A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA

Journal of Theoretical Biology

Volumn 213, Issue 4, 2001, Pages 573-586

  Sozou, Peter D ^a   Kirkwood, Thomas B L ^b  

^a LONDON SCHOOL OF ECONOMICS   (United Kingdom)

^b NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS DNA; MITOCHONDRIAL DNA; TELOMERASE;

CYTOLOGY; SENESCENCE;

ARTICLE; CELL AGING; CELL CLONE; CELL CULTURE; CELL CYCLE; CELL DIVISION; DIPLOIDY; FIBROBLAST; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIFESPAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; SIMULATION; SOMATIC MUTATION; STOCHASTIC MODEL; TELOMERE;

EID: 0035930836     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2001.2432     Document Type: Article

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