Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M3 muscarinic acetylcholine receptor

Journal of Biological Chemistry

Volumn 280, Issue 41, 2005, Pages 34849-34858

  Han, Sung Jun ^a,b   Hamdan, Fadi F ^a,c   Kim, Soo Kyung ^a   Jacobson, Kenneth A ^a   Bloodworth, Lanh M ^a   Li, Bo ^a   Wess, Jürgen ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b Institute Pasteur Korea   (South Korea)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; CONFORMATIONS; CROSSLINKING; MATHEMATICAL MODELS; MEMBRANES; MUTAGENESIS;

CONFORMATIONAL CHANGES; G PROTEIN-COUPLED RECEPTORS (GPCR); MODEL SYSTEM; MUTANTS;

PROTEINS;

ACETYLCHOLINE; ASPARAGINE; ATROPINE; CARBACHOL; CYSTEINE; DIGITONIN; DISULFIDE; G PROTEIN COUPLED RECEPTOR; LEUCINE; METHYLSCOPOLAMINE; MUSCARINIC AGENT; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; N ETHYLMALEIMIDE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISULFIDE BOND; INTRACELLULAR TRANSPORT; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN LOCALIZATION; RECEPTOR BINDING; RECEPTOR UPREGULATION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

AMINO ACID SEQUENCE; ANIMALS; ASPARAGINE; BINDING SITES; BLOTTING, WESTERN; CARBACHOL; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; CROSS-LINKING REAGENTS; CYSTEINE; DISULFIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; KINETICS; LEUCINE; LIGANDS; LUCIFERASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXYGEN; PHOSPHATIDYLINOSITOLS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, MUSCARINIC; SERINE; TRANSFECTION;

ANIMALIA;

EID: 27144522107     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M506711200     Document Type: Article

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