PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27KIP1 through the ubiquitin E3 ligase SCFSKP2

Current Biology

Volumn 11, Issue 4, 2001, Pages 263-267

  Mamillapalli, Ramanaiah ^a   Gavrilova, Nadia ^a   Mihaylova, Valia T ^a   Tsvetkov, Lyuben M ^a   Wu, Hong ^b   Zhang, Hui ^a   Sun, Hong ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0035916325     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00065-3     Document Type: Article

References (12)

1. Genetics of Cowden syndrome: Through the looking glass of oncology
2. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
3. PTEN/MMAC1/TEP1 suppresses the tumorigenecity and induces G1 cell cycle arrest in human glioblastoma cells
4. PTEN modulates cell cycle progression and cell survival by regulating PIP3 and Akt/PKB signaling pathway
5. p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated thr187 in p27
6. p45(Skp2) promotes p27(Kip1) degradation and induces S phase in quiescent cells
7. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
8. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
9. The lipid phosphatase activity of PTEN is critical for its tumor supressor function
10. Cyclin E-CDK2 is a regulator of p27Kip1
11. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
12. CDK inhibitors: Positive and negative regulators of G1-phase progression