p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase

Cancer Research

Volumn 65, Issue 9, 2005, Pages 3745-3750

  Zhao, Yunfeng ^a   Chaiswing, Luksana ^b   Velez, Joyce M ^a   Batinic Haberle, Ines ^c   Colburn, Nancy H ^d   Oberley, Terry D ^b   St Clair, Daret K ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; MANGANESE SUPEROXIDE DISMUTASE; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN BAX; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BAX GENE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; EPIDERMIS CELL; FLOW CYTOMETRY; FLUORESCENCE; GEL MOBILITY SHIFT ASSAY; GENE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SKIN CARCINOGENESIS; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BIOMIMETIC MATERIALS; CELL LINE; CELL NUCLEUS; DNA; IMMUNOHISTOCHEMISTRY; METALLOPORPHYRINS; MICE; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; SKIN; SKIN NEOPLASMS; SUPEROXIDE DISMUTASE; TETRADECANOYLPHORBOL ACETATE; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53;

EID: 18144382261     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3835     Document Type: Article

References (27)

1. Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59:527-605.
2. Halliwell B, Gutteridge JM. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys 1986:246:501-14.
3. Fridovich I. Superoxide radical and superoxide dismutases. Annu Rev Biochem 1995;64:97-112.
4. Li Y, Huang TT, Carlson EJ, et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese SOD. Nat Genet 1995;11:376-81.
5. Lebovitz RM, Zhang H, Vogel H, et al. Neurodegeneration, myocardial injury and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci USA 1996;93:9782-7.
6. Lane DP. Cancer: p53, guardian of the genome. Nature 1992;358:15-6.
7. Tokino T, Nakamura Y. The role of p53-target genes in human cancer. Crit Rev Oncol Hematol 2000;33:1-6.
8. Moll UM, Zaika A. Nuclear and mitochondrial apoptotic pathways of p53. FEBS Lett 2001;493:65-9.
9. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature 1997;389:300-5.
10. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995;80:293-9.
11. Oda E, Ohki K, Murasawa H, et al. Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 2000;288:1053-8.
12. Oda K, Arakawa H, Tanaka T, et al. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-16-phosphorylated p53. Cell 2000;102:849-62.
13. Li PF, Dietz R, von Harsdorf R. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. EMBO J 1999;18:6027-36.
14. Marchenko ND, Zaika AI, Moll UM. Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling. J Biol Chem 2000;275:16202-12.
15. Erster S, Mihara M, Kim RH, Petrenko O, Moll UM. In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation. Mol Cell Biol 2004;24:6728-41.
16. Zhao Y, Xue Y. Oberley TD, et al. Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogcnesis model. Cancer Res 2001;61:6082-8.
17. Zhao Y, Oberley TD, Chaiswing L, et al. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-I and p53-mediated pathways in a skin cancer model. Oncogene 2002;21:3836-46.
18. Colburn NH. Former HF, Nelson KA, Yuspa SH. Tumour promoter induces anchorage independence irreversibly. Nature 1979;281:589-91.
19. Spitz DR, Oberley LW. An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem 1989;195:133-40.
20. Reid S, Cross K. Snow EC. Combined Hoechst 33342 and merocyanine 540 staining to examine murine B cell cycle stage, viability and apoptosis. J Immunol Methods 1996;192:43-54.
21. Caelles C. Helmberg A. Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 1994;370:220-3.
22. Mihara M, Erster S, Zaika A, et al. p53 has a direct apoptogenic role at the mitochondria. Mol Cell 2003;11:577-90.
23. Chipuk JE, Kuwana T, Bouchier-Hayes L, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004;303:1010-4.
24. Porntadavity S, Xu Y, Kiningham K, et al. TPA-activated transcription of the human MnSOD gene: role of transcription factors SP-1 and Egr-1. DNA Cell Biol 2001;20:473-81.
25. Fujii J, Taniguchi N. Phorbol ester induces manganese-superoxide dismutase in tumor necrosis factor-resistant cells. J Biol Chem 1991;266:23142-6.
26. Batinic-Haberle I, Spasojevic I, Hambright P, Benov L, Crumbliss AL, Fridovich I. Relationship among redox potentials, proton dissociation constants of pyrrolic nitrogens, and in vivo and in vitro superoxide dismuting activities of manganese(III) and iron(III) water-soluble prophyrins. Inorg Chem 1999;38:4011-22.
27. Katsumoto T, Higaki K, Phno K, Onodera K. Cell-cycle dependent biosynthesis and localization of p53 protein in untransformed human cells. Biol Cell 1995;84:167-73.