Interactions between respiratory tract infections and atopy in the aetiology of asthma

European Respiratory Journal

Volumn 19, Issue 3, 2002, Pages 538-545

  Holt, P G ^a   Sly, P D ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Asthma; Atopy; Bacterial stimuli; Cytokines; Viral infection

Indexed keywords

ALLERGEN; CD14 ANTIGEN;

ALLERGIC ASTHMA; ANIMAL CELL; ARTICLE; BACTERIAL INFECTION; BRONCHIOLITIS; CELL KINETICS; CELL MATURATION; CHILD; CONTACT SENSITIZATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA POLYMORPHISM; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENCE; INFANCY; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PERINATAL PERIOD; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; RISK ASSESSMENT; TH1 CELL; TH2 CELL; VIRUS INFECTION;

ADULT; ALLERGENS; ASTHMA; CHILD; CHILD, PRESCHOOL; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; HYPERSENSITIVITY; IMMUNITY, CELLULAR; IMMUNOLOGIC MEMORY; INFANT; MALE; PROGNOSIS; RESPIRATORY TRACT INFECTIONS; RISK ASSESSMENT; RISK FACTORS; TH1 CELLS; TH2 CELLS;

EID: 0036196657     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.02.00229302     Document Type: Article

References (72)

1. Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients
2. Human TH1 and TH2 subsets: Doubt no more
3. Dermatophagoides pteronyssinus II-induced interleukin-4 and interferon-γ expression by freshly isolated lymphocytes of atopic individuals
4. Clonal diversity of IL-4 and IL-13 expression in human allergen-specific T lymphocytes
5. TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
6. Th1/Th2 lymphocytes: Doubt some more
7. Regulation of cytokine production in T-cell responses to inhalant allergen: GATA-3 expression distinguishes between Th1 and Th2-polarised immunity
8. Cord blood lymphocyte responses to food antigens for the prediction of allergic disorders
9. Aeroallergen sensitization can occur during fetal life
10. Cord blood mononuclear cell responsiveness to beta-lactoglobulin: T-cell activity in "atopy-prone" and "non-atopy-prone" newborns
11. Maternofetal interaction and allergy
12. T-cell "priming" against environmental allergens in human neonates: Sequential deletion of food antigen specificities during infancy with concomitant expansion of responses to ubiquitous inhalant allergens
13. Transplacental priming of the human immune system to environmental allergens: Universal skewing of initial T-cell responses towards the Th-2 cytokine profile
14. Development of allergen-specific T-cell memory in atopic and normal children
15. Abnormal production of T helper 2 cytokines interleukin-4 and interleukin-5 by T cells from newborns with atopic parents
16. Peripheral blood mononuclear cell proliferative responses in the first year of life in babies born to allergic parents
17. Th-2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood
18. Regulation of Th-cell responses to inhalant allergen during early childhood
19. Is the increase in asthma prevalence linked to increase in allergen load?
20. Genetic 'risk' for atopy is associated with delayed postnatal maturation of T-cell competence
21. Interferon-γ production by cord-blood mononuclear cells is reduced in newborns with a family history of atopic disease and is independent from cord blood IgE-levels
22. Reduced interferon-γ secretion in neonates and subsequent atopy
23. Decreased production of IFNγ and increased production of IL-6 by cord blood mononuclear cells of newborns with a high risk of allergy
24. Association of interleukin-2 and interferon-γ production by blood mononuclear cells in infancy with parental allergy skin tests and with subsequent development of atopy
25. Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema?
26. Fetal and neonatal IL-13 production during pregnancy and at birth and subsequent development of atopic symptoms
27. Development of long term tolerance versus sensitisation to environmental allergens during the perinatal period
28. Environmental factors and primary T-cell sensitisation to inhalant allergens in infancy: Reappraisal. of the role of infections and air pollution
29. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction
30. Inverse association between tuberculin responses and atopic disorder
31. Atopic versus infectious diseases in childhood: A question of balance?
32. Exposure of foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: Epidemiological study
33. A polymorphism in the 5′-flanking region of the CD14 gene is associated with circulating soluble CD14 levels with total serum IgE
34. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
35. Reduced risk of hay fever and asthma amongst children of farmers
36. Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma
37. The relationship between upper respiratory infections and hospital admissions for asthma: A time-trend analysis
38. Asthma and wheezing in the first six years of life
39. The relationship of RSV-specific immunoglobulin E antibody responses in infancy, recurrent wheezing, and pulmonary function at age 7-8 years
40. Asthma: Prognosis
41. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years
42. Eliminating a region of respiratory syncytial virus attachment protein allows induction of protective immunity without vaccine-enhanced lung eosinophilia
43. Asthma and immunoglobulin E antibodies after respiratory syncytial virus bronchiolitis: A prospective cohort study with matched controls
44. Serum IgE levels in white and Metis communities in Saskatchewan
45. Hay fever, hygiene, and household size
46. Role of viral infections in the inception of asthma and allergies during childhood: Could they be protective?
47. Infections and the development of allergy
48. Association of non-wheezing lower respiratory tract illnesses in early life with persistently diminished serum IgE levels
49. Atopic sensitisation and respiratory symptoms among Polish and Swedish school children
50. Regulation of immunological homeostasis in peripheral tissues by dendritic cells: The respiratory tract as a paradigm
51. Resting respiratory tract dendritic cells preferentially stimulate Th2 responses and require obligatory cytokine signals for induction of Th1 immunity
52. Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli
53. Development of the airway intraepithelial dendritic cell network in the rat from class II MHC (Ia) negative precursors: Differential regulation of Ia expression at different levels of the respiratory tract
54. Defective regional immunity in the respiratory tract of neonates is attributable to hyporesponsiveness of local dendritic cells to activation signals
55. Dendritic cells in the mucosa of the human trachea are not regularly found in the first year of life
56. T-cells and eosinophils in the pathogenesis of asthma
57. The inflammation-repair cycle in asthma: The pivotal role of the airway epithelium
58. The role of allergy in the development of asthma
59. Longitudinal changes in atopy during a 4-year period: Relation to bronchial hyperresponsiveness and respiratory symptoms in a population sample of Australian schoolchildren
60. Early senstization to allergens and development of respiratory symptoms
61. Family history of atopy and clinical course of RSV infection in ambulatory and hospitalized infants
62. Measles history and atopic diseases: A population-based cross-sectional study
63. Antecedents of childhood asthma: Respiratory infections, atopy and breast-feeding have independent and multiplicative effects
64. Cellular immunity is activated and a Th-2 response is associated with early wheezing in infants after bronchiolitis
65. Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response
66. Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis
67. Reduced interferon-γ expression in peripheral blood mononuclear cells of infants with severe respiratory syncytial virus disease
68. Reduced interferon-γ production in infants with bronchiolitis and asthma
69. Predominant type-2 response in infants with respiratory syncytial virus (RSV) infection demonstrated by cytokine flow cytometry
70. Decreased interleukin-12 levels in umbilical cord blood in children who developed acute bronchiolitis
71. Non-atopic wheezy children have reduced interferon-gamma
72. Heterogeneity in DTaP vaccine-specific cellular immunity during infancy: Relationship to variations in the kinetics of postnatal maturation of systemic Th1 function