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Volumn 24, Issue 6, 1998, Pages 885-893

Accelerated telomere shortening in fibroblasts after extended periods of confluency

Author keywords

Aging; DNA damage; Fibroblasts; Free radical; Hayflick limit; Oxidative stress; S1 nuclease; Senescence; Single strand breaks; Telomeres

Indexed keywords

BROXURIDINE; FREE RADICAL; NUCLEASE S1; SINGLE STRANDED DNA;

EID: 0032054781     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(97)00363-8     Document Type: Article
Times cited : (141)

References (29)
  • 1
    • 0029563009 scopus 로고
    • Telomeres: Beginning to understand the end
    • Zakian V. A. Telomeres Beginning to understand the end . Science. 270:1995;1601-1607.
    • (1995) Science , vol.270 , pp. 1601-1607
    • Zakian, V.A.1
  • 2
    • 0025787643 scopus 로고
    • Telomere loss: Mitotic clock or genetic time bomb?
    • Harley C. B. Telomere loss Mitotic clock or genetic time bomb? Mutat. Res. 256:1991;271-282.
    • (1991) Mutat. Res. , vol.256 , pp. 271-282
    • Harley, C.B.1
  • 3
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37:1965;614-636.
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 4
    • 0026680249 scopus 로고
    • The two-stage mechanism controlling cellular senescence and immortalization
    • Wright W. E., Shay J. W. The two-stage mechanism controlling cellular senescence and immortalization. Exp. Gerontol. 27:1992;383-389.
    • (1992) Exp. Gerontol. , vol.27 , pp. 383-389
    • Wright, W.E.1    Shay, J.W.2
  • 6
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan T. M., Englezou A., Gupta J., Bacchetti S., Reddel R. R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14:1995;4240-4248.
    • (1995) EMBO J. , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 7
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • Lundblad V., Szostak J. W. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell. 57:1989;633-643.
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 9
    • 0015844590 scopus 로고
    • A theory of marginotomy: The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
    • Olovnikov A. M. A theory of marginotomy The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon . J. Theor. Biol. 41:1973;181-190.
    • (1973) J. Theor. Biol. , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 10
    • 0029953557 scopus 로고    scopus 로고
    • Evidence for a new step in telomere maintainance
    • Wellinger R. J., Ethier K., Labrecque P., Zakian V. A. Evidence for a new step in telomere maintainance. Cell. 85:1996;423-433.
    • (1996) Cell , vol.85 , pp. 423-433
    • Wellinger, R.J.1    Ethier, K.2    Labrecque, P.3    Zakian, V.A.4
  • 11
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov V. L., Hirose Y., Langmore J. P. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell. 88:1997;657-666.
    • (1997) Cell , vol.88 , pp. 657-666
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 12
    • 0029127226 scopus 로고
    • Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: A model for senescence?
    • von Zglinicki T., Saretzki G., Döcke W., Lotze C. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts A model for senescence? Exp. Cell Res. 220:1995;186-193.
    • (1995) Exp. Cell Res. , vol.220 , pp. 186-193
    • Von Zglinicki, T.1    Saretzki, G.2    Döcke, W.3    Lotze, C.4
  • 13
    • 0027163464 scopus 로고
    • Replicative senescence of human fibroblast-like cells in culture
    • Cristofalo V. J., Pignolo R. J. Replicative senescence of human fibroblast-like cells in culture. Physiol. Rev. 73:1993;617-638.
    • (1993) Physiol. Rev. , vol.73 , pp. 617-638
    • Cristofalo, V.J.1    Pignolo, R.J.2
  • 14
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley C. B., Futcher A. B., Greider C. W. Telomeres shorten during ageing of human fibroblasts. Nature. 345:1990;458-460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 16
    • 0023018781 scopus 로고
    • Quantitation of radiation-, chemical-, or enzyme-induced single strand breaks in nonradioactive DNA by alkaline gel electrophoresis: Application to pyrimidine dimers
    • Freeman S. E., Blackett A. D., Monteleone D. C., Setlow R. B., Sutherland B. M., Sutherland J. C. Quantitation of radiation-, chemical-, or enzyme-induced single strand breaks in nonradioactive DNA by alkaline gel electrophoresis application to pyrimidine dimers . Anal. Biochem. 158:1986;119-129.
    • (1986) Anal. Biochem. , vol.158 , pp. 119-129
    • Freeman, S.E.1    Blackett, A.D.2    Monteleone, D.C.3    Setlow, R.B.4    Sutherland, B.M.5    Sutherland, J.C.6
  • 17
    • 0016253034 scopus 로고
    • Maintenance of human diploid fibroblasts as arrested populations
    • Dell Orco R. T. Maintenance of human diploid fibroblasts as arrested populations. Fed Proc. 33:1974;1969-1972.
    • (1974) Fed Proc. , vol.33 , pp. 1969-1972
    • Dell Orco, R.T.1
  • 18
    • 0015939496 scopus 로고
    • Senescence of human cells in culture
    • Holliday R. Senescence of human cells in culture. Nature. 242:1973;332-333.
    • (1973) Nature , vol.242 , pp. 332-333
    • Holliday, R.1
  • 19
    • 0016313121 scopus 로고
    • Senescence of cultured human fibroblasts: Mitotic versus metabolic time
    • Goldstein S., Singal D. P. Senescence of cultured human fibroblasts Mitotic versus metabolic time . Exp. Cell Res. 88:1974;359-364.
    • (1974) Exp. Cell Res. , vol.88 , pp. 359-364
    • Goldstein, S.1    Singal, D.P.2
  • 21
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal R. S., Weindruch R. Oxidative stress, caloric restriction, and aging. Science. 273:1996;59-63.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 22
    • 0014257476 scopus 로고
    • The division potential of cells in continuous growth as compared to cells subcultivated after maintainance in stationary phase
    • Hay R. J., Menzies R. A., Morgan H. P., Strehler B. L. The division potential of cells in continuous growth as compared to cells subcultivated after maintainance in stationary phase. Exp. Gerontol. 3:1968;35-44.
    • (1968) Exp. Gerontol. , vol.3 , pp. 35-44
    • Hay, R.J.1    Menzies, R.A.2    Morgan, H.P.3    Strehler, B.L.4
  • 23
    • 0019311707 scopus 로고
    • A low density inoculation method for the serial subcultivation of human diploid fibroblasts: An efficient model for the study of cellular aging
    • Kaji K., Matsuo M. A low density inoculation method for the serial subcultivation of human diploid fibroblasts An efficient model for the study of cellular aging . Mech. Ageing Dev. 13:1980;219-225.
    • (1980) Mech. Ageing Dev. , vol.13 , pp. 219-225
    • Kaji, K.1    Matsuo, M.2
  • 24
    • 0029877289 scopus 로고    scopus 로고
    • Cellular aging, destabilization, and cancer
    • Rubin H., Chow M., Yao A. Cellular aging, destabilization, and cancer. Proc. Natl. Acad. Sci. USA. 93:1996;1825-1830.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 1825-1830
    • Rubin, H.1    Chow, M.2    Yao, A.3
  • 25
    • 0029847817 scopus 로고    scopus 로고
    • Irreversibility of cellular aging and neoplastic transformation: A clonal analysis
    • Chow M., Rubin H. Irreversibility of cellular aging and neoplastic transformation A clonal analysis . Proc. Natl. Acad. Sci. USA. 93:1996;9793-9798.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9793-9798
    • Chow, M.1    Rubin, H.2
  • 26
    • 0017738651 scopus 로고
    • The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro
    • Balin A. K., Goodman D. P. B., Rasmussen H., Cristofalo V. J. The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro. J. Cell. Biol. 74:1977;58-67.
    • (1977) J. Cell. Biol. , vol.74 , pp. 58-67
    • Balin, A.K.1    Goodman, D.P.B.2    Rasmussen, H.3    Cristofalo, V.J.4
  • 27
    • 0017405185 scopus 로고
    • Low oxygen concentration extends the lifespan of cultured human diploid cells
    • Packer L., Fuehr K. Low oxygen concentration extends the lifespan of cultured human diploid cells. Nature. 267:1977;423-425.
    • (1977) Nature , vol.267 , pp. 423-425
    • Packer, L.1    Fuehr, K.2
  • 29
    • 0029145379 scopus 로고
    • Evidence for a critical telomere length in senescent human fibroblasts
    • Allsopp R. C., Harley C. B. Evidence for a critical telomere length in senescent human fibroblasts. Exp. Cell Res. 219:1995;130-136.
    • (1995) Exp. Cell Res. , vol.219 , pp. 130-136
    • Allsopp, R.C.1    Harley, C.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.