-
1
-
-
77957055780
-
Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein coupled receptors
-
Ballesteros J.A., and Weinstein H. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein coupled receptors. Methods Neurosci. 25 (1995) 366-428
-
(1995)
Methods Neurosci.
, vol.25
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
2
-
-
17644402459
-
Transduction of receptor signals by beta-arrestins
-
Lefkowitz R.J., and Shenoy S.K. Transduction of receptor signals by beta-arrestins. Science 308 5721 (2005) 512-517
-
(2005)
Science
, vol.308
, Issue.5721
, pp. 512-517
-
-
Lefkowitz, R.J.1
Shenoy, S.K.2
-
3
-
-
0036473397
-
The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals
-
Luttrell L.M., and Lefkowitz R.J. The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. J. Cell. Sci. 115 Pt. 3 (2002) 455-465
-
(2002)
J. Cell. Sci.
, vol.115
, Issue.PART 3
, pp. 455-465
-
-
Luttrell, L.M.1
Lefkowitz, R.J.2
-
4
-
-
0141593597
-
Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors
-
Azzi M., Charest P.G., Angers S., Rousseau G., Kohout T., Bouvier M., and Pineyro G. Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors. Proc. Natl. Acad. Sci. U. S. A. 100 20 (2003) 11406-11411
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, Issue.20
, pp. 11406-11411
-
-
Azzi, M.1
Charest, P.G.2
Angers, S.3
Rousseau, G.4
Kohout, T.5
Bouvier, M.6
Pineyro, G.7
-
5
-
-
0038024615
-
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints
-
Fredriksson R., Lagerstrom M.C., Lundin L.G., and Schioth H.B. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol. Pharmacol. 63 6 (2003) 1256-1272
-
(2003)
Mol. Pharmacol.
, vol.63
, Issue.6
, pp. 1256-1272
-
-
Fredriksson, R.1
Lagerstrom, M.C.2
Lundin, L.G.3
Schioth, H.B.4
-
6
-
-
0035283073
-
Orphan G-protein-coupled receptors and natural ligand discovery
-
Howard A.D., McAllister G., Feighner S.D., Liu Q., Nargund R.P., Van der Ploeg L.H., and Patchett A.A. Orphan G-protein-coupled receptors and natural ligand discovery. Trends Pharmacol. Sci. 22 3 (2001) 132-140
-
(2001)
Trends Pharmacol. Sci.
, vol.22
, Issue.3
, pp. 132-140
-
-
Howard, A.D.1
McAllister, G.2
Feighner, S.D.3
Liu, Q.4
Nargund, R.P.5
Van der Ploeg, L.H.6
Patchett, A.A.7
-
7
-
-
0032504237
-
G protein-coupled receptors. I. Diversity of receptor-ligand interactions
-
Ji T.H., Grossmann M., and Ji I. G protein-coupled receptors. I. Diversity of receptor-ligand interactions. J. Biol. Chem. 273 28 (1998) 17299-17302
-
(1998)
J. Biol. Chem.
, vol.273
, Issue.28
, pp. 17299-17302
-
-
Ji, T.H.1
Grossmann, M.2
Ji, I.3
-
8
-
-
0038662595
-
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
-
Pin J.P., Galvez T., and Prezeau L. Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors. Pharmacol. Ther. 98 3 (2003) 325-354
-
(2003)
Pharmacol. Ther.
, vol.98
, Issue.3
, pp. 325-354
-
-
Pin, J.P.1
Galvez, T.2
Prezeau, L.3
-
9
-
-
0035818605
-
Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site
-
Knoflach F., Mutel V., Jolidon S., Kew J.N., Malherbe P., Vieira E., Wichmann J., and Kemp J.A. Positive allosteric modulators of metabotropic glutamate 1 receptor: characterization, mechanism of action, and binding site. Proc. Natl. Acad. Sci. U. S. A. 98 23 (2001) 13402-13407
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, Issue.23
, pp. 13402-13407
-
-
Knoflach, F.1
Mutel, V.2
Jolidon, S.3
Kew, J.N.4
Malherbe, P.5
Vieira, E.6
Wichmann, J.7
Kemp, J.A.8
-
10
-
-
0035028011
-
BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity
-
Carroll F.Y., Stolle A., Beart P.M., Voerste A., Brabet I., Mauler F., Joly C., Antonicek H., Bockaert J., Muller T., Pin J.P., and Prezeau L. BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol. Pharmacol. 59 5 (2001) 965-973
-
(2001)
Mol. Pharmacol.
, vol.59
, Issue.5
, pp. 965-973
-
-
Carroll, F.Y.1
Stolle, A.2
Beart, P.M.3
Voerste, A.4
Brabet, I.5
Mauler, F.6
Joly, C.7
Antonicek, H.8
Bockaert, J.9
Muller, T.10
Pin, J.P.11
Prezeau, L.12
-
11
-
-
0034721795
-
The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors
-
Pagano A., Ruegg D., Litschig S., Stoehr N., Stierlin C., Heinrich M., Floersheim P., Prezeau L., Carroll F., Pin J.P., Cambria A., Vranesic I., Flor P.J., Gasparini F., and Kuhn R. The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors. J. Biol. Chem. 275 43 (2000) 33750-33758
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.43
, pp. 33750-33758
-
-
Pagano, A.1
Ruegg, D.2
Litschig, S.3
Stoehr, N.4
Stierlin, C.5
Heinrich, M.6
Floersheim, P.7
Prezeau, L.8
Carroll, F.9
Pin, J.P.10
Cambria, A.11
Vranesic, I.12
Flor, P.J.13
Gasparini, F.14
Kuhn, R.15
-
12
-
-
0033028258
-
CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding
-
Litschig S., Gasparini F., Rueegg D., Stoehr N., Flor P.J., Vranesic I., Prezeau L., Pin J.P., Thomsen C., and Kuhn R. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Mol. Pharmacol. 55 3 (1999) 453-461
-
(1999)
Mol. Pharmacol.
, vol.55
, Issue.3
, pp. 453-461
-
-
Litschig, S.1
Gasparini, F.2
Rueegg, D.3
Stoehr, N.4
Flor, P.J.5
Vranesic, I.6
Prezeau, L.7
Pin, J.P.8
Thomsen, C.9
Kuhn, R.10
-
13
-
-
27744560413
-
Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+)
-
Ray K., Tisdale J., Dodd R.H., Dauban P., Ruat M., and Northup J.K. Calindol, a positive allosteric modulator of the human Ca(2+) receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca(2+). J. Biol. Chem. 280 44 (2005) 37013-37020
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.44
, pp. 37013-37020
-
-
Ray, K.1
Tisdale, J.2
Dodd, R.H.3
Dauban, P.4
Ruat, M.5
Northup, J.K.6
-
14
-
-
0037166287
-
Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor
-
Ray K., and Northup J. Evidence for distinct cation and calcimimetic compound (NPS 568) recognition domains in the transmembrane regions of the human Ca2+ receptor. J. Biol. Chem. 277 21 (2002) 18908-18913
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.21
, pp. 18908-18913
-
-
Ray, K.1
Northup, J.2
-
15
-
-
0347379900
-
The three-dimensional structure of bovine rhodopsin determined by electron cryomicroscopy
-
Krebs A., Edwards P.C., Villa C., Li J., and Schertler G.F. The three-dimensional structure of bovine rhodopsin determined by electron cryomicroscopy. J. Biol. Chem. (2003) 50217-50225
-
(2003)
J. Biol. Chem.
, pp. 50217-50225
-
-
Krebs, A.1
Edwards, P.C.2
Villa, C.3
Li, J.4
Schertler, G.F.5
-
16
-
-
0032500697
-
Characterisation of an improved two-dimensional p22121 crystal from bovine rhodopsin
-
Krebs A., Villa C., Edwards P.C., and Schertler G.F. Characterisation of an improved two-dimensional p22121 crystal from bovine rhodopsin. J. Mol. Biol. 282 5 (1998) 991-1003
-
(1998)
J. Mol. Biol.
, vol.282
, Issue.5
, pp. 991-1003
-
-
Krebs, A.1
Villa, C.2
Edwards, P.C.3
Schertler, G.F.4
-
17
-
-
0031847518
-
Structure of rhodopsin
-
Schertler G.F. Structure of rhodopsin. Eye 12 Pt. 3b (1998) 504-510
-
(1998)
Eye
, vol.12
, Issue.PART 3b
, pp. 504-510
-
-
Schertler, G.F.1
-
18
-
-
0030775615
-
Arrangement of rhodopsin transmembrane alpha-helices
-
Unger V.M., Hargrave P.A., Baldwin J.M., and Schertler G.F. Arrangement of rhodopsin transmembrane alpha-helices. Nature 389 6647 (1997) 203-206
-
(1997)
Nature
, vol.389
, Issue.6647
, pp. 203-206
-
-
Unger, V.M.1
Hargrave, P.A.2
Baldwin, J.M.3
Schertler, G.F.4
-
19
-
-
0027190359
-
Projection structure of rhodopsin
-
Schertler G.F., Villa C., and Henderson R. Projection structure of rhodopsin. Nature 362 6422 (1993) 770-772
-
(1993)
Nature
, vol.362
, Issue.6422
, pp. 770-772
-
-
Schertler, G.F.1
Villa, C.2
Henderson, R.3
-
20
-
-
0031565726
-
An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors
-
Baldwin J.M., Schertler G.F., and Unger V.M. An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors. J. Mol. Biol. 272 1 (1997) 144-164
-
(1997)
J. Mol. Biol.
, vol.272
, Issue.1
, pp. 144-164
-
-
Baldwin, J.M.1
Schertler, G.F.2
Unger, V.M.3
-
21
-
-
0343081370
-
X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles
-
Okada T., Le Trong I., Fox B.A., Behnke C.A., Stenkamp R.E., and Palczewski K. X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles. J. Struct. Biol. 130 1 (2000) 73-80
-
(2000)
J. Struct. Biol.
, vol.130
, Issue.1
, pp. 73-80
-
-
Okada, T.1
Le Trong, I.2
Fox, B.A.3
Behnke, C.A.4
Stenkamp, R.E.5
Palczewski, K.6
-
22
-
-
0034604451
-
Crystal structure of rhodopsin: a G protein-coupled receptor [see comments]
-
Palczewski K., Kumasaka T., Hori T., Behnke C.A., Motoshima H., Fox B.A., Le Trong I., Teller D.C., Okada T., Stenkamp R.E., Yamamoto M., and Miyano M. Crystal structure of rhodopsin: a G protein-coupled receptor [see comments]. Science 289 5480 (2000) 739-745
-
(2000)
Science
, vol.289
, Issue.5480
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
23
-
-
0037197848
-
Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography
-
Okada T., Fujiyoshi Y., Silow M., Navarro J., Landau E.M., and Shichida Y. Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography. Proc. Natl. Acad. Sci. U. S. A. 99 9 (2002) 5982-5987
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, Issue.9
, pp. 5982-5987
-
-
Okada, T.1
Fujiyoshi, Y.2
Silow, M.3
Navarro, J.4
Landau, E.M.5
Shichida, Y.6
-
24
-
-
0035800032
-
Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs)
-
Teller D.C., Okada T., Behnke C.A., Palczewski K., and Stenkamp R.E. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry 40 26 (2001) 7761-7772
-
(2001)
Biochemistry
, vol.40
, Issue.26
, pp. 7761-7772
-
-
Teller, D.C.1
Okada, T.2
Behnke, C.A.3
Palczewski, K.4
Stenkamp, R.E.5
-
25
-
-
4344581120
-
The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
-
Okada T., Sugihara M., Bondar A.N., Elstner M., Entel P., and Buss V. The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J. Mol. Biol. 342 2 (2004) 571-583
-
(2004)
J. Mol. Biol.
, vol.342
, Issue.2
, pp. 571-583
-
-
Okada, T.1
Sugihara, M.2
Bondar, A.N.3
Elstner, M.4
Entel, P.5
Buss, V.6
-
26
-
-
6344248639
-
Structure of bovine rhodopsin in a trigonal crystal form
-
Li J., Edwards P.C., Burghammer M., Villa C., and Schertler G.F. Structure of bovine rhodopsin in a trigonal crystal form. J. Mol. Biol. 343 5 (2004) 1409-1438
-
(2004)
J. Mol. Biol.
, vol.343
, Issue.5
, pp. 1409-1438
-
-
Li, J.1
Edwards, P.C.2
Burghammer, M.3
Villa, C.4
Schertler, G.F.5
-
27
-
-
0032059717
-
Highly selective separation of rhodopsin from bovine rod outer segment membranes using combination of divalent cation and alkyl(thio)glucoside
-
Okada T., Takeda K., and Kouyama T. Highly selective separation of rhodopsin from bovine rod outer segment membranes using combination of divalent cation and alkyl(thio)glucoside. Photochem. Photobiol. 67 5 (1998) 495-499
-
(1998)
Photochem. Photobiol.
, vol.67
, Issue.5
, pp. 495-499
-
-
Okada, T.1
Takeda, K.2
Kouyama, T.3
-
28
-
-
6344227960
-
Crystals of native and modified bovine rhodopsins and their heavy atom derivatives
-
Edwards P.C., Li J., Burghammer M., McDowell J.H., Villa C., Hargrave P.A., and Schertler G.F. Crystals of native and modified bovine rhodopsins and their heavy atom derivatives. J. Mol. Biol. 343 5 (2004) 1439-1450
-
(2004)
J. Mol. Biol.
, vol.343
, Issue.5
, pp. 1439-1450
-
-
Edwards, P.C.1
Li, J.2
Burghammer, M.3
McDowell, J.H.4
Villa, C.5
Hargrave, P.A.6
Schertler, G.F.7
-
29
-
-
23044486642
-
Structure of rhodopsin and the metarhodopsin I photointermediate
-
Schertler G.F. Structure of rhodopsin and the metarhodopsin I photointermediate. Curr. Opin. Struct. Biol. 15 4 (2005) 408-415
-
(2005)
Curr. Opin. Struct. Biol.
, vol.15
, Issue.4
, pp. 408-415
-
-
Schertler, G.F.1
-
30
-
-
12744280744
-
Structure of human follicle-stimulating hormone in complex with its receptor
-
Fan Q.R., and Hendrickson W.A. Structure of human follicle-stimulating hormone in complex with its receptor. Nature 433 7023 (2005) 269-277
-
(2005)
Nature
, vol.433
, Issue.7023
, pp. 269-277
-
-
Fan, Q.R.1
Hendrickson, W.A.2
-
31
-
-
0036169280
-
The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop
-
Shi L., and Javitch J.A. The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop. Annu. Rev. Pharmacol. Toxicol. 42 (2002) 437-467
-
(2002)
Annu. Rev. Pharmacol. Toxicol.
, vol.42
, pp. 437-467
-
-
Shi, L.1
Javitch, J.A.2
-
32
-
-
0030954433
-
Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors
-
Elling C.E., Thirstrup K., Nielsen S.M., Hjorth S.A., and Schwartz T.W. Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors. Ann. N. Y. Acad. Sci. 814 (1997) 142-151
-
(1997)
Ann. N. Y. Acad. Sci.
, vol.814
, pp. 142-151
-
-
Elling, C.E.1
Thirstrup, K.2
Nielsen, S.M.3
Hjorth, S.A.4
Schwartz, T.W.5
-
33
-
-
0034948696
-
Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors
-
Ballesteros J.A., Shi L., and Javitch J.A. Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors. Mol. Pharmacol. 60 1 (2001) 1-19
-
(2001)
Mol. Pharmacol.
, vol.60
, Issue.1
, pp. 1-19
-
-
Ballesteros, J.A.1
Shi, L.2
Javitch, J.A.3
-
34
-
-
0037215651
-
Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors?
-
Archer E., Maigret B., Escrieut C., Pradayrol L., and Fourmy D. Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors?. Trends Pharmacol. Sci. 24 1 (2003) 36-40
-
(2003)
Trends Pharmacol. Sci.
, vol.24
, Issue.1
, pp. 36-40
-
-
Archer, E.1
Maigret, B.2
Escrieut, C.3
Pradayrol, L.4
Fourmy, D.5
-
35
-
-
0030298385
-
Heterologous expression of G-protein-coupled receptors
-
Tate C.G., and Grisshammer R. Heterologous expression of G-protein-coupled receptors. Trends Biotechnol. 14 11 (1996) 426-430
-
(1996)
Trends Biotechnol.
, vol.14
, Issue.11
, pp. 426-430
-
-
Tate, C.G.1
Grisshammer, R.2
-
36
-
-
0037450572
-
G protein-coupled receptor overexpression with the baculovirus-insect cell system: a tool for structural and functional studies
-
Massotte D. G protein-coupled receptor overexpression with the baculovirus-insect cell system: a tool for structural and functional studies. Biochim. Biophys. Acta. 1610 1 (2003) 77-89
-
(2003)
Biochim. Biophys. Acta.
, vol.1610
, Issue.1
, pp. 77-89
-
-
Massotte, D.1
-
37
-
-
0041876269
-
Heterologous expression of G-protein-coupled receptors: comparison of expression systems fron the standpoint of large-scale production and purification
-
Sarramegna V., Talmont F., Demange P., and Milon A. Heterologous expression of G-protein-coupled receptors: comparison of expression systems fron the standpoint of large-scale production and purification. Cell. Mol. Life Sci. 60 8 (2003) 1529-1546
-
(2003)
Cell. Mol. Life Sci.
, vol.60
, Issue.8
, pp. 1529-1546
-
-
Sarramegna, V.1
Talmont, F.2
Demange, P.3
Milon, A.4
-
38
-
-
0033378616
-
Improved purification of a rat neurotensin receptor expressed in Escherichia coli
-
Grisshammer R., Averbeck P., and Sohal A.K. Improved purification of a rat neurotensin receptor expressed in Escherichia coli. Biochem. Soc. Trans. 27 6 (1999) 899-903
-
(1999)
Biochem. Soc. Trans.
, vol.27
, Issue.6
, pp. 899-903
-
-
Grisshammer, R.1
Averbeck, P.2
Sohal, A.K.3
-
39
-
-
12244292640
-
Purification and characterization of the human adenosine A(2a) receptor functionally expressed in Escherichia coli
-
Weiss H.M., and Grisshammer R. Purification and characterization of the human adenosine A(2a) receptor functionally expressed in Escherichia coli. Eur. J. Biochem. 269 1 (2002) 82-92
-
(2002)
Eur. J. Biochem.
, vol.269
, Issue.1
, pp. 82-92
-
-
Weiss, H.M.1
Grisshammer, R.2
-
40
-
-
0037648337
-
Structure-based analysis of GPCR function: conformational adaptation of both agonist and receptor upon leukotriene B4 binding to recombinant BLT1
-
Baneres J.L., Martin A., Hullot P., Girard J.P., Rossi J.C., and Parello J. Structure-based analysis of GPCR function: conformational adaptation of both agonist and receptor upon leukotriene B4 binding to recombinant BLT1. J. Mol. Biol. 329 4 (2003) 801-814
-
(2003)
J. Mol. Biol.
, vol.329
, Issue.4
, pp. 801-814
-
-
Baneres, J.L.1
Martin, A.2
Hullot, P.3
Girard, J.P.4
Rossi, J.C.5
Parello, J.6
-
42
-
-
0035816704
-
Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor
-
Ghanouni P., Gryczynski Z., Steenhuis J.J., Lee T.W., Farrens D.L., Lakowicz J.R., and Kobilka B.K. Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor. J. Biol. Chem. 276 27 (2001) 24433-24436
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.27
, pp. 24433-24436
-
-
Ghanouni, P.1
Gryczynski, Z.2
Steenhuis, J.J.3
Lee, T.W.4
Farrens, D.L.5
Lakowicz, J.R.6
Kobilka, B.K.7
-
43
-
-
0036174608
-
Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function
-
Angers S., Salahpour A., and Bouvier M. Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function. Annu. Rev. Pharmacol. Toxicol. 42 (2002) 409-435
-
(2002)
Annu. Rev. Pharmacol. Toxicol.
, vol.42
, pp. 409-435
-
-
Angers, S.1
Salahpour, A.2
Bouvier, M.3
-
44
-
-
0035478438
-
Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking
-
Devi L.A. Heterodimerization of G-protein-coupled receptors: pharmacology, signaling and trafficking. Trends Pharmacol. Sci. 22 10 (2001) 532-537
-
(2001)
Trends Pharmacol. Sci.
, vol.22
, Issue.10
, pp. 532-537
-
-
Devi, L.A.1
-
45
-
-
14644387575
-
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
-
Bulenger S., Marullo S., and Bouvier M. Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol. Sci. 26 3 (2005) 131-137
-
(2005)
Trends Pharmacol. Sci.
, vol.26
, Issue.3
, pp. 131-137
-
-
Bulenger, S.1
Marullo, S.2
Bouvier, M.3
-
46
-
-
6944237210
-
The ants go marching two by two: oligomeric structure of G-protein-coupled receptors
-
Javitch J.A. The ants go marching two by two: oligomeric structure of G-protein-coupled receptors. Mol. Pharmacol. 66 5 (2004) 1077-1082
-
(2004)
Mol. Pharmacol.
, vol.66
, Issue.5
, pp. 1077-1082
-
-
Javitch, J.A.1
-
47
-
-
3042628452
-
The activation mechanism of class-C G-protein coupled receptors
-
Pin J.P., Kniazeff J., Goudet C., Bessis A.S., Liu J., Galvez T., Acher F., Rondard P., and Prezeau L. The activation mechanism of class-C G-protein coupled receptors. Biol. Cell 96 5 (2004) 335-342
-
(2004)
Biol. Cell
, vol.96
, Issue.5
, pp. 335-342
-
-
Pin, J.P.1
Kniazeff, J.2
Goudet, C.3
Bessis, A.S.4
Liu, J.5
Galvez, T.6
Acher, F.7
Rondard, P.8
Prezeau, L.9
-
48
-
-
0034718925
-
Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
-
Kunishima N., Shimada Y., Tsuji Y., Sato T., Yamamoto M., Kumasaka T., Nakanishi S., Jingami H., and Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407 6807 (2000) 971-977
-
(2000)
Nature
, vol.407
, Issue.6807
, pp. 971-977
-
-
Kunishima, N.1
Shimada, Y.2
Tsuji, Y.3
Sato, T.4
Yamamoto, M.5
Kumasaka, T.6
Nakanishi, S.7
Jingami, H.8
Morikawa, K.9
-
49
-
-
0037022586
-
Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+
-
Tsuchiya D., Kunishima N., Kamiya N., Jingami H., and Morikawa K. Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+. Proc. Natl. Acad. Sci. U. S. A. 99 5 (2002) 2660-2665
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, Issue.5
, pp. 2660-2665
-
-
Tsuchiya, D.1
Kunishima, N.2
Kamiya, N.3
Jingami, H.4
Morikawa, K.5
-
50
-
-
0038159530
-
Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes
-
Liang Y., Fotiadis D., Filipek S., Saperstein D.A., Palczewski K., and Engel A. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J. Biol. Chem. 278 24 (2003) 21655-21662
-
(2003)
J. Biol. Chem.
, vol.278
, Issue.24
, pp. 21655-21662
-
-
Liang, Y.1
Fotiadis, D.2
Filipek, S.3
Saperstein, D.A.4
Palczewski, K.5
Engel, A.6
-
51
-
-
0038392702
-
Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein
-
Baneres J.L., and Parello J. Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein. J. Mol. Biol. 329 4 (2003) 815-829
-
(2003)
J. Mol. Biol.
, vol.329
, Issue.4
, pp. 815-829
-
-
Baneres, J.L.1
Parello, J.2
-
52
-
-
9644255747
-
Cooperative conformational changes in a G-protein-coupled receptor dimer, the leukotriene B(4) receptor BLT1
-
Mesnier D., and Baneres J.L. Cooperative conformational changes in a G-protein-coupled receptor dimer, the leukotriene B(4) receptor BLT1. J. Biol. Chem. 279 48 (2004) 49664-49670
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.48
, pp. 49664-49670
-
-
Mesnier, D.1
Baneres, J.L.2
-
53
-
-
0036532207
-
Structure of rhodopsin and the superfamily of seven-helical receptors: the same and not the same
-
Sakmar T.P. Structure of rhodopsin and the superfamily of seven-helical receptors: the same and not the same. Curr. Opin. Cell Biol. 14 2 (2002) 189-195
-
(2002)
Curr. Opin. Cell Biol.
, vol.14
, Issue.2
, pp. 189-195
-
-
Sakmar, T.P.1
-
54
-
-
0026341233
-
The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa
-
Sakmar T.P., Franke R.R., and Khorana H.G. The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa. Proc. Natl. Acad. Sci. U. S. A. 88 8 (1991) 3079-3083
-
(1991)
Proc. Natl. Acad. Sci. U. S. A.
, vol.88
, Issue.8
, pp. 3079-3083
-
-
Sakmar, T.P.1
Franke, R.R.2
Khorana, H.G.3
-
55
-
-
0642306488
-
Phototransduction: crystal clear
-
Ridge K.D., Abdulaev N.G., Sousa M., and Palczewski K. Phototransduction: crystal clear. Trends Biochem. Sci. 28 9 (2003) 479-487
-
(2003)
Trends Biochem. Sci.
, vol.28
, Issue.9
, pp. 479-487
-
-
Ridge, K.D.1
Abdulaev, N.G.2
Sousa, M.3
Palczewski, K.4
-
56
-
-
0037285444
-
Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking
-
Hubbell W.L., Altenbach C., Hubbell C.M., and Khorana H.G. Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking. Adv. Protein Chem. 63 (2003) 243-290
-
(2003)
Adv. Protein Chem.
, vol.63
, pp. 243-290
-
-
Hubbell, W.L.1
Altenbach, C.2
Hubbell, C.M.3
Khorana, H.G.4
-
57
-
-
0029907599
-
Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin
-
Farrens D.L., Altenbach C., Yang K., Hubbell W.L., and Khorana H.G. Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin. Science 274 5288 (1996) 768-770
-
(1996)
Science
, vol.274
, Issue.5288
, pp. 768-770
-
-
Farrens, D.L.1
Altenbach, C.2
Yang, K.3
Hubbell, W.L.4
Khorana, H.G.5
-
58
-
-
0033555936
-
Conformational changes in rhodopsin. Movement of helix f detected by site-specific chemical labeling and fluorescence spectroscopy
-
Dunham T.D., and Farrens D.L. Conformational changes in rhodopsin. Movement of helix f detected by site-specific chemical labeling and fluorescence spectroscopy. J. Biol. Chem. 274 3 (1999) 1683-1690
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.3
, pp. 1683-1690
-
-
Dunham, T.D.1
Farrens, D.L.2
-
59
-
-
0029756165
-
Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state
-
Lin S.W., and Sakmar T.P. Specific tryptophan UV-absorbance changes are probes of the transition of rhodopsin to its active state. Biochemistry 35 34 (1996) 11149-11159
-
(1996)
Biochemistry
, vol.35
, Issue.34
, pp. 11149-11159
-
-
Lin, S.W.1
Sakmar, T.P.2
-
60
-
-
0029778268
-
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F
-
Sheikh S.P., Zvyaga T.A., Lichtarge O., Sakmar T.P., and Bourne H.R. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature 383 6598 (1996) 347-350
-
(1996)
Nature
, vol.383
, Issue.6598
, pp. 347-350
-
-
Sheikh, S.P.1
Zvyaga, T.A.2
Lichtarge, O.3
Sakmar, T.P.4
Bourne, H.R.5
-
61
-
-
0035951062
-
Structure and function in rhodopsin: mapping light-dependent changes in distance between residue 316 in helix 8 and residues in the sequence 60-75, covering the cytoplasmic end of helices TM1 and TM2 and their connection loop CL1
-
Altenbach C., Klein-Seetharaman J., Cai K., Khorana H.G., and Hubbell W.L. Structure and function in rhodopsin: mapping light-dependent changes in distance between residue 316 in helix 8 and residues in the sequence 60-75, covering the cytoplasmic end of helices TM1 and TM2 and their connection loop CL1. Biochemistry 40 51 (2001) 15493-15500
-
(2001)
Biochemistry
, vol.40
, Issue.51
, pp. 15493-15500
-
-
Altenbach, C.1
Klein-Seetharaman, J.2
Cai, K.3
Khorana, H.G.4
Hubbell, W.L.5
-
62
-
-
0033594981
-
Structural features and light-dependent changes in the sequence 59-75 connecting helices I and II in rhodopsin: a site-directed spin-labeling study
-
Altenbach C., Klein-Seetharaman J., Hwa J., Khorana H.G., and Hubbell W.L. Structural features and light-dependent changes in the sequence 59-75 connecting helices I and II in rhodopsin: a site-directed spin-labeling study. Biochemistry 38 25 (1999) 7945-7949
-
(1999)
Biochemistry
, vol.38
, Issue.25
, pp. 7945-7949
-
-
Altenbach, C.1
Klein-Seetharaman, J.2
Hwa, J.3
Khorana, H.G.4
Hubbell, W.L.5
-
63
-
-
0033594988
-
Structural features and light-dependent changes in the sequence 306-322 extending from helix VII to the palmitoylation sites in rhodopsin: a site-directed spin-labeling study
-
Altenbach C., Cai K., Khorana H.G., and Hubbell W.L. Structural features and light-dependent changes in the sequence 306-322 extending from helix VII to the palmitoylation sites in rhodopsin: a site-directed spin-labeling study. Biochemistry 38 25 (1999) 7931-7937
-
(1999)
Biochemistry
, vol.38
, Issue.25
, pp. 7931-7937
-
-
Altenbach, C.1
Cai, K.2
Khorana, H.G.3
Hubbell, W.L.4
-
64
-
-
5044235587
-
Electron crystallography reveals the structure of metarhodopsin I
-
Ruprecht J.J., Mielke T., Vogel R., Villa C., and Schertler G.F. Electron crystallography reveals the structure of metarhodopsin I. EMBO J. 23 18 (2004) 3609-3620
-
(2004)
EMBO J.
, vol.23
, Issue.18
, pp. 3609-3620
-
-
Ruprecht, J.J.1
Mielke, T.2
Vogel, R.3
Villa, C.4
Schertler, G.F.5
-
65
-
-
33751019133
-
Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals
-
Salom D., Le Trong I., Pohl E., Ballesteros J.A., Stenkamp R.E., Palczewski K., and Lodowski D.T. Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals. J. Struct. Biol. (2006) 497-504
-
(2006)
J. Struct. Biol.
, pp. 497-504
-
-
Salom, D.1
Le Trong, I.2
Pohl, E.3
Ballesteros, J.A.4
Stenkamp, R.E.5
Palczewski, K.6
Lodowski, D.T.7
-
66
-
-
0037452868
-
Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin
-
Mirzadegan T., Benko G., Filipek S., and Palczewski K. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry 42 10 (2003) 2759-2767
-
(2003)
Biochemistry
, vol.42
, Issue.10
, pp. 2759-2767
-
-
Mirzadegan, T.1
Benko, G.2
Filipek, S.3
Palczewski, K.4
-
67
-
-
0021928722
-
Specificity of the functional interactions of the b-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles
-
Cerione R.A., Staniszewski C., Benovic J.L., Lefkowitz R.J., Caron M.G., Gierschik P., Somers R., Spiegel A.M., Codina J., and Birnbaumer L. Specificity of the functional interactions of the b-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles. J. Biol. Chem. 260 3 (1985) 1493-1500
-
(1985)
J. Biol. Chem.
, vol.260
, Issue.3
, pp. 1493-1500
-
-
Cerione, R.A.1
Staniszewski, C.2
Benovic, J.L.3
Lefkowitz, R.J.4
Caron, M.G.5
Gierschik, P.6
Somers, R.7
Spiegel, A.M.8
Codina, J.9
Birnbaumer, L.10
-
68
-
-
0030859541
-
Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor
-
Gether U., Lin S., Ghanouni P., Ballesteros J.A., Weinstein H., and Kobilka B.K. Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor. EMBO J. 16 22 (1997) 6737-6747
-
(1997)
EMBO J.
, vol.16
, Issue.22
, pp. 6737-6747
-
-
Gether, U.1
Lin, S.2
Ghanouni, P.3
Ballesteros, J.A.4
Weinstein, H.5
Kobilka, B.K.6
-
69
-
-
0035937786
-
Agonist-induced conformational changes at the cytoplasmic side of TM 6 in the {beta}2 adrenergic receptor mapped by site-selective fluorescent labeling
-
(p. Record as supplied by publisher)
-
Jensen A.D., Guarnieri F., Rasmussen S.G., Asmar F., Ballesteros J.A., and Gether U. Agonist-induced conformational changes at the cytoplasmic side of TM 6 in the {beta}2 adrenergic receptor mapped by site-selective fluorescent labeling. J. Biol. Chem. (2000) 9279-9290 (p. Record as supplied by publisher)
-
(2000)
J. Biol. Chem.
, pp. 9279-9290
-
-
Jensen, A.D.1
Guarnieri, F.2
Rasmussen, S.G.3
Asmar, F.4
Ballesteros, J.A.5
Gether, U.6
-
70
-
-
0035932989
-
Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor
-
Ghanouni P., Steenhuis J.J., Farrens D.L., and Kobilka B.K. Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor. Proc. Natl. Acad. Sci. U. S. A. 98 11 (2001) 5997-6002
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, Issue.11
, pp. 5997-6002
-
-
Ghanouni, P.1
Steenhuis, J.J.2
Farrens, D.L.3
Kobilka, B.K.4
-
71
-
-
33746382921
-
Coupling ligand structure to specific conformational switches in the beta(2)-adrenoceptor
-
Yao X., Parnot C., Deupi X., Ratnala V.R., Swaminath G., Farrens D., and Kobilka B. Coupling ligand structure to specific conformational switches in the beta(2)-adrenoceptor. Nat. Chem. Biol. (2006) 417-422
-
(2006)
Nat. Chem. Biol.
, pp. 417-422
-
-
Yao, X.1
Parnot, C.2
Deupi, X.3
Ratnala, V.R.4
Swaminath, G.5
Farrens, D.6
Kobilka, B.7
-
72
-
-
0033546197
-
Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation
-
Sheikh S.P., Vilardarga J.P., Baranski T.J., Lichtarge O., Iiri T., Meng E.C., Nissenson R.A., and Bourne H.R. Similar structures and shared switch mechanisms of the beta2-adrenoceptor and the parathyroid hormone receptor. Zn(II) bridges between helices III and VI block activation. J. Biol. Chem. 274 24 (1999) 17033-17041
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.24
, pp. 17033-17041
-
-
Sheikh, S.P.1
Vilardarga, J.P.2
Baranski, T.J.3
Lichtarge, O.4
Iiri, T.5
Meng, E.C.6
Nissenson, R.A.7
Bourne, H.R.8
-
73
-
-
33745224117
-
Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation
-
Elling C.E., Frimurer T.M., Gerlach L.O., Jorgensen R., Holst B., and Schwartz T.W. Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. J. Biol. Chem. 281 25 (2006) 17337-17346
-
(2006)
J. Biol. Chem.
, vol.281
, Issue.25
, pp. 17337-17346
-
-
Elling, C.E.1
Frimurer, T.M.2
Gerlach, L.O.3
Jorgensen, R.4
Holst, B.5
Schwartz, T.W.6
-
74
-
-
0030611331
-
Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment
-
Javitch J.A., Fu D., Liapakis G., and Chen J. Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment. J. Biol. Chem. 272 30 (1997) 18546-18549
-
(1997)
J. Biol. Chem.
, vol.272
, Issue.30
, pp. 18546-18549
-
-
Javitch, J.A.1
Fu, D.2
Liapakis, G.3
Chen, J.4
-
75
-
-
0033061256
-
Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6
-
Rasmussen S.G., Jensen A.D., Liapakis G., Ghanouni P., Javitch J.A., and Gether U. Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6. Mol. Pharmacol. 56 1 (1999) 175-184
-
(1999)
Mol. Pharmacol.
, vol.56
, Issue.1
, pp. 175-184
-
-
Rasmussen, S.G.1
Jensen, A.D.2
Liapakis, G.3
Ghanouni, P.4
Javitch, J.A.5
Gether, U.6
-
76
-
-
0037127315
-
Conformational Changes That Occur during M3 Muscarinic Acetylcholine Receptor Activation Probed by the Use of an in Situ Disulfide Cross- linking Strategy
-
Ward S.D., Hamdan F.F., Bloodworth L.M., and Wess J. Conformational Changes That Occur during M3 Muscarinic Acetylcholine Receptor Activation Probed by the Use of an in Situ Disulfide Cross- linking Strategy. J. Biol. Chem. 277 3 (2002) 2247-2257
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.3
, pp. 2247-2257
-
-
Ward, S.D.1
Hamdan, F.F.2
Bloodworth, L.M.3
Wess, J.4
-
77
-
-
31044432667
-
Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor
-
Ward S.D., Hamdan F.F., Bloodworth L.M., Siddiqui N.A., Li J.H., and Wess J. Use of an in situ disulfide cross-linking strategy to study the dynamic properties of the cytoplasmic end of transmembrane domain VI of the M3 muscarinic acetylcholine receptor. Biochemistry 45 3 (2006) 676-685
-
(2006)
Biochemistry
, vol.45
, Issue.3
, pp. 676-685
-
-
Ward, S.D.1
Hamdan, F.F.2
Bloodworth, L.M.3
Siddiqui, N.A.4
Li, J.H.5
Wess, J.6
-
78
-
-
27144522107
-
Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor
-
Han S.J., Hamdan F.F., Kim S.K., Jacobson K.A., Bloodworth L.M., Li B., and Wess J. Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor. J. Biol. Chem. 280 41 (2005) 34849-34858
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.41
, pp. 34849-34858
-
-
Han, S.J.1
Hamdan, F.F.2
Kim, S.K.3
Jacobson, K.A.4
Bloodworth, L.M.5
Li, B.6
Wess, J.7
-
79
-
-
0027716597
-
Photoactivated conformational changes in rhodopsin: a time-resolved spin label study
-
Farahbakhsh Z.T., Hideg K., and Hubbell W.L. Photoactivated conformational changes in rhodopsin: a time-resolved spin label study. Science 262 5138 (1993) 1416-1419
-
(1993)
Science
, vol.262
, Issue.5138
, pp. 1416-1419
-
-
Farahbakhsh, Z.T.1
Hideg, K.2
Hubbell, W.L.3
-
80
-
-
0029730779
-
Functional interaction of transmembrane helices 3 and 6 in rhodopsin. Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant
-
Han M., Lin S.W., Minkova M., Smith S.O., and Sakmar T.P. Functional interaction of transmembrane helices 3 and 6 in rhodopsin. Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant. J. Biol. Chem. 271 50 (1996) 32337-32342
-
(1996)
J. Biol. Chem.
, vol.271
, Issue.50
, pp. 32337-32342
-
-
Han, M.1
Lin, S.W.2
Minkova, M.3
Smith, S.O.4
Sakmar, T.P.5
-
81
-
-
0029929261
-
Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin
-
Jager S., Palczewski K., and Hofmann K.P. Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin. Biochemistry 35 9 (1996) 2901-2908
-
(1996)
Biochemistry
, vol.35
, Issue.9
, pp. 2901-2908
-
-
Jager, S.1
Palczewski, K.2
Hofmann, K.P.3
-
82
-
-
0036463901
-
Efficacy at G-protein-coupled receptors
-
Kenakin T. Efficacy at G-protein-coupled receptors. Nat. Rev., Drug Discov. 1 2 (2002) 103-110
-
(2002)
Nat. Rev., Drug Discov.
, vol.1
, Issue.2
, pp. 103-110
-
-
Kenakin, T.1
-
83
-
-
0043235844
-
Ligand-selective receptor conformations revisited: the promise and the problem
-
Kenakin T. Ligand-selective receptor conformations revisited: the promise and the problem. Trends Pharmacol. Sci. 24 7 (2003) 346-354
-
(2003)
Trends Pharmacol. Sci.
, vol.24
, Issue.7
, pp. 346-354
-
-
Kenakin, T.1
-
84
-
-
0027297275
-
Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins
-
Lefkowitz R.J., Cotecchia S., Samama P., and Costa T. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends Pharmacol. Sci. 14 8 (1993) 303-307
-
(1993)
Trends Pharmacol. Sci.
, vol.14
, Issue.8
, pp. 303-307
-
-
Lefkowitz, R.J.1
Cotecchia, S.2
Samama, P.3
Costa, T.4
-
85
-
-
0028950255
-
The two-state model of receptor activation [see comments]
-
Leff P. The two-state model of receptor activation [see comments]. Trends Pharmacol. Sci. 16 3 (1995) 89-97
-
(1995)
Trends Pharmacol. Sci.
, vol.16
, Issue.3
, pp. 89-97
-
-
Leff, P.1
-
86
-
-
0030596736
-
The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy
-
Weiss J.M., Morgan P.H., Lutz M.W., and Kenakin T.P. The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy. J. Theor. Biol. 181 4 (1996) 381-397
-
(1996)
J. Theor. Biol.
, vol.181
, Issue.4
, pp. 381-397
-
-
Weiss, J.M.1
Morgan, P.H.2
Lutz, M.W.3
Kenakin, T.P.4
-
87
-
-
0035083109
-
Inverse, protean, and ligand-selective agonism: matters of receptor conformation
-
Kenakin T. Inverse, protean, and ligand-selective agonism: matters of receptor conformation. FASEB J. 15 3 (2001) 598-611
-
(2001)
FASEB J.
, vol.15
, Issue.3
, pp. 598-611
-
-
Kenakin, T.1
-
88
-
-
0345791508
-
Sequential Binding of Agonists to the {beta}2 Adrenoceptor: kinetic evidence for intermediate conformational states
-
Swaminath G., Xiang Y., Lee T.W., Steenhuis J., Parnot C., and Kobilka B.K. Sequential Binding of Agonists to the {beta}2 Adrenoceptor: kinetic evidence for intermediate conformational states. J. Biol. Chem. 279 1 (2004) 686-691
-
(2004)
J. Biol. Chem.
, vol.279
, Issue.1
, pp. 686-691
-
-
Swaminath, G.1
Xiang, Y.2
Lee, T.W.3
Steenhuis, J.4
Parnot, C.5
Kobilka, B.K.6
-
89
-
-
20444499405
-
Probing the beta2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists
-
Swaminath G., Deupi X., Lee T.W., Zhu W., Thian F.S., Kobilka T.S., and Kobilka B. Probing the beta2 Adrenoceptor Binding Site with Catechol Reveals Differences in Binding and Activation by Agonists and Partial Agonists. J. Biol. Chem. 280 23 (2005) 22165-22171
-
(2005)
J. Biol. Chem.
, vol.280
, Issue.23
, pp. 22165-22171
-
-
Swaminath, G.1
Deupi, X.2
Lee, T.W.3
Zhu, W.4
Thian, F.S.5
Kobilka, T.S.6
Kobilka, B.7
-
90
-
-
0023815680
-
Site-directed mutagenesis of the cytoplasmic domains of the human b2-adrenergic receptor. Localization of regions involved in G protein- receptor coupling
-
O'Dowd B.F., Hnatowich M., Regan J.W., Leader W.M., Caron M.G., and Lefkowitz R.J. Site-directed mutagenesis of the cytoplasmic domains of the human b2-adrenergic receptor. Localization of regions involved in G protein- receptor coupling. J. Biol. Chem. 263 31 (1988) 15985-15992
-
(1988)
J. Biol. Chem.
, vol.263
, Issue.31
, pp. 15985-15992
-
-
O'Dowd, B.F.1
Hnatowich, M.2
Regan, J.W.3
Leader, W.M.4
Caron, M.G.5
Lefkowitz, R.J.6
-
91
-
-
0025904873
-
Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process
-
Liggett S.B., Caron M.G., Lefkowitz R.J., and Hnatowich M. Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process. J. Biol. Chem. 266 8 (1991) 4816-4821
-
(1991)
J. Biol. Chem.
, vol.266
, Issue.8
, pp. 4816-4821
-
-
Liggett, S.B.1
Caron, M.G.2
Lefkowitz, R.J.3
Hnatowich, M.4
-
92
-
-
0034632864
-
Molecular mechanism of vectorial proton translocation by bacteriorhodopsin [see comments]
-
Subramaniam S., and Henderson R. Molecular mechanism of vectorial proton translocation by bacteriorhodopsin [see comments]. Nature 406 6796 (2000) 653-657
-
(2000)
Nature
, vol.406
, Issue.6796
, pp. 653-657
-
-
Subramaniam, S.1
Henderson, R.2
-
93
-
-
0028061193
-
A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin
-
Arnis S., Fahmy K., Hofmann K.P., and Sakmar T.P. A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. J. Biol. Chem. 269 39 (1994) 23879-23881
-
(1994)
J. Biol. Chem.
, vol.269
, Issue.39
, pp. 23879-23881
-
-
Arnis, S.1
Fahmy, K.2
Hofmann, K.P.3
Sakmar, T.P.4
-
94
-
-
0028014591
-
Shaker potassium channel gating. I: transitions near the open state
-
Hoshi T., Zagotta W.N., and Aldrich R.W. Shaker potassium channel gating. I: transitions near the open state. J. Gen. Physiol. 103 2 (1994) 249-278
-
(1994)
J. Gen. Physiol.
, vol.103
, Issue.2
, pp. 249-278
-
-
Hoshi, T.1
Zagotta, W.N.2
Aldrich, R.W.3
-
95
-
-
29444444012
-
Molecular basis of inverse agonism in a G protein-coupled receptor
-
Vilardaga J.P., Steinmeyer R., Harms G.S., and Lohse M.J. Molecular basis of inverse agonism in a G protein-coupled receptor. Nat. Chem. Biol. 1 1 (2005) 25-28
-
(2005)
Nat. Chem. Biol.
, vol.1
, Issue.1
, pp. 25-28
-
-
Vilardaga, J.P.1
Steinmeyer, R.2
Harms, G.S.3
Lohse, M.J.4
-
96
-
-
20844434337
-
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells
-
Hoffmann C., Gaietta G., Bunemann M., Adams S.R., Oberdorff-Maass S., Behr B., Vilardaga J.P., Tsien R.Y., Ellisman M.H., and Lohse M.J. A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells. Nat. Methods 2 3 (2005) 171-176
-
(2005)
Nat. Methods
, vol.2
, Issue.3
, pp. 171-176
-
-
Hoffmann, C.1
Gaietta, G.2
Bunemann, M.3
Adams, S.R.4
Oberdorff-Maass, S.5
Behr, B.6
Vilardaga, J.P.7
Tsien, R.Y.8
Ellisman, M.H.9
Lohse, M.J.10
-
97
-
-
0037174606
-
Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch
-
Shi L., Liapakis G., Xu R., Guarnieri F., Ballesteros J.A., and Javitch J.A. Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch. J. Biol. Chem. 277 43 (2002) 40989-40996
-
(2002)
J. Biol. Chem.
, vol.277
, Issue.43
, pp. 40989-40996
-
-
Shi, L.1
Liapakis, G.2
Xu, R.3
Guarnieri, F.4
Ballesteros, J.A.5
Javitch, J.A.6
-
98
-
-
0037176909
-
Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence
-
Mansoor S.E., McHaourab H.S., and Farrens D.L. Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence. Biochemistry 41 8 (2002) 2475-2484
-
(2002)
Biochemistry
, vol.41
, Issue.8
, pp. 2475-2484
-
-
Mansoor, S.E.1
McHaourab, H.S.2
Farrens, D.L.3
-
99
-
-
0036783213
-
Lessons from constitutively active mutants of G protein-coupled receptors
-
Parnot C., Miserey-Lenkei S., Bardin S., Corvol P., and Clauser E. Lessons from constitutively active mutants of G protein-coupled receptors. Trends Endocrinol. Metab. 13 8 (2002) 336-343
-
(2002)
Trends Endocrinol. Metab.
, vol.13
, Issue.8
, pp. 336-343
-
-
Parnot, C.1
Miserey-Lenkei, S.2
Bardin, S.3
Corvol, P.4
Clauser, E.5
-
100
-
-
0024344941
-
Identification of two serine residues involved in agonist activation of the β-adrenergic receptor
-
Strader C., Candelore M., Hill W., Sigal I., and Dixon R. Identification of two serine residues involved in agonist activation of the β-adrenergic receptor. J. Biol. Chem. 264 (1989) 13572-13578
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 13572-13578
-
-
Strader, C.1
Candelore, M.2
Hill, W.3
Sigal, I.4
Dixon, R.5
-
101
-
-
0029838206
-
Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor
-
Wieland K., Zuurmond H.M., Krasel C., Ijzerman A.P., and Lohse M.J. Involvement of Asn-293 in stereospecific agonist recognition and in activation of the beta 2-adrenergic receptor. Proc. Natl. Acad. Sci. U. S. A. 93 17 (1996) 9276-9281
-
(1996)
Proc. Natl. Acad. Sci. U. S. A.
, vol.93
, Issue.17
, pp. 9276-9281
-
-
Wieland, K.1
Zuurmond, H.M.2
Krasel, C.3
Ijzerman, A.P.4
Lohse, M.J.5
-
102
-
-
0034529234
-
The forgotten serine. A critical role for Ser-2035.42 in ligans binding to and activation of the beta 2-adrenergic receptor
-
Liapakis G., Ballesteros J.A., Papachristou S., Chan W.C., Chen X., and Javitch J.A. The forgotten serine. A critical role for Ser-2035.42 in ligans binding to and activation of the beta 2-adrenergic receptor. J. Biol. Chem. 275 48 (2000) 37779-37788
-
(2000)
J. Biol. Chem.
, vol.275
, Issue.48
, pp. 37779-37788
-
-
Liapakis, G.1
Ballesteros, J.A.2
Papachristou, S.3
Chan, W.C.4
Chen, X.5
Javitch, J.A.6
-
103
-
-
0024426708
-
A single amino acid substitution in the beta-adrenergic receptor promotes partial agonist activity from antagonists
-
Strader C.D., Candelore M.R., Hill W.S., Dixon R.A., and Sigal I.S. A single amino acid substitution in the beta-adrenergic receptor promotes partial agonist activity from antagonists. J. Biol. Chem. 264 28 (1989) 16470-16477
-
(1989)
J. Biol. Chem.
, vol.264
, Issue.28
, pp. 16470-16477
-
-
Strader, C.D.1
Candelore, M.R.2
Hill, W.S.3
Dixon, R.A.4
Sigal, I.S.5
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