Molecular manifestations and molecular determinants of telomere capping

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 65, Issue , 2000, Pages 253-263

  Blackburn, E H ^a   Chan, S ^a   Chang, J ^a   Fulton, T B ^a   Krauskopf, A ^d   Mceachern, M ^d   Prescott, J ^b   Roy, J ^a   Smith, C ^a   Wang, H ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Sunesis Pharmaceuticals Inc   (United States)

^c Michigan State University ^*  (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

TELOMERASE; RAP1 PROTEIN;

CAPPING PHENOMENON; CELL PROLIFERATION; CONFERENCE PAPER; CONFORMATIONAL TRANSITION; DNA BINDING; DNA DAMAGE; DNA STRUCTURE; GENE FUSION; GENETIC RECOMBINATION; LONG TERMINAL REPEAT; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; STRUCTURE ANALYSIS; TELOMERE; ANIMAL; GENETICS; HUMAN; METABOLISM; REVIEW; ARTICLE; CHROMOSOME STRUCTURE; DNA DAMAGE RESPONSE; DNA PROTEIN COMPLEX; ENZYME REGULATION; PROTEIN BINDING; TELOMERE HOMEOSTASIS; WILD TYPE;

ANIMAL; DNA DAMAGE; HUMAN; SUPPORT, U.S. GOV'T, P.H.S.; TELOMERASE; TELOMERE;

EID: 0034437351     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2000.65.253     Document Type: Conference Paper

References (94)

1. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
2. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae
3. Identification of a telomere-binding activity from yeast
4. Telomeres and double-strand breaks: Trying to make ends meet
5. Telomeres: No end in sight
6. Telomerase
7. The telomere and telomerase: How do they interact?
8. Non-nucleosomal packaging of a tandemly repeated DNA sequence at termini of extrachromosomal DNA coding for rRNA in Tetrahymena
9. The molecular structure of centromeres and telomeres
10. Functional characterization and developmental regulation of mouse telomerase RNA
11. Extension of lifespan by introduction of telomerase into normal human cells
12. Chromatin structure of the telomeric region and 3′-nontranscribed spacer of Tetrahymena ribosomal RNA genes
13. DNA-binding properties of the replication telomere protein
14. Two types of telomeric chromatin in Tetrahymena thermophila
15. RAP1 protein interacts with yeast telomeres in vivo: Overproduction alters telomere structure and decreases chromosome stability
16. Regulation of telomere length and function by a Myb-domain protein in fission yeast
17. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
18. Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase
19. Telomeres and telomerase: At the end, it all comes together
20. Telomere proteins
21. The RNA component of human telomerase
22. Identification of Kluyveromyces lactis telomerase: Discontinuous synthesis along the 30-nucleotide-long templating domain
23. Nuclear pore complexes in the organization of silent telomeric chromatin
24. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
25. Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites
26. Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: Phased nucleosomes and a telomeric complex
27. Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
28. Yeast Ku as a regulator of chromosomal DNA end structure
29. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
30. Characterisation of the DNA binding domain of the yeast RAP1 protein
31. Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA
32. Ku is associated with the telomere in mammals
33. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
34. Kinetics of in vitro aging of mouse embryo fibroblasts
35. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
36. The Mre11p/Rad50p/Xrs2p complex and the Te11p function in a single pathway for telomere maintenance in yeast
37. Block in anaphase chromosome separation caused by a telomerase template mutation
38. Antisense telomerase treatment: Induction of two distinct pathways, apoptosis and differentiation
39. Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
40. Rap1 protein regulates telomere turnover in yeast
41. RAP1 protein activates and silences transcription of mating-type genes in yeast
42. C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae
43. RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae
44. Heterogeneity in telomere length of human chromosomes
45. Dynamics of telomere length variation in Tetrahymena thermophila
46. RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
47. Conserved nucleoprotein structure at the ends of vertebrate and invertebrate chromosomes
48. Identification of human Rap1: Implications for telomere evolution
49. Mutational analysis defines a C-terminal tail domain of RAP1 essential for telomeric silencing in Saccharomyces cerevisiae
50. - senescence
51. A protein-counting mechanism for telomere length regulation in yeast
52. Runaway telomere elongation caused by telomerase RNA gene mutations
53. Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase
54. Telomere fusions caused by mutating the terminal region of telomeric DNA
55. Sensor-less checkpoint activation?
56. Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
57. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres
58. A quantitative analysis of the aging of human glial cells in culture
59. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro
60. Functionally interacting telomerase RNAs in the yeast telomerase complex
61. Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres
62. Immortalized cells with no detectable telomerase activity
63. Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage
64. Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
65. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae
66. Specific telomerase RNA residues distant from the template are essential for telomerase function
67. Loss of a yeast telomere: Arrest, recovery, and chromosome loss
68. Self-assembly, self-organization and division of labour
69. Generation of telomere-length heterogeneity in Saccharomyces cerevisiae
70. Functional evidence for an RNA template in telomerase
71. RAP1: A protean regulator in yeast
72. Telomere position effects and transcriptional silencing in the yeast Saccharomyces cerevisiae
73. Telomerase and telomere-binding proteins: Controlling the endgame
74. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements
75. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
76. Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
77. Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
78. Control of human telomere length by TRF1 and TRF2
79. The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena
80. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
81. Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: Isolation of viable mutants affecting both silencing and telomere length
82. An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing
83. Unusual chromatin in human telomeres
84. TRF2 protects human telomeres from end-to-end fusions
85. Telomere processing in Euplotes
86. Est1 has the properties of a single-stranded telomere end-binding protein
87. Three telomerases with completely non-telomeric template replacements are catalytically active
88. Evidence for a new step in telomere maintenance
89. A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1 p to regulate telomere length in Saccharomyces cerevisiae
90. Saccharomyces telomeres assume a non-nucleosomal chromatin structure
91. Structure and function of telomeres
92. Telomeres: Beginning to understand the end
93. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening