메뉴 건너뛰기




Volumn 398, Issue 2, 2006, Pages 153-168

Regulatory circuits controlling white versus brown adipocyte differentiation

Author keywords

Brown adipose tissue (BAT); Peroxisome proliferator activated receptor co activator 1 (PGC 1 ); Signalling; Transcription; White adipose tissue (WAT)

Indexed keywords

BIOMEDICAL ENGINEERING; CELLS; DISEASES;

EID: 33748366392     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060402     Document Type: Review
Times cited : (144)

References (220)
  • 2
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon, B. and Nedergaard, J. (2004) Brown adipose tissue: function and physiological significance. Physiol. Rev. 84, 277-359
    • (2004) Physiol. Rev. , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 3
    • 0035488362 scopus 로고    scopus 로고
    • Does brown adipose tissue (BAT) have a role in the physiology or treatment of human obesity?
    • Himms-Hagert, J. (2001) Does brown adipose tissue (BAT) have a role in the physiology or treatment of human obesity? Rev. Endocr. Metab. Disord. 2, 395-401
    • (2001) Rev. Endocr. Metab. Disord. , vol.2 , pp. 395-401
    • Himms-Hagert, J.1
  • 4
    • 0034289797 scopus 로고    scopus 로고
    • The human uncoupling protein-1 gene (UCP1): Present status and perspectives in obesity research
    • Gonzalez-Barroso, M. D., Ricquier, D. and Cassard-Doulcier, A. M. (2000) The human uncoupling protein-1 gene (UCP1): present status and perspectives in obesity research. Obes. Rev. 1, 61-72
    • (2000) Obes. Rev. , vol.1 , pp. 61-72
    • Gonzalez-Barroso, M.D.1    Ricquier, D.2    Cassard-Doulcier, A.M.3
  • 5
    • 4544357340 scopus 로고    scopus 로고
    • Learning new tricks from old dogs: β-adrenergic receptors teach new lessons on firing up adipose tissue metabolism
    • Collins, S., Cao, W. and Robidoux, J. (2004) Learning new tricks from old dogs: β-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol. Endocrinol. 18, 2123-2131
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2123-2131
    • Collins, S.1    Cao, W.2    Robidoux, J.3
  • 6
    • 0021251537 scopus 로고
    • Energy balance following sympathetic denervation of brown adipose tissue
    • Dulloo, A. G. and Miller, D. S. (1984) Energy balance following sympathetic denervation of brown adipose tissue. Can. J. Physiol. Pharmacol. 62, 235-240
    • (1984) Can. J. Physiol. Pharmacol. , vol.62 , pp. 235-240
    • Dulloo, A.G.1    Miller, D.S.2
  • 7
    • 0030021071 scopus 로고    scopus 로고
    • Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia
    • Hamann, A., Flier, J. S. and Lowell, B. B. (1996) Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 137, 21-29
    • (1996) Endocrinology , vol.137 , pp. 21-29
    • Hamann, A.1    Flier, J.S.2    Lowell, B.B.3
  • 9
    • 0030908827 scopus 로고    scopus 로고
    • Raising at thermoneutrality prevents obesity and hyperphagia in BAT-ablated transgenic mice
    • Melnyk, A., Harper, M. E. and Himms-Hagen, J. (1997) Raising at thermoneutrality prevents obesity and hyperphagia in BAT-ablated transgenic mice. Am. J. Physiol. 41, R1088-R1093
    • (1997) Am. J. Physiol. , vol.41
    • Melnyk, A.1    Harper, M.E.2    Himms-Hagen, J.3
  • 11
    • 0030013375 scopus 로고    scopus 로고
    • Reduction of dietary obesity in aP2-Ucp transgenic mice: Physiology and adipose tissue distribution
    • Kopecky, J., Hodny, Z., Rossmeisl, M., Syrovy, I. and Kozak, L. R (1996) Reduction of dietary obesity in aP2-Ucp transgenic mice: physiology and adipose tissue distribution. Am. J. Physiol. Endocrinol. Metab. 270, E768-E775
    • (1996) Am. J. Physiol. Endocrinol. Metab. , vol.270
    • Kopecky, J.1    Hodny, Z.2    Rossmeisl, M.3    Syrovy, I.4    Kozak, L.R.5
  • 12
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky, J., Clarke, G., Enerback, S., Spiegelman, B. and Kozak, L. P. (1995) Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96, 2914-2923
    • (1995) J. Clin. Invest. , vol.96 , pp. 2914-2923
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 15
    • 17144424946 scopus 로고    scopus 로고
    • SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
    • Shi, T., Wang, F., Stieren, E. and Tong, Q. (2005) SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J. Biol. Chem. 280, 13560-13567
    • (2005) J. Biol. Chem. , vol.280 , pp. 13560-13567
    • Shi, T.1    Wang, F.2    Stieren, E.3    Tong, Q.4
  • 17
    • 0035366502 scopus 로고    scopus 로고
    • Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype
    • Moulin, K., Truel, N., Andre, M., Arnauld, E., Nibbelink, M., Cousin, B., Dani, C., Penicaud, L. and Casteilla, L. (2001) Emergence during development of the white-adipocyte cell phenotype is independent of the brown-adipocyte cell phenotype. Biochem. J. 356, 659-664
    • (2001) Biochem. J. , vol.356 , pp. 659-664
    • Moulin, K.1    Truel, N.2    Andre, M.3    Arnauld, E.4    Nibbelink, M.5    Cousin, B.6    Dani, C.7    Penicaud, L.8    Casteilla, L.9
  • 18
    • 0031105557 scopus 로고    scopus 로고
    • Functional differentiation of white and brown adipocytes
    • Klaus, S. (1997) Functional differentiation of white and brown adipocytes. BioEssays 19, 215-223
    • (1997) BioEssays , vol.19 , pp. 215-223
    • Klaus, S.1
  • 19
    • 0024785312 scopus 로고
    • Ontogenetical changes in adipose tissue of the cat: Convertible adipose tissue
    • Loncar, D. and Afzelius, B. A. (1989) Ontogenetical changes in adipose tissue of the cat: convertible adipose tissue. J. Ultrastruct. Mol. Struct. Res. 102, 9-23
    • (1989) J. Ultrastruct. Mol. Struct. Res. , vol.102 , pp. 9-23
    • Loncar, D.1    Afzelius, B.A.2
  • 20
    • 0023266408 scopus 로고
    • Immunological, histological and biochemical assessment of brown adipose tissue activity in neonatal, control and β-stimulant-treated adult dogs
    • Ashwell, M., Stirling, D., Freeman, S. and Holloway, B. R. (1987) Immunological, histological and biochemical assessment of brown adipose tissue activity in neonatal, control and β-stimulant-treated adult dogs. Int. J. Obes. 11, 357-365
    • (1987) Int. J. Obes. , vol.11 , pp. 357-365
    • Ashwell, M.1    Stirling, D.2    Freeman, S.3    Holloway, B.R.4
  • 21
    • 0027431063 scopus 로고
    • Postnatal development of uncoupling protein, uncoupling protein mRNA, and Glut4 in adipose tissues of goats
    • Trayhurn, P., Thomas, M. E. and Keith, J. S. (1993) Postnatal development of uncoupling protein, uncoupling protein mRNA, and Glut4 in adipose tissues of goats. Am. J. Physiol. 265, R676-R682
    • (1993) Am. J. Physiol. , vol.265
    • Trayhurn, P.1    Thomas, M.E.2    Keith, J.S.3
  • 22
    • 0024592001 scopus 로고
    • Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species
    • Casteilla, L., Champigny, O., Bouillaud, F., Robelin, J. and Ricquier, D. (1989) Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species. Biochem. J. 257, 665-671
    • (1989) Biochem. J. , vol.257 , pp. 665-671
    • Casteilla, L.1    Champigny, O.2    Bouillaud, F.3    Robelin, J.4    Ricquier, D.5
  • 24
    • 0022499231 scopus 로고
    • Brown adipose tissue uncoupling protein content in human infants, children and adults
    • Lean, M. E., James, W. P., Jennings, G. and Trayhurn, P. (1986) Brown adipose tissue uncoupling protein content in human infants, children and adults. Clin. Sci. 71, 291-297
    • (1986) Clin. Sci. , vol.71 , pp. 291-297
    • Lean, M.E.1    James, W.P.2    Jennings, G.3    Trayhurn, P.4
  • 25
    • 0022943269 scopus 로고
    • The effect of intermittent cold treatment on the adipose tissue of the cat: Apparent transformation from white to brown adipose tissue
    • Loncar, O., Bedrica, L., Mayer, J., Cannon, B., Nedergaard, J., Afzelius, B. A. and Svajger, A. (1986) The effect of intermittent cold treatment on the adipose tissue of the cat: apparent transformation from white to brown adipose tissue. J. Ultrastruct. Mol. Struct. Res. 97, 119-129
    • (1986) J. Ultrastruct. Mol. Struct. Res. , vol.97 , pp. 119-129
    • Loncar, O.1    Bedrica, L.2    Mayer, J.3    Cannon, B.4    Nedergaard, J.5    Afzelius, B.A.6    Svajger, A.7
  • 26
    • 0025836657 scopus 로고
    • β-3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs
    • Champigny, O., Ricguier, D., Blondel, O., Mayers, R. M., Briscoe, M. G. and Holloway, B. R. (1991) β-3-Adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs. Proc. Natl. Acad. Sci. U.S.A. 88, 10774-10777
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 10774-10777
    • Champigny, O.1    Ricguier, D.2    Blondel, O.3    Mayers, R.M.4    Briscoe, M.G.5    Holloway, B.R.6
  • 27
    • 0027669006 scopus 로고
    • The β-3-adrenoceptor agonist ICI-D7114 is not as efficient on reinduction of uncoupling protein mRNA in sheep as it is in dogs and smaller species
    • Nougues, J., Reyne, Y., Champigny, O., Holloway, B., Casteilla, L. and Ricquier, D. (1993) The β-3-adrenoceptor agonist ICI-D7114 is not as efficient on reinduction of uncoupling protein mRNA in sheep as it is in dogs and smaller species. J. Anim. Sci. 71, 2388-2394
    • (1993) J. Anim. Sci. , vol.71 , pp. 2388-2394
    • Nougues, J.1    Reyne, Y.2    Champigny, O.3    Holloway, B.4    Casteilla, L.5    Ricquier, D.6
  • 28
    • 0030717887 scopus 로고    scopus 로고
    • Uncoupling protein gene: Quantification of expression levels in adipose tissues of obese and non-obese humans
    • Oberkofler, H., Dallinger, G., Liu, Y. M., Hell, E., Krempler, F. and Patsch, W. (1997) Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans. J. Lipid Res. 38, 2125-2133
    • (1997) J. Lipid Res. , vol.38 , pp. 2125-2133
    • Oberkofler, H.1    Dallinger, G.2    Liu, Y.M.3    Hell, E.4    Krempler, F.5    Patsch, W.6
  • 31
    • 0020466632 scopus 로고
    • Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma
    • Ricquier, O., Nechad, M. and Mory, G. (1982) Ultrastructural and biochemical characterization of human brown adipose tissue in pheochromocytoma. J. Clin. Endocrinol. Metab. 54, 803-807
    • (1982) J. Clin. Endocrinol. Metab. , vol.54 , pp. 803-807
    • Ricquier, O.1    Nechad, M.2    Mory, G.3
  • 32
    • 0022482362 scopus 로고
    • Brown adipose tissue in patients with pheochromocytoma
    • Lean, M. E., James, W. P., Jennings, G. and Trayhurn, P. (1986) Brown adipose tissue in patients with pheochromocytoma. Int. J. Obes. 10, 219-227
    • (1986) Int. J. Obes. , vol.10 , pp. 219-227
    • Lean, M.E.1    James, W.P.2    Jennings, G.3    Trayhurn, P.4
  • 33
    • 0028214269 scopus 로고
    • Immunohistochemical identification of the uncoupling protein in human hibernoma
    • Zancanaro, C., Pelosi, G., Accordini, C., Balercia, G., Sbabo, L. and Cinti, S. (1994) Immunohistochemical identification of the uncoupling protein in human hibernoma. Biol. Cell 80, 75-78
    • (1994) Biol. Cell , vol.80 , pp. 75-78
    • Zancanaro, C.1    Pelosi, G.2    Accordini, C.3    Balercia, G.4    Sbabo, L.5    Cinti, S.6
  • 34
    • 0027051199 scopus 로고
    • Occurrence of brown adipocytes in rat white adipose tissue: Molecular and morphological characterization
    • Cousin, B., Cinti, S., Morroni, M., Raimbault, S., Ricquier, D., Penicaud, L. and Casteilla, L. (1992) Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J. Cell Sci. 103, 931-942
    • (1992) J. Cell Sci. , vol.103 , pp. 931-942
    • Cousin, B.1    Cinti, S.2    Morroni, M.3    Raimbault, S.4    Ricquier, D.5    Penicaud, L.6    Casteilla, L.7
  • 35
    • 0026075907 scopus 로고
    • Convertible adipose tissue in mice
    • Loncar, D. (1991) Convertible adipose tissue in mice. Cell Tissue Res. 266, 149-161
    • (1991) Cell Tissue Res. , vol.266 , pp. 149-161
    • Loncar, D.1
  • 36
    • 0032528169 scopus 로고    scopus 로고
    • Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity
    • Guerra, C., Koza, R. A., Yamashita, H., Walsh, K. and Kozak, L. P. (1998) Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102, 412-420
    • (1998) J. Clin. Invest. , vol.102 , pp. 412-420
    • Guerra, C.1    Koza, R.A.2    Yamashita, H.3    Walsh, K.4    Kozak, L.P.5
  • 38
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M. and Spiegelman, B. M. (1998) A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92, 829-839
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 43
    • 4644222981 scopus 로고    scopus 로고
    • Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) γ2 gene expression in brown adipocytes: Intracellular signalling and effects on PPARγ2 and PPARγ1 protein levels
    • Lindgren, E. M., Nielsen, R., Petrovic, N., Jacobsson, A., Mandrup, S., Cannon, B. and Nedergaard, J. (2004) Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) γ2 gene expression in brown adipocytes: intracellular signalling and effects on PPARγ2 and PPARγ1 protein levels. Biochem. J. 382, 597-606
    • (2004) Biochem. J. , vol.382 , pp. 597-606
    • Lindgren, E.M.1    Nielsen, R.2    Petrovic, N.3    Jacobsson, A.4    Mandrup, S.5    Cannon, B.6    Nedergaard, J.7
  • 44
    • 0034193336 scopus 로고    scopus 로고
    • Differential adrenergic regulation of the gene expression of the β-adrenoceptor subtypes β1, β2 and β3 in brown adipocytes
    • Bengtsson, T., Cannon, B. and Nedergaard, J. (2000) Differential adrenergic regulation of the gene expression of the β-adrenoceptor subtypes β1, β2 and β3 in brown adipocytes. Biochem. J. 347, 643-651
    • (2000) Biochem. J. , vol.347 , pp. 643-651
    • Bengtsson, T.1    Cannon, B.2    Nedergaard, J.3
  • 46
    • 0036010603 scopus 로고    scopus 로고
    • Novel adipocyte lines from brown fat: A model system for the study of differentiation, energy metabolism, and insulin action
    • Klein, J., Fasshauer, M., Klein, H. H., Benito, M. and Kahn, C. R. (2002) Novel adipocyte lines from brown fat: a model system for the study of differentiation, energy metabolism, and insulin action. BioEssays 24, 382-388
    • (2002) BioEssays , vol.24 , pp. 382-388
    • Klein, J.1    Fasshauer, M.2    Klein, H.H.3    Benito, M.4    Kahn, C.R.5
  • 48
    • 0027131838 scopus 로고
    • Establishment of permanent brown adipocyte cell lines achieved by transfection with SV40 large T antigen and ras genes
    • Benito, M., Porras, A. and Santos, E. (1993) Establishment of permanent brown adipocyte cell lines achieved by transfection with SV40 large T antigen and ras genes. Exp. Cell Res. 209, 248-254
    • (1993) Exp. Cell Res. , vol.209 , pp. 248-254
    • Benito, M.1    Porras, A.2    Santos, E.3
  • 49
    • 0027982813 scopus 로고
    • Norepinephrine-dependent selection of brown adipocyte cell lines
    • Kozak, U. C. and Kozak, L. P. (1994) Norepinephrine-dependent selection of brown adipocyte cell lines. Endocrinology 134, 906-913
    • (1994) Endocrinology , vol.134 , pp. 906-913
    • Kozak, U.C.1    Kozak, L.P.2
  • 51
    • 0033521022 scopus 로고    scopus 로고
    • β3-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes
    • Klein, J., Fasshauer, M., Ito, M., Lowell, B. B., Benito, M. and Kahn, C. R. (1999) β3-Adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J. Biol. Chem. 274, 34795-34802
    • (1999) J. Biol. Chem. , vol.274 , pp. 34795-34802
    • Klein, J.1    Fasshauer, M.2    Ito, M.3    Lowell, B.B.4    Benito, M.5    Kahn, C.R.6
  • 52
    • 0035823625 scopus 로고    scopus 로고
    • Distinct transcriptional profiles of adipogenesis in vivo and in vitro
    • Soukas, A., Socci, N. D., Saatkamp, B. D., Novelli, S. and Friedman, J. M. (2001) Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J. Biol. Chem. 276, 34167-34174
    • (2001) J. Biol. Chem. , vol.276 , pp. 34167-34174
    • Soukas, A.1    Socci, N.D.2    Saatkamp, B.D.3    Novelli, S.4    Friedman, J.M.5
  • 53
    • 0028935963 scopus 로고
    • Regulation of the uncoupling protein gene (Ucp) by β1, β2, and β3-adretiergic receptor subtypes in immortalized brown adipose cell lines
    • Rohlfs, E. M., Daniel, K. W., Premont, R. T., Kozak, L. P. and Collins, S. (1995) Regulation of the uncoupling protein gene (Ucp) by β1, β2, and β3-adretiergic receptor subtypes in immortalized brown adipose cell lines. J. Biol. Chem. 270, 10723-10732
    • (1995) J. Biol. Chem. , vol.270 , pp. 10723-10732
    • Rohlfs, E.M.1    Daniel, K.W.2    Premont, R.T.3    Kozak, L.P.4    Collins, S.5
  • 56
    • 1242308499 scopus 로고    scopus 로고
    • Comparison of gene expression profiles between white and brown adipose tissues of rat by microarray analysis
    • Unami, A., Shinohara, Y., Kajimoto, K. and Baba, Y. (2004) Comparison of gene expression profiles between white and brown adipose tissues of rat by microarray analysis. Biochem. Pharmacol. 67, 555-564
    • (2004) Biochem. Pharmacol. , vol.67 , pp. 555-564
    • Unami, A.1    Shinohara, Y.2    Kajimoto, K.3    Baba, Y.4
  • 57
    • 0025132245 scopus 로고
    • Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    • Issemann, I. and Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (London) 347, 645-650
    • (1990) Nature (London) , vol.347 , pp. 645-650
    • Issemann, I.1    Green, S.2
  • 58
    • 0020727262 scopus 로고
    • Thyroxine 5́-deiodinase activity in brown adipose tissue
    • Leonard, J. L., Meilen, S. A. and Larsen, P. R. (1983)Thyroxine 5́-deiodinase activity in brown adipose tissue. Endocrinology 112, 1153-1155
    • (1983) Endocrinology , vol.112 , pp. 1153-1155
    • Leonard, J.L.1    Meilen, S.A.2    Larsen, P.R.3
  • 62
    • 4043164343 scopus 로고    scopus 로고
    • Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells
    • Chiu, C. H., Lin, W. D., Huang, S. Y. and Lee, Y. H. (2004) Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells. Genes Dev. 16, 1970-1975
    • (2004) Genes Dev. , vol.16 , pp. 1970-1975
    • Chiu, C.H.1    Lin, W.D.2    Huang, S.Y.3    Lee, Y.H.4
  • 63
    • 0029737861 scopus 로고    scopus 로고
    • Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A
    • Cummings, D. E., Brandon, E. P., Planas, J. V., Motamed, K., Idzerda, R. L. and McKnight, G. S. (1996) Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A. Nature (London) 382, 622-626
    • (1996) Nature (London) , vol.382 , pp. 622-626
    • Cummings, D.E.1    Brandon, E.P.2    Planas, J.V.3    Motamed, K.4    Idzerda, R.L.5    McKnight, G.S.6
  • 64
    • 17944377509 scopus 로고    scopus 로고
    • FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
    • Cederberg, A., Gronning, L. M., Ahren, B., Tasken, K., Carlsson, P. and Enerbäck, S. (2001) FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106, 563-573
    • (2001) Cell , vol.106 , pp. 563-573
    • Cederberg, A.1    Gronning, L.M.2    Ahren, B.3    Tasken, K.4    Carlsson, P.5    Enerbäck, S.6
  • 65
    • 0345420481 scopus 로고    scopus 로고
    • Insulin and TNFα induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK1/2-dependent pathways
    • Gronning, L. M., Cederberg, A., Miura, N., Enerbäck, S. and Tasken, K. (2002) Insulin and TNFα induce expression of the forkhead transcription factor gene Foxc2 in 3T3-L1 adipocytes via PI3K and ERK1/2-dependent pathways. Mol. Endocrinol. 16, 873-883
    • (2002) Mol. Endocrinol. , vol.16 , pp. 873-883
    • Gronning, L.M.1    Cederberg, A.2    Miura, N.3    Enerbäck, S.4    Tasken, K.5
  • 67
    • 5644278855 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxC2 inhibits white adipocyte differentiation
    • Davis, K. E., Moldes, M. and Farmer, S. R. (2004) The forkhead transcription factor FoxC2 inhibits white adipocyte differentiation. J. Biol. Chem. 279, 42453-42461
    • (2004) J. Biol. Chem. , vol.279 , pp. 42453-42461
    • Davis, K.E.1    Moldes, M.2    Farmer, S.R.3
  • 69
    • 1542373685 scopus 로고    scopus 로고
    • Transcriptional regulatory circuits controlling mitochondrial biogenesis and function
    • Kelly, D. P. and Scarpulla, R. C. (2004) Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev. 18, 357-368
    • (2004) Genes Dev. , vol.18 , pp. 357-368
    • Kelly, D.P.1    Scarpulla, R.C.2
  • 72
    • 33646124709 scopus 로고    scopus 로고
    • Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation
    • Uldry, M., Yang, W., St-Pierre, J., Lin, J., Seale, P. and Spiegelman, B. M. (2006) Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 3, 333-341
    • (2006) Cell Metab. , vol.3 , pp. 333-341
    • Uldry, M.1    Yang, W.2    St-Pierre, J.3    Lin, J.4    Seale, P.5    Spiegelman, B.M.6
  • 74
    • 0038810035 scopus 로고    scopus 로고
    • An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle
    • Handschin, C., Rhee, J., Lin, J., Tarr, P. T. and Spiegelman, B. M. (2003) An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proc. Natl. Acad. Sci. U.S.A. 100, 7111-7116
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 7111-7116
    • Handschin, C.1    Rhee, J.2    Lin, J.3    Tarr, P.T.4    Spiegelman, B.M.5
  • 77
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin, J., Handschin, C. and Spiegelman, B. M. (2005) Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1, 361-370
    • (2005) Cell Metab. , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 79
    • 1642293248 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene
    • Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M. and Collins, S. (2004) p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Mol. Cell. Biol. 24, 3057-3067
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 3057-3067
    • Cao, W.1    Daniel, K.W.2    Robidoux, J.3    Puigserver, P.4    Medvedev, A.V.5    Bai, X.6    Floering, L.M.7    Spiegelman, B.M.8    Collins, S.9
  • 80
    • 0035920122 scopus 로고    scopus 로고
    • β-adrenergic activation of p38 MAP kinase in adipocytes
    • Cao, W., Medvedev, A. V., Daniel, K. W. and Collins, S. (2001) β-Adrenergic activation of p38 MAP kinase in adipocytes. J. Biol. Chem. 276, 27077-27082
    • (2001) J. Biol. Chem. , vol.276 , pp. 27077-27082
    • Cao, W.1    Medvedev, A.V.2    Daniel, K.W.3    Collins, S.4
  • 83
    • 0035859836 scopus 로고    scopus 로고
    • Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor
    • Knutti, D., Kressler, D. and Kralli, A. (2001) Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc. Natl. Acad. Sci. U.S.A. 98, 9713-9718
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 9713-9718
    • Knutti, D.1    Kressler, D.2    Kralli, A.3
  • 84
    • 0037185003 scopus 로고    scopus 로고
    • Identification of a specific molecular repressor of the peroxisome proliferator-activated receptorycoactivator-1α (PGC-1α)
    • Ichida, M., Nemoto, S. and Finkel, T. (2002) Identification of a specific molecular repressor of the peroxisome proliferator-activated receptorycoactivator-1α (PGC-1α). J. Biol. Chem. 277, 50991-50995
    • (2002) J. Biol. Chem. , vol.277 , pp. 50991-50995
    • Ichida, M.1    Nemoto, S.2    Finkel, T.3
  • 85
    • 22344440666 scopus 로고    scopus 로고
    • Activation of nuclear receptor coactivator PGC-1α by arginine methylation
    • Teyssier, C., Ma, H., Emter, R., Kralli, A. and Stallcup, M. R. (2005) Activation of nuclear receptor coactivator PGC-1α by arginine methylation. Genes Dev. 19, 1466-1473
    • (2005) Genes Dev. , vol.19 , pp. 1466-1473
    • Teyssier, C.1    Ma, H.2    Emter, R.3    Kralli, A.4    Stallcup, M.R.5
  • 86
    • 18144411313 scopus 로고    scopus 로고
    • SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α
    • Nemoto, S., Ferguson, M. M. and Finkel, T. (2005) SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1α. J. Biol. Chem. 280, 16456-16460
    • (2005) J. Biol. Chem. , vol.280 , pp. 16456-16460
    • Nemoto, S.1    Ferguson, M.M.2    Finkel, T.3
  • 88
    • 0037127204 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), a novel PGC-1-related transcription coactivator associated with host cell factor
    • Lin, J., Puigserver, P., Donovan, J., Tarr, P. and Spiegelman, B. M. (2002) Peroxisome proliferator-activated receptor γ coactivator 1β (PGC-1β), a novel PGC-1-related transcription coactivator associated with host cell factor. J. Biol. Chem. 277, 1645-1648
    • (2002) J. Biol. Chem. , vol.277 , pp. 1645-1648
    • Lin, J.1    Puigserver, P.2    Donovan, J.3    Tarr, P.4    Spiegelman, B.M.5
  • 89
    • 0037134493 scopus 로고    scopus 로고
    • The PGC-1-related protein PERC is a selective coactivator of estrogen receptor α
    • Kressler, D., Schreiber, S. N., Knutti, D. and Kralli, A. (2002) The PGC-1-related protein PERC is a selective coactivator of estrogen receptor α. J. Biol. Chem. 277, 13918-13925
    • (2002) J. Biol. Chem. , vol.277 , pp. 13918-13925
    • Kressler, D.1    Schreiber, S.N.2    Knutti, D.3    Kralli, A.4
  • 90
    • 0035016566 scopus 로고    scopus 로고
    • PGC-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells
    • Andersson, U. and Scarpulla, R. C. (2001) PGC-1-related coactivator, a novel, serum-inducible coactivator of nuclear respiratory factor 1-dependent transcription in mammalian cells. Mol. Cell. Biol. 21, 3738-3749
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3738-3749
    • Andersson, U.1    Scarpulla, R.C.2
  • 91
    • 0038036024 scopus 로고    scopus 로고
    • Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells
    • St-Pierre, J., Lin, J., Krauss, S., Tarr, P. T., Yang, R., Newgard, C. B. and Spiegelman, B. M. (2003) Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells. J. Biol. Chem. 278, 26597-26603
    • (2003) J. Biol. Chem. , vol.278 , pp. 26597-26603
    • St.-Pierre, J.1    Lin, J.2    Krauss, S.3    Tarr, P.T.4    Yang, R.5    Newgard, C.B.6    Spiegelman, B.M.7
  • 92
    • 0038682372 scopus 로고    scopus 로고
    • Characterization of the human, mouse and rat PGC1β (peroxisome-proliferator-activated receptor-γ co-activator 1β) gene in vitro and in vivo
    • Meirhaeghe, A., Crowley, V., Lenaghan, C., Lelliott, C., Green, K., Stewart, A., Hart, K., Schinner, S., Sethi, J. K., Yeo, G. et al. (2003) Characterization of the human, mouse and rat PGC1β (peroxisome- proliferator-activated receptor-γ co-activator 1β) gene in vitro and in vivo. Biochem. J. 373, 155-165
    • (2003) Biochem. J. , vol.373 , pp. 155-165
    • Meirhaeghe, A.1    Crowley, V.2    Lenaghan, C.3    Lelliott, C.4    Green, K.5    Stewart, A.6    Hart, K.7    Schinner, S.8    Sethi, J.K.9    Yeo, G.10
  • 95
    • 13444306450 scopus 로고    scopus 로고
    • Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators
    • Gleyzer, N., Vercauteren, K. and Scarpulla, R. C. (2005) Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Mol. Cell. Biol. 25, 1354-1366
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 1354-1366
    • Gleyzer, N.1    Vercauteren, K.2    Scarpulla, R.C.3
  • 98
    • 10344261553 scopus 로고    scopus 로고
    • cAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1
    • Hoang, T., Fenne, I. S., Cook, C., Borud, B., Bakke, M., Lien, E. A. and Mellgren, G. (2004) cAMP-dependent protein kinase regulates ubiquitin- proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. J. Biol. Chem. 279, 49120-49130
    • (2004) J. Biol. Chem. , vol.279 , pp. 49120-49130
    • Hoang, T.1    Fenne, I.S.2    Cook, C.3    Borud, B.4    Bakke, M.5    Lien, E.A.6    Mellgren, G.7
  • 100
    • 0029121358 scopus 로고
    • Nuclear factor Rip140 modulates transcriptional activation by the estrogen-receptor
    • Cavailles, V., Dauvois, S., L'Horset, F., Lopez, G., Hoare, S., Kushner, P. J. and Parker, M. G. (1995) Nuclear factor Rip140 modulates transcriptional activation by the estrogen-receptor. EMBO J. 14, 3741-3751
    • (1995) EMBO J. , vol.14 , pp. 3741-3751
    • Cavailles, V.1    Dauvois, S.2    L'Horset, F.3    Lopez, G.4    Hoare, S.5    Kushner, P.J.6    Parker, M.G.7
  • 101
    • 0029850086 scopus 로고    scopus 로고
    • RIP-140 interacts with multiple nuclear receptors by means of two distinct sites
    • L'Horset, F., Dauvois, S., Heery, D. M., Cavailles, V. and Parker, M. G. (1996) RIP-140 interacts with multiple nuclear receptors by means of two distinct sites. Mol. Cell. Biol. 16, 6029-6036
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 6029-6036
    • L'Horset, F.1    Dauvois, S.2    Heery, D.M.3    Cavailles, V.4    Parker, M.G.5
  • 103
    • 17844387149 scopus 로고    scopus 로고
    • Role of the RIP140 corepressor in ovulation and adipose biology
    • Steel, J. H., White, R. and Parker, M. G. (2005) Role of the RIP140 corepressor in ovulation and adipose biology. J. Endocrinol. 185, 1-9
    • (2005) J. Endocrinol. , vol.185 , pp. 1-9
    • Steel, J.H.1    White, R.2    Parker, M.G.3
  • 104
    • 0034537599 scopus 로고    scopus 로고
    • The nuclear receptor co-repressor Nrip1 (RIP140) is essential for female fertility
    • White, R., Leonardsson, G., Rosewell, I., Ann Jacobs, M., Milligan, S. and Parker, M. (2000) The nuclear receptor co-repressor Nrip1 (RIP140) is essential for female fertility. Nat. Med. 6, 1368-1374
    • (2000) Nat. Med. , vol.6 , pp. 1368-1374
    • White, R.1    Leonardsson, G.2    Rosewell, I.3    Ann Jacobs, M.4    Milligan, S.5    Parker, M.6
  • 107
    • 0028177940 scopus 로고
    • Characterization of the novel brown adipocyte cell line HIB 1B. Adrenergic pathways involved in regulation of uncoupling protein gene expression
    • Klaus, S., Choy, L., Champigny, O, Cassard-Doulcier, A. M., Ross, S., Spiegelman, B. and Ricquier, D. (1994) Characterization of the novel brown adipocyte cell line HIB 1B. Adrenergic pathways involved in regulation of uncoupling protein gene expression. J. Cell Sci. 107, 313-319
    • (1994) J. Cell Sci. , vol.107 , pp. 313-319
    • Klaus, S.1    Choy, L.2    Champigny, O.3    Cassard-Doulcier, A.M.4    Ross, S.5    Spiegelman, B.6    Ricquier, D.7
  • 108
    • 33645873573 scopus 로고    scopus 로고
    • Thermogenic mechanisms and their hormonal regulation
    • Silva, J. E. (2006) Thermogenic mechanisms and their hormonal regulation. Physiol. Rev. 86, 435-464
    • (2006) Physiol. Rev. , vol.86 , pp. 435-464
    • Silva, J.E.1
  • 110
    • 24344476219 scopus 로고    scopus 로고
    • Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots
    • Xue, B. Z., Coulter, A., Rim, J. S., Koza, R. A. and Kozak, L. P. (2005) Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol. Cell. Biol. 25, 8311-8322
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 8311-8322
    • Xue, B.Z.1    Coulter, A.2    Rim, J.S.3    Koza, R.A.4    Kozak, L.P.5
  • 111
    • 0842334467 scopus 로고    scopus 로고
    • Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors
    • Golozoubova, V., Gullberg, H., Matthias, A., Cannon, B., Vennstrom, B, and Nedergaard, J. (2004) Depressed thermogenesis but competent brown adipose tissue recruitment in mice devoid of all hormone-binding thyroid hormone receptors. Mol. Endocrinol. 18, 384-401
    • (2004) Mol. Endocrinol. , vol.18 , pp. 384-401
    • Golozoubova, V.1    Gullberg, H.2    Matthias, A.3    Cannon, B.4    Vennstrom, B.5    Nedergaard, J.6
  • 113
    • 0033830783 scopus 로고    scopus 로고
    • Transcriptional control of adipogenesis
    • Rangwala, S. M. and Lazar, M. A. (2000) Transcriptional control of adipogenesis. Annu. Rev. Nutr. 20, 535-559
    • (2000) Annu. Rev. Nutr. , vol.20 , pp. 535-559
    • Rangwala, S.M.1    Lazar, M.A.2
  • 117
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
    • He, W., Barak, Y., Hevener, A., Olson, P., Liao, D., Le, J., Nelson, M., Ong, E., Olefsky, J. M. and Evans, R. M. (2003) Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle. Proc. Natl. Acad. Sci. U.S.A. 100, 15712-15717
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3    Olson, P.4    Liao, D.5    Le, J.6    Nelson, M.7    Ong, E.8    Olefsky, J.M.9    Evans, R.M.10
  • 121
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ
    • Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M. and Kliewer, S. A. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ. J. Biol. Chem. 270, 12953-12956
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 123
    • 0037414826 scopus 로고    scopus 로고
    • Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes
    • Teruel, T., Hernandez, R., Benito, M. and Lorenzo, M. (2003) Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes. J. Biol. Chem. 278, 263-269
    • (2003) J. Biol. Chem. , vol.278 , pp. 263-269
    • Teruel, T.1    Hernandez, R.2    Benito, M.3    Lorenzo, M.4
  • 124
    • 0030582447 scopus 로고    scopus 로고
    • Induction of uncoupling protein in brown adipose tissue: Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent
    • Foellmi-Adams, L. A., Wyse, B. M., Herron, D., Nedergaard, J. and Kletzien, R. F. (1996) Induction of uncoupling protein in brown adipose tissue: synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent. Biochem. Pharmacol. 52, 693-701
    • (1996) Biochem. Pharmacol. , vol.52 , pp. 693-701
    • Foellmi-Adams, L.A.1    Wyse, B.M.2    Herron, D.3    Nedergaard, J.4    Kletzien, R.F.5
  • 125
  • 126
    • 3843083938 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice
    • Sell, H., Berger, J. P., Samson, P., Castriota, G., Lalonde, J., Deshaies, Y. and Richard, D. (2004) Peroxisome proliferator-activated receptor γ agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice. Endocrinology 145, 3925-3934
    • (2004) Endocrinology , vol.145 , pp. 3925-3934
    • Sell, H.1    Berger, J.P.2    Samson, P.3    Castriota, G.4    Lalonde, J.5    Deshaies, Y.6    Richard, D.7
  • 127
    • 0034085884 scopus 로고    scopus 로고
    • A new thiazolidinedione, NC-2100, which is a weak PPARγ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice
    • Fukui, Y., Masui, S., Osada, S., Umesono, K. and Motojima, K. (2000) A new thiazolidinedione, NC-2100, which is a weak PPARγ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes 49, 759-767
    • (2000) Diabetes , vol.49 , pp. 759-767
    • Fukui, Y.1    Masui, S.2    Osada, S.3    Umesono, K.4    Motojima, K.5
  • 129
    • 0037304599 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone
    • Wilson-Fritch, L., Burkart, A., Bell, G., Mendelson, K., Leszyk, J., Nicoloro, S., Czech, M. and Corvera, S. (2003) Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone. Mol. Cell. Biol. 23, 1085-1094
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1085-1094
    • Wilson-Fritch, L.1    Burkart, A.2    Bell, G.3    Mendelson, K.4    Leszyk, J.5    Nicoloro, S.6    Czech, M.7    Corvera, S.8
  • 130
    • 13844262924 scopus 로고    scopus 로고
    • Corepressors selectively control the transcriptional activity of PPARγ in adipocytes
    • Guan, H. P., Ishizuka, T., Chui, P. C., Lehrke, M. and Lazar, M. A. (2005) Corepressors selectively control the transcriptional activity of PPARγ in adipocytes. Genes Dev. 19, 453-461
    • (2005) Genes Dev. , vol.19 , pp. 453-461
    • Guan, H.P.1    Ishizuka, T.2    Chui, P.C.3    Lehrke, M.4    Lazar, M.A.5
  • 131
    • 33646782581 scopus 로고    scopus 로고
    • Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor coactivator (PGC)-1α gene transcription: An autoregulatory loop controls PGC-1α expression in adipocytes via peroxisome proliferator-activated receptor γ coactivation
    • Hondares, E., Mora, O., Yubero, P., de la Concepcion, M. R., Iglesias, R., Giralt, M. and Villarroya, F. (2006) Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor coactivator (PGC)-1α gene transcription: an autoregulatory loop controls PGC-1α expression in adipocytes via peroxisome proliferator-activated receptor γ coactivation. Endocrinology 147, 2829-2838
    • (2006) Endocrinology , vol.147 , pp. 2829-2838
    • Hondares, E.1    Mora, O.2    Yubero, P.3    De La Concepcion, M.R.4    Iglesias, R.5    Giralt, M.6    Villarroya, F.7
  • 132
    • 1442351143 scopus 로고    scopus 로고
    • Coregulator function: A key to understanding tissue specificity of selective receptor modulators
    • Smith, C. L. and O'Malley, B. W. (2004) Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr. Rev. 25, 45-71
    • (2004) Endocr. Rev. , vol.25 , pp. 45-71
    • Smith, C.L.1    O'Malley, B.W.2
  • 134
    • 0036843143 scopus 로고    scopus 로고
    • A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity
    • Rieusset, J., Touri, F., Michalik, L., Escher, P., Desvergne, B., Niesor, E. and Wahli, W. (2002) A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity. Mol. Endocrinol. 16, 2628-2644
    • (2002) Mol. Endocrinol. , vol.16 , pp. 2628-2644
    • Rieusset, J.1    Touri, F.2    Michalik, L.3    Escher, P.4    Desvergne, B.5    Niesor, E.6    Wahli, W.7
  • 137
    • 0033595591 scopus 로고    scopus 로고
    • PPARα activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARγ-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes
    • Teruel, T., Clapham, J. C. and Smith, S. A. (1999) PPARα activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARγ-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes. Biochem. Biophys. Res. Commun. 264, 311-315
    • (1999) Biochem. Biophys. Res. Commun. , vol.264 , pp. 311-315
    • Teruel, T.1    Clapham, J.C.2    Smith, S.A.3
  • 138
    • 0035847001 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
    • Barbera, M. J., Schluter, A., Pedraza, N., Iglesias, R., Villarroya, F. and Giralt, M. (2001) Peroxisome proliferator-activated receptor α activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J. Biol. Chem. 276, 1486-1493
    • (2001) J. Biol. Chem. , vol.276 , pp. 1486-1493
    • Barbera, M.J.1    Schluter, A.2    Pedraza, N.3    Iglesias, R.4    Villarroya, F.5    Giralt, M.6
  • 139
    • 0037053326 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) γ coactivator-1 recruitment regulates PPAR subtype specificity
    • Oberkofler, H., Esterbauer, H., Linnemayr, V., Strosberg, A. D., Krempler, F. and Patsch, W. (2002) Peroxisome proliferator-activated receptor (PPAR) γ coactivator-1 recruitment regulates PPAR subtype specificity. J. Biol. Chem. 277, 16750-16757
    • (2002) J. Biol. Chem. , vol.277 , pp. 16750-16757
    • Oberkofler, H.1    Esterbauer, H.2    Linnemayr, V.3    Strosberg, A.D.4    Krempler, F.5    Patsch, W.6
  • 141
    • 0033880572 scopus 로고    scopus 로고
    • Synergistic activation of UCP-3 expression in cultured fetal rat brown adipocytes by PPARα and PPARγ ligands
    • Teruel, T., Smith, S. A., Peterson, J. and Clapham, J. C. (2000) Synergistic activation of UCP-3 expression in cultured fetal rat brown adipocytes by PPARα and PPARγ ligands. Biochem. Biophys. Res. Commun. 273, 560-564
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 560-564
    • Teruel, T.1    Smith, S.A.2    Peterson, J.3    Clapham, J.C.4
  • 142
    • 11444254011 scopus 로고    scopus 로고
    • Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor α during fasting and cold exposure in acyl-CoA detiydrogenase-deficient mice
    • Goetzman, E. S., Tian, L. and Wood, P. A. (2005) Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor α during fasting and cold exposure in acyl-CoA detiydrogenase-deficient mice. Mol. Genet. Metab. 84, 39-47
    • (2005) Mol. Genet. Metab. , vol.84 , pp. 39-47
    • Goetzman, E.S.1    Tian, L.2    Wood, P.A.3
  • 148
    • 0034663467 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ mediates the effects of long-chain fatty acids on post-confluent cell proliferation
    • Jehl-Pietri, C., Bastie, C., Gillot, I., Luquet, S. and Grimaldi, P. A. (2000) Peroxisome-proliferator-activated receptor δ mediates the effects of long-chain fatty acids on post-confluent cell proliferation. Biochem. J. 350, 93-98
    • (2000) Biochem. J. , vol.350 , pp. 93-98
    • Jehl-Pietri, C.1    Bastie, C.2    Gillot, I.3    Luquet, S.4    Grimaldi, P.A.5
  • 149
    • 0035793577 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor δ (PPARδ)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling
    • Hansen, J. B., Zhang, H., Rasmussen, T. H., Petersen, R. K., Flindt, E. N. and Kristiansen, K. (2001) Peroxisome proliferator-activated receptor δ (PPARδ)-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling. J. Biol. Chem. 276, 3175-3182
    • (2001) J. Biol. Chem. , vol.276 , pp. 3175-3182
    • Hansen, J.B.1    Zhang, H.2    Rasmussen, T.H.3    Petersen, R.K.4    Flindt, E.N.5    Kristiansen, K.6
  • 150
    • 0033618281 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor PPARδ promotes induction of PPARγ and adipocyte differentiation in 3T3C2 fibroblasts
    • Bastie, C., Holst, D., Gaillard, D., Jehl-Pietri, C. and Grimaldi, P. A. (1999) Expression of peroxisome proliferator-activated receptor PPARδ promotes induction of PPARγ and adipocyte differentiation in 3T3C2 fibroblasts. J. Biol. Chem. 274, 21920-21925
    • (1999) J. Biol. Chem. , vol.274 , pp. 21920-21925
    • Bastie, C.1    Holst, D.2    Gaillard, D.3    Jehl-Pietri, C.4    Grimaldi, P.A.5
  • 151
    • 0034624046 scopus 로고    scopus 로고
    • Alterations of peroxisome proliferator-activated receptor δ activity affect fatty acid-controlled adipose differentiation
    • Bastie, C., Luquet, S., Holst, D., Jehl-Pietri, C. and Grimaldi, P. A. (2000) Alterations of peroxisome proliferator-activated receptor δ activity affect fatty acid-controlled adipose differentiation. J. Biol. Chem. 275, 38768-38773
    • (2000) J. Biol. Chem. , vol.275 , pp. 38768-38773
    • Bastie, C.1    Luquet, S.2    Holst, D.3    Jehl-Pietri, C.4    Grimaldi, P.A.5
  • 152
    • 9444288103 scopus 로고    scopus 로고
    • PPARβ/δ potentiates PPARγ-stimulated adipocyte differentiation
    • Matsusue, K., Peters, J. M. and Gonzalez, F. J. (2004) PPARβ/δ potentiates PPARγ-stimulated adipocyte differentiation. FASEB J. 18, 1477-1479
    • (2004) FASEB J. , vol.18 , pp. 1477-1479
    • Matsusue, K.1    Peters, J.M.2    Gonzalez, F.J.3
  • 153
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor & activates fat metabolism to prevent obesity
    • Wang, Y. X., Lee, C. H., Tiep, S., Yu, R. T., Ham, J., Kang, H. and Evans, R. M. (2003) Peroxisome-proliferator-activated receptor & activates fat metabolism to prevent obesity. Cell 113, 159-170
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3    Yu, R.T.4    Ham, J.5    Kang, H.6    Evans, R.M.7
  • 155
    • 10044223533 scopus 로고    scopus 로고
    • PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis
    • Li, A. C. and Glass, C. K. (2004) PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. J. Lipid Res. 45, 2161-2173
    • (2004) J. Lipid Res. , vol.45 , pp. 2161-2173
    • Li, A.C.1    Glass, C.K.2
  • 156
    • 0036318980 scopus 로고    scopus 로고
    • Microarray analyses during adipogenesis: Understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor α in adipocyte metabolism
    • Ross, S. E., Erickson, R. L., Gerin, I., DeRose, P. M., Bajnok, L., Longo, K. A., Misek, D. E., Kuick, R., Hanash, S. M., Atkins, K. B. et al. (2002) Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor α in adipocyte metabolism. Mol. Cell. Biol. 22, 5989-5999
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5989-5999
    • Ross, S.E.1    Erickson, R.L.2    Gerin, I.3    DeRose, P.M.4    Bajnok, L.5    Longo, K.A.6    Misek, D.E.7    Kuick, R.8    Hanash, S.M.9    Atkins, K.B.10
  • 158
    • 0013199471 scopus 로고    scopus 로고
    • Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα
    • Peet, D. J., Turley, S. D., Ma, W. Z., Janowski, B. A., Lobaccaro, J. M., Hammer, R. E. and Mangelsdorf, D. J. (1998) Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRα. Cell 93, 693-704
    • (1998) Cell , vol.93 , pp. 693-704
    • Peet, D.J.1    Turley, S.D.2    Ma, W.Z.3    Janowski, B.A.4    Lobaccaro, J.M.5    Hammer, R.E.6    Mangelsdorf, D.J.7
  • 159
    • 1642465503 scopus 로고    scopus 로고
    • Liver X receptors are regulators of adipocyte gene expression but not differentiation: Identification of apoD as a direct target
    • Hummasti, S., Laffitte, B. A., Watson, M. A., Galardi, C., Chao, L. C., Ramamurthy, L., Moore, J. T. and Tontonoz, P. (2004) Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target. J. Lipid Res. 45, 616-625
    • (2004) J. Lipid Res. , vol.45 , pp. 616-625
    • Hummasti, S.1    Laffitte, B.A.2    Watson, M.A.3    Galardi, C.4    Chao, L.C.5    Ramamurthy, L.6    Moore, J.T.7    Tontonoz, P.8
  • 160
    • 11144356074 scopus 로고    scopus 로고
    • Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor γ expression
    • Seo, J. B., Moon, H. M., Kim, W. S., Lee, Y. S., Jeong, H. W., Yoo, E. J., Ham, J., Kang, H., Park, M. G., Steffensen, K. R. et al. (2004) Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor γ expression. Mol. Cell. Biol. 24, 3430-3444
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 3430-3444
    • Seo, J.B.1    Moon, H.M.2    Kim, W.S.3    Lee, Y.S.4    Jeong, H.W.5    Yoo, E.J.6    Ham, J.7    Kang, H.8    Park, M.G.9    Steffensen, K.R.10
  • 163
    • 0348111308 scopus 로고    scopus 로고
    • Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor α
    • Dalen, K. T., Ulven, S. M., Bamberg, K., Gustafsson, J. A. and Nebb, H. I. (2003) Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor α. J. Biol. Chem. 278, 48283-48291
    • (2003) J. Biol. Chem. , vol.278 , pp. 48283-48291
    • Dalen, K.T.1    Ulven, S.M.2    Bamberg, K.3    Gustafsson, J.A.4    Nebb, H.I.5
  • 164
    • 19344376244 scopus 로고    scopus 로고
    • Tissue-specific autoregulation of the LXRα gene facilitates induction of apoE in mouse adipose tissue
    • Ulven, S. M., Dalen, K. T., Gustafsson, J. A. and Nebb, H. I. (2004) Tissue-specific autoregulation of the LXRα gene facilitates induction of apoE in mouse adipose tissue. J. Lipid Res. 45, 2052-2062
    • (2004) J. Lipid Res. , vol.45 , pp. 2052-2062
    • Ulven, S.M.1    Dalen, K.T.2    Gustafsson, J.A.3    Nebb, H.I.4
  • 168
    • 27844509037 scopus 로고    scopus 로고
    • Transcriptional corepression by SHP: Molecular mechanisms and physiological consequences
    • Bavner, A., Sanyal, S., Gustafsson, J. A. and Treuter, E. (2005) Transcriptional corepression by SHP: molecular mechanisms and physiological consequences. Trends Endocrinol. Metab. 16, 478-488
    • (2005) Trends Endocrinol. Metab. , vol.16 , pp. 478-488
    • Bavner, A.1    Sanyal, S.2    Gustafsson, J.A.3    Treuter, E.4
  • 169
    • 27844551588 scopus 로고    scopus 로고
    • The orphan nuclear receptor SHP regulates PGC-1α expression and energy production in brown adipocytes
    • Wang, L., Liu, J., Saha, P., Huang, J., Chan, L., Spiegelman, B. and Moore, D. D. (2005) The orphan nuclear receptor SHP regulates PGC-1α expression and energy production in brown adipocytes. Cell Metab. 2, 227-238
    • (2005) Cell Metab. , vol.2 , pp. 227-238
    • Wang, L.1    Liu, J.2    Saha, P.3    Huang, J.4    Chan, L.5    Spiegelman, B.6    Moore, D.D.7
  • 170
    • 0032515065 scopus 로고    scopus 로고
    • The role of C/EBP genes in adipocyte differentiation
    • Darlington, G. J., Ross, S. E. and MacDougald, O. A. (1998) The role of C/EBP genes in adipocyte differentiation. J. Biol. Chem. 273, 30057-30060
    • (1998) J. Biol. Chem. , vol.273 , pp. 30057-30060
    • Darlington, G.J.1    Ross, S.E.2    MacDougald, O.A.3
  • 172
    • 0031435337 scopus 로고    scopus 로고
    • Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene
    • Tanaka, T., Yoshida, N., Kishimoto, T. and Akira, S. (1997) Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene. EMBO J. 16, 7432-7443
    • (1997) EMBO J. , vol.16 , pp. 7432-7443
    • Tanaka, T.1    Yoshida, N.2    Kishimoto, T.3    Akira, S.4
  • 174
    • 0029746172 scopus 로고    scopus 로고
    • Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein a
    • Flodby, P., Barlow, C., Kylefjord, H., Ahrlund-Richter, L. and Xanthopoulos, K. G. (1996) Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein a. J. Biol. Chem. 271, 24753-24760
    • (1996) J. Biol. Chem. , vol.271 , pp. 24753-24760
    • Flodby, P.1    Barlow, C.2    Kylefjord, H.3    Ahrlund-Richter, L.4    Xanthopoulos, K.G.5
  • 175
    • 0037077240 scopus 로고    scopus 로고
    • Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein α
    • Carmona, M. C., Iglesias, R., Obregon, M. J., Darlington, G. J., Villarroya, F. and Giralt, M. (2002) Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein α. J. Biol. Chem. 277, 21489-21498
    • (2002) J. Biol. Chem. , vol.277 , pp. 21489-21498
    • Carmona, M.C.1    Iglesias, R.2    Obregon, M.J.3    Darlington, G.J.4    Villarroya, F.5    Giralt, M.6
  • 178
    • 0035913913 scopus 로고    scopus 로고
    • E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo
    • Porse, B. T., Pedersen, T. A., Xu, X., Lindberg, B., Wewer, U. M., Friis-Hansen, L. and Nerlov, C. (2001) E2F repression by C/EBPα is required for adipogenesis and granulopoiesis in vivo. Cell 107, 247-258
    • (2001) Cell , vol.107 , pp. 247-258
    • Porse, B.T.1    Pedersen, T.A.2    Xu, X.3    Lindberg, B.4    Wewer, U.M.5    Friis-Hansen, L.6    Nerlov, C.7
  • 179
    • 0033624628 scopus 로고    scopus 로고
    • C/EBPβ, when expressed from the C/EBPα gene locus, can functionally replace C/EBPα in liver but not in adipose tissue
    • Chen, S. S., Chen, J. F., Johnson, P. F., Muppala, V. and Lee, Y. H. (2000) C/EBPβ, when expressed from the C/EBPα gene locus, can functionally replace C/EBPα in liver but not in adipose tissue. Mol. Cell. Biol. 20, 7292-7299
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 7292-7299
    • Chen, S.S.1    Chen, J.F.2    Johnson, P.F.3    Muppala, V.4    Lee, Y.H.5
  • 180
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White, M. F. (2002) IRS proteins and the common path to diabetes. Am. J. Physiol. Endocrinol. Metab. 283, E413-E422
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.283
    • White, M.F.1
  • 182
    • 1342282912 scopus 로고    scopus 로고
    • Differential roles of insulin receptor substrates in brown adipocyte differentiation
    • Tseng, Y. H., Kriauciunas, K. M., Kokkotou, E. and Kahn, C. R. (2004) Differential roles of insulin receptor substrates in brown adipocyte differentiation. Mol. Cell. Biol. 24, 1918-1929
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 1918-1929
    • Tseng, Y.H.1    Kriauciunas, K.M.2    Kokkotou, E.3    Kahn, C.R.4
  • 184
    • 0032538890 scopus 로고    scopus 로고
    • Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase
    • Shima, H., Pende, M., Chen, Y., Fumagalli, S., Thomas, G. and Kozma, S. C. (1998) Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17, 6649-6659
    • (1998) EMBO J. , vol.17 , pp. 6649-6659
    • Shima, H.1    Pende, M.2    Chen, Y.3    Fumagalli, S.4    Thomas, G.5    Kozma, S.C.6
  • 186
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar, D. C. and Blenis, J. (2004) Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23, 3151-3171
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 191
    • 0027763185 scopus 로고
    • IGF-1 is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes
    • Lorenzo, M., Valverde, A. M., Teruel, T. and Benito, M. (1993) IGF-1 is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes. J. Cell Biol. 123, 1567-1575
    • (1993) J. Cell Biol. , vol.123 , pp. 1567-1575
    • Lorenzo, M.1    Valverde, A.M.2    Teruel, T.3    Benito, M.4
  • 192
    • 0032752007 scopus 로고    scopus 로고
    • Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes requirement of IRS-1 for lipid synthesis
    • Valverde, A. M., Kahn, C. R. and Benito, M. (1999) Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes requirement of IRS-1 for lipid synthesis. Diabetes 48, 2122-2131
    • (1999) Diabetes , vol.48 , pp. 2122-2131
    • Valverde, A.M.1    Kahn, C.R.2    Benito, M.3
  • 193
    • 0034749546 scopus 로고    scopus 로고
    • Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes
    • Fasshauer, M., Klein, J., Kriauciunas, K. M., Ueki, K., Benito, M. and Kahn, C. R. (2001) Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes. Mol. Cell. Biol. 21, 319-329
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 319-329
    • Fasshauer, M.1    Klein, J.2    Kriauciunas, K.M.3    Ueki, K.4    Benito, M.5    Kahn, C.R.6
  • 194
    • 0037322002 scopus 로고    scopus 로고
    • Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation
    • Mur, C., Arribas, M., Benito, M. and Valverde, A. M. (2003) Essential role of insulin-like growth factor I receptor in insulin-induced fetal brown adipocyte differentiation. Endocrinology 144, 581-593
    • (2003) Endocrinology , vol.144 , pp. 581-593
    • Mur, C.1    Arribas, M.2    Benito, M.3    Valverde, A.M.4
  • 195
    • 0030982829 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes
    • Valverde, A. M., Lorenzo, M., Navarro, P. and Benito, M. (1997) Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes. Mol. Endocrinol. 11, 595-607
    • (1997) Mol. Endocrinol. , vol.11 , pp. 595-607
    • Valverde, A.M.1    Lorenzo, M.2    Navarro, P.3    Benito, M.4
  • 196
    • 13244258505 scopus 로고    scopus 로고
    • The brown adipose cell: A model for understanding the molecular mechanisms of insulin resistance
    • Valverde, A. M., Benito, M. and Lorenzo, M. (2005) The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance. Acta Physiol. Scand. 183, 59-73
    • (2005) Acta Physiol. Scand. , vol.183 , pp. 59-73
    • Valverde, A.M.1    Benito, M.2    Lorenzo, M.3
  • 197
    • 0028885873 scopus 로고
    • Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells
    • Yeh, W. C., Bierer, B. E. and Mcknight, S. L. (1995) Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc. Natl. Acad. Sci. U.S.A. 92, 11086-11090
    • (1995) Proc. Natl. Acad. Sci. U.S.A. , vol.92 , pp. 11086-11090
    • Yeh, W.C.1    Bierer, B.E.2    Mcknight, S.L.3
  • 199
    • 4944224365 scopus 로고    scopus 로고
    • Control of 4E-BP1 expression in mouse brown adipose tissue by the β3-adrenoceptor
    • Lehr, L., Kuehne, F., Arboit, P., Giacobino, J. P., Poulin, F., Muzzin, P. and Jimenez, M. (2004) Control of 4E-BP1 expression in mouse brown adipose tissue by the β3-adrenoceptor. FEBS Lett. 576, 179-182
    • (2004) FEBS Lett. , vol.576 , pp. 179-182
    • Lehr, L.1    Kuehne, F.2    Arboit, P.3    Giacobino, J.P.4    Poulin, F.5    Muzzin, P.6    Jimenez, M.7
  • 200
    • 0033590071 scopus 로고    scopus 로고
    • The retinoblastoma gene family in differentiation and development
    • Lipinski, M. M. and Jacks, T. (1999) The retinoblastoma gene family in differentiation and development. Oncogene 18, 7873-7882
    • (1999) Oncogene , vol.18 , pp. 7873-7882
    • Lipinski, M.M.1    Jacks, T.2
  • 201
    • 13244292182 scopus 로고    scopus 로고
    • Novel function of the retinoblastoma protein in fat: Regulation of white versus brown adipocyte differentiation
    • Hansen, J. B., te Riele, H. and Kristiansen, K. (2004) Novel function of the retinoblastoma protein in fat: regulation of white versus brown adipocyte differentiation. Cell Cycle 3, 774-778
    • (2004) Cell Cycle , vol.3 , pp. 774-778
    • Hansen, J.B.1    Te Riele, H.2    Kristiansen, K.3
  • 202
    • 33645221612 scopus 로고    scopus 로고
    • Pocket proteins control white versus brown fat cell differentiation
    • Hansen, J. B. and Kristiansen, K. (2006) Pocket proteins control white versus brown fat cell differentiation. Cell Cycle 5, 341-342
    • (2006) Cell Cycle , vol.5 , pp. 341-342
    • Hansen, J.B.1    Kristiansen, K.2
  • 203
    • 0022541589 scopus 로고
    • Recombinant retroviruses that transduce individual polyoma tumor antigens: Effects on growth and differentiation
    • Cherington, V., Morgan, B., Spiegelman, B. M. and Roberts, T. M. (1986) Recombinant retroviruses that transduce individual polyoma tumor antigens: effects on growth and differentiation. Proc. Natl. Acad. Sci. U.S.A. 83, 4307-4311
    • (1986) Proc. Natl. Acad. Sci. U.S.A. , vol.83 , pp. 4307-4311
    • Cherington, V.1    Morgan, B.2    Spiegelman, B.M.3    Roberts, T.M.4
  • 204
    • 0023971056 scopus 로고
    • Separation of simian virus 40 large-T-antigen-transforming and origin-binding functions from the ability to block differentiation
    • Cherington, V., Brown, M., Paucha, E., St Louis, J., Spiegelman, B. M. and Roberts, T. M. (1988) Separation of simian virus 40 large-T-antigen- transforming and origin-binding functions from the ability to block differentiation. Mol. Cell. Biol. 8, 1380-1384
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 1380-1384
    • Cherington, V.1    Brown, M.2    Paucha, E.3    St. Louis, J.4    Spiegelman, B.M.5    Roberts, T.M.6
  • 205
    • 0035100475 scopus 로고    scopus 로고
    • Cellular transformation by SV40 large T antigen: Interaction with host proteins
    • Ali, S. H. and DeCaprio, J. A. (2001) Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin. Cancer Biol. 11, 15-23
    • (2001) Semin. Cancer Biol. , vol.11 , pp. 15-23
    • Ali, S.H.1    DeCaprio, J.A.2
  • 206
    • 33645064540 scopus 로고    scopus 로고
    • Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α
    • Scimè, A., Grenier, G., Huh, M. S., Gillespie, M. A., Bevilacqua, L., Harper, M. E. and Rudnicki, M. A. (2005) Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α. Cell Metab. 2, 283-295
    • (2005) Cell Metab. , vol.2 , pp. 283-295
    • Scimè, A.1    Grenier, G.2    Huh, M.S.3    Gillespie, M.A.4    Bevilacqua, L.5    Harper, M.E.6    Rudnicki, M.A.7
  • 210
    • 3943054839 scopus 로고    scopus 로고
    • The Sir2 family of protein deacetylases
    • Blander, G. and Guarente, L. (2004) The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 73, 417-435
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 417-435
    • Blander, G.1    Guarente, L.2
  • 212
    • 0036513249 scopus 로고    scopus 로고
    • Does nitric oxide modulate mitochondrial energy generation and apoptosis?
    • Moncada, S. and Erusalimsky, J. D. (2002) Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat. Rev. Mol. Cell Biol. 3, 214-220
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 214-220
    • Moncada, S.1    Erusalimsky, J.D.2
  • 213
    • 0031727870 scopus 로고    scopus 로고
    • Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures
    • Nisoli, E., Clementi, E., Tonello, C., Sciorati, C., Briscini, L. and Carruba, M. O. (1998) Effects of nitric oxide on proliferation and differentiation of rat brown adipocytes in primary cultures. Br. J. Pharmacol. 125, 888-894
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 888-894
    • Nisoli, E.1    Clementi, E.2    Tonello, C.3    Sciorati, C.4    Briscini, L.5    Carruba, M.O.6
  • 216
    • 24344507734 scopus 로고    scopus 로고
    • Krox20 stimulates adipogenesis via C/EBPβ-dependent and -independent mechanisms
    • Chen, Z., Torrens, J. I., Anand, A., Spiegelman, B. M. and Friedman, J. M. (2005) Krox20 stimulates adipogenesis via C/EBPβ-dependent and -independent mechanisms. Cell Metab. 1, 93-106
    • (2005) Cell Metab. , vol.1 , pp. 93-106
    • Chen, Z.1    Torrens, J.I.2    Anand, A.3    Spiegelman, B.M.4    Friedman, J.M.5
  • 217
    • 0034613375 scopus 로고    scopus 로고
    • Function of GATA transcription factors in preadipocyte-adipocyte transition
    • Tong, Q., Dalgin, G., Xu, H., Ting, C. N., Leiden, J. M. and Hotamisligil, G. S. (2000) Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 290, 134-138
    • (2000) Science , vol.290 , pp. 134-138
    • Tong, Q.1    Dalgin, G.2    Xu, H.3    Ting, C.N.4    Leiden, J.M.5    Hotamisligil, G.S.6
  • 218
    • 30944461856 scopus 로고    scopus 로고
    • The transcription factor GATA2 regulates differentiation of brown adipocytes
    • Tsai, J., Tong, Q., Tan, G., Chang, A. N., Orkin, S. H. and Hotamisligil, G. S. (2005) The transcription factor GATA2 regulates differentiation of brown adipocytes. EMBO Rep. 6, 879-884
    • (2005) EMBO Rep. , vol.6 , pp. 879-884
    • Tsai, J.1    Tong, Q.2    Tan, G.3    Chang, A.N.4    Orkin, S.H.5    Hotamisligil, G.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.