Control of cell cycle exit and entry by protein kinase B-regulated Forkhead transcription factors

Molecular and Cellular Biology

Volumn 22, Issue 7, 2002, Pages 2025-2036

  Kops, Geert J P L ^a   Medema, Rene H ^a   Glassford, Janet ^a   Essers, Marieke A G ^a   Dijkers, Pascale F ^a   Coffer, Paul J ^a   Lam, Eric W F ^a   Burgering, Boudewijn M T ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P27; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOOD PROTEINS; CELL AGING; CELL CYCLE; CELL CYCLE PROTEINS; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FORKHEAD TRANSCRIPTION FACTORS; GENE DELETION; GENE EXPRESSION REGULATION; HUMANS; MICE; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RETINOBLASTOMA-LIKE PROTEIN P130; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 0036120725     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.7.2025-2036.2002     Document Type: Article

References (59)

1. Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver
2. Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer
3. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ra
4. p21ras: An oncoprotein functioning in growth factor-induced signal transduction
5. Transforming growth factor-β1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo
6. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
7. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)
8. The retinoblastoma-like protein p130 is involved in the determination of reserve cells in differentiating myoblasts
9. Adenoviral RB2/p130 gene transfer inhibits smooth muscle cell proliferation and prevents restenosis after angioplasty
10. Kip1-deficient cells
11. Protein kinase B (c-Akt): A multifunctional mediator of phosphatidylinositol 3-kinase activation
12. Inhibition of the phosphoinositide 3-kinase pathway induces a senescencelike arrest mediated by p27Kip1
13. 1 control causing immortalization and increased cell turnover under growth-restricting conditions
14. The multiple roles of PTEN in tumor suppression
15. Expression of the pro-apoptotic bcl-2 family member bim is regulated by the forkhead transcription factor FKHR-L1
16. KIP1
17. Phosphoinositide kinases
18. Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells
19. Transcriptional repression of the E2F-1 gene by interferonalpha is mediated through induction of E2F-4/pRB and E2F-4/p130 complexes
20. Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
21. Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth
22. Activation of NF-κB determines the sensitivity of human colon cancer cells to TNFα-induced apoptosis
23. 1 block
24. E2F4 is essential for normal erythrocyte maturation and neonatal viability
25. Transcription factors Oct-1 and NF-YA regulate the p53-independent induction of the GADD45 following DNA damage
26. Phenotype vs. genotype in the evolution of astrocytic brain tumors
27. Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
28. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt
29. Direct control of the Forkhead transcription factor AFX by protein kinase B
30. Regulation of exit from quiescence by p27 and cyclin D1-CDK4
31. daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
32. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins
33. kip1: A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
34. Kip1 allows cell proliferation in the postnatal and adult organ of corti
35. Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p130
36. 0 lead to its association with E2F-4
37. Specific activation of p85-p110 phosphatidylinositol 3′-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways
38. kip1
39. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
40. Expression and modulation of p42/p44 MAPKs and cell cycle regulatory proteins in rat pancreas regeneration
41. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A
42. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN
43. The molecular genetics of central nervous system tumors
44. The Forkhead transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
45. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
46. 1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
47. Phosphorylation of the transcription factor Forkhead family member FKHR by protein kinase B
48. 0 state) in fibroblasts
49. An element in intron 1 of the CFTR gene augments intestinal expression in vivo
50. Cancer cell cycles
51. 1 cell state
52. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
53. Expression of the retinoblastoma-related gene Rb2/p13O correlates with clinical outcome in endometrial cancer
54. Chemosensory regulation of development in C. elegans
55. 0 to S phase transition in human primary B-lymphocytes
56. A pivotal role of cyclin D3 and cyclin-dependent kinase inhibitor p27 in the regulation of IL-2-, IL-4-, or IL-10-mediated human B cell proliferation
57. E2F-Rb complexes assemble and inhibit cdc25A transcription in cervical carcinoma cells following repression of human papillomavirus oncogene expression
58. ARF locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors
59. p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F