT KINASE; ENZYME INHIBITOR; ONCOPROTEIN;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; GENETIC ANALYSIS; HUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RETINOBLASTOMA; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; HYDROGEN BOND;

CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTO-ONCOGENE PROTEINS;

EID: 0035920248     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102060200     Document Type: Article

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