Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts

Free Radical Biology and Medicine

Volumn 28, Issue 1, 2000, Pages 64-74

  Von Zglinicki, Thomas ^a   Pilger, Rita ^a   Sitte, Nicolle ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Aging; End replication problem; Fibroblasts; Free radical; Life span; Oxidative stress; Senescence; Telomeres

Indexed keywords

FREE RADICAL; HYDROGEN PEROXIDE;

AGING; ALKYLATION; ARTICLE; CONTROLLED STUDY; DNA STRAND BREAKAGE; FIBROBLAST; HUMAN; HUMAN CELL; LIFESPAN; OXIDATIVE STRESS; PEROXIDATION; PRIORITY JOURNAL; SENESCENCE; TELOMERE;

ALKYLATION; CELL AGING; CELL CYCLE; CELLS, CULTURED; DNA DAMAGE; DNA REPLICATION; DNA, SINGLE-STRANDED; FIBROBLASTS; HUMANS; HYDROGEN PEROXIDE; OXIDANTS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SPIN LABELS; TELOMERE;

EID: 0033954684     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(99)00207-5     Document Type: Article

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