7-hydroxystaurosporine (UCN-01) and ionizing radiation combine to inhibit the growth of Bcl-2-overexpressing U937 leukemia cells through a non-apoptotic mechanism.

International journal of oncology

Volumn 21, Issue 2, 2002, Pages 351-359

  Cartee, Leanne ^a   Sankala, Heidi ^a   Davis, Christine ^a   Smith, Rebecca ^a   Maggio, Sonia ^a   Lin, Peck Sun ^a   Dent, Paul ^a   Grant, Steven ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; 7-HYDROXYSTAUROSPORINE; ALKALOID; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; PROTEIN BCL 2; PROTEIN KINASE C; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIVISION; CELL MEMBRANE POTENTIAL; CELL STRAIN U937; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENETIC TRANSFECTION; HUMAN; IONIZING RADIATION; METABOLISM; MITOCHONDRION; MULTIMODALITY CANCER THERAPY; RADIATION EXPOSURE;

ALKALOIDS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIVISION; COMBINED MODALITY THERAPY; HUMANS; MEMBRANE POTENTIALS; MITOCHONDRIA; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION, IONIZING; STAUROSPORINE; TRANSFECTION; TUMOR STEM CELL ASSAY; U937 CELLS;

MLCS; MLOWN;

EID: 0036675996     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: 10.3892/ijo.21.2.351     Document Type: Article

References (0)