Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1)

Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2002, Pages 529-532

  Tasdemir, Deniz ^a,b   Mallon, Robert ^c   Greenstein, Michael ^c   Feldberg, Larry R ^c   Kim, Steven C ^c   Collins, Karen ^c   Wojciechowicz, Donald ^c   Mangalindan, Gina C ^d   Concepción, Gisela P ^d   Harper, Mary Kay ^a   Ireland, Chris M ^a  

^a UNIVERSITY OF UTAH   (United States)

^b HACETTEPE UNIVERSITY   (Turkey)

^c PFIZER INC   (United States)

^d University of the Philippines Diliman   (Philippines)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR;

ARTICLE; CELL PROLIFERATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; SPONGE (PORIFERA); STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; AZEPINES; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHILIPPINES; PHOSPHORYLATION; PORIFERA; PROTEIN-SERINE-THREONINE KINASES; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037122752     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0102856     Document Type: Article

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