Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases

Journal of Medicinal Chemistry

Volumn 43, Issue 24, 2000, Pages 4606-4616

  Barvian, M ^a   Boschelli, D H ^a   Cossrow, J ^a   Dobrusin, E ^a   Fattaey, A ^b   Fritsch, A ^b   Fry, D ^a   Harvey, P ^a   Keller, P ^a   Garrett, M ^b   La, F ^a   Leopold, W ^a   McNamara, D ^a   Quin, M ^b   Trumpp Kallmeyer, S ^a   Toogood, P ^a   Wu, Z ^a   Zhang, E ^a  

^a PFIZER INC   (United States)

^b ONYX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 ETHYL 2 PHENYLAMINO 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; CYCLIN DEPENDENT KINASE INHIBITOR; PYRIDO[2,3 D]PYRIMIDIN 7 ONE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CELL DIVISION; CELL PROLIFERATION; DATA ANALYSIS; DNA REPLICATION; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CDC2-CDC28 KINASES; CELL DIVISION; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; ENZYME INHIBITORS; HUMANS; INSECTS; KINETICS; MODELS, MOLECULAR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PYRIMIDINES; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034736093     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000271k     Document Type: Article

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