Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation

Journal of Biological Chemistry

Volumn 281, Issue 25, 2006, Pages 17337-17346

  Elling, Christian E ^a,b   Frimurer, Thomas M ^b   Gerlach, Lars Ole ^a,b   Jorgensen, Rasmus ^b   Holst, Birgitte ^a   Schwartz, Thue W ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b 7TM Pharma A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; CONFORMATIONS; IONS; MATHEMATICAL MODELS; MOLECULAR BIOLOGY;

ACTIVATING METAL ION; POTENTIAL TRIDENTATE; RIGID BODY MOVEMENTS; SEVEN-TRANSMEMBRANE (7TM) RECEPTORS;

PROTEINS;

ASPARTIC ACID; BETA 2 ADRENERGIC RECEPTOR; CHELATING AGENT; COPPER ION; HISTIDINE; MEMBRANE RECEPTOR; METAL ION; PROLINE; RHODOPSIN; ZINC ION;

AGONIST; ANIMAL CELL; ARTICLE; ATOM; CONFORMATION; LIGAND BINDING; METAL BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMALS; CATTLE; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COPPER; COS CELLS; METALS; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, ADRENERGIC, BETA-2; RHODOPSIN; ZINC;

EID: 33745224117     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512510200     Document Type: Article

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