Peroxisome proliferator-activated receptors γ and α mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression

Endocrinology

Volumn 139, Issue 12, 1998, Pages 4920-4927

  Kelly, Linda J ^a   Vicario, Pasquale P ^a   Thompson, G Marie ^a   Candelore, Mari R ^a   Doebber, Thomas W ^a   Ventre, John ^a   Wu, Margaret S ^a   Meurer, Roger ^a   Forrest, Michael J ^a   Conner, Michael W ^a   Cascieri, Margaret A ^a   Moller, David E ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; RECEPTOR SUBTYPE; ROSIGLITAZONE; UNCOUPLING PROTEIN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENERGY BALANCE; GENE EXPRESSION REGULATION; LIPID METABOLISM; LIPID VESICLE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; THERMOGENESIS; WHITE ADIPOSE TISSUE;

EID: 7844237506     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.12.6384     Document Type: Article

References (37)

1. Himms-Hagen J 1984 Thermogenesis in brown adipose tissue as an energy buffer. Implication for obesity. N Engl J Med 311:1549-1558
2. Himms-Hagen J 1985 Brown adipose tissue metabolism and thermogenesis. Annu Rev Nutr 5:69-94
3. Brooks SL, Rothwell NJ, Stock MJ, Goodbody AE, Tiayhurn P 1980 Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis. Nature 286:274-276
4. Ricquier D, Bouillaud F, Toumelin P, Mory G, Bazin R, Arch J, Pénicaud L 1986 Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. Evidence for a rapid B-adrenoreceptor-mediated and transcriptionally regulated step during activation of thermogenesis. J Biol Chem 261:13905-13910
5. Rothwell NJ, Stock MJ 1988 Brown adipose tissue: does it play a role in the development of obesity? Diabetes Metab Rev 4:595-601
6. Lowell BB, Susulic S, Hamann A, Lawitts J, Himms-Hagen J, Boyer BB, Kozak LP, Flier JS 1993 Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366:740-742
7. Enerback S, Jacobsson A, Simpson EM, Guerra C, Yamashita H, Harper M-E, Kozak LP 1997 Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387:90-97
8. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH 1997 Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 15:269-272
9. Gimeno RE, Dembski M, Weng X, Deng N, Shyjan AW, Gimeno CJ, Iris F, Ellis SJ, Woolf EA, Tartaglia LA 1997 Cloning and characterization of an uncoupling protein homolog. Diabetes 46:900-906
10. Boss O, Samec S, Paoloni-Giacobino A, Rossier C, Dulloo A, Seydoux J, Muzzin P, Giacobino J-P 1997 Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett 408:39-42
11. Vidal-Puig A, Solanes G, Grujic D, Flier JS, Lowell BB 1997 UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochem Biophys Res Commun 235:79-82
12. Gong D-W, He Y, Karas M, Reitman M 1997 Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta 3-adrenergic agonists, and leptin. J Biol Chem 272:24129-24132
13. Silva JE, Rabelo R 1997 Regulation of the uncoupling protein gene expression. Eur J Endocrinol 136:251-264
14. Berger J, Bailey P, Biswas C, Cullinan CA, Doebber TW, Hayes NS, Saperstein R, Smith RG, Leibowitz MD 1996 Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor-g: binding, and activation correlate with antidiabetic actions in db/db mice. Endocrinology 137:4189-4195
15. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA 1995 An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor g. J Biol Chem 270:12953-12956
16. Foellmi-Adams LA, Wyse BM, Herron D, Nedergaard J, Kletzien RF 1996 Induction of uncoupling protein in brown adipose tissue: synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent. Biochem Pharmacol 52:693-701
17. Tai T-AC, Jennermann C, Brown KK, Oliver BB, MacGinnitie MA, Wilkison WO, Brown HR, Lehmann JM, Kliewer SA, Morris DC, Graves RA 1996 Activation of the nuclear receptor peroxisome proliferator-activated receptor gamma promotes brown adipocyte differentiation. J Biol Chem 271: 29909-29914
18. Vidal-Puig A, Jimenez-Linan M, Hamann A, Lowell BB, Hu E, Spiegelman BM, Flier JS, Moller DE 1996 Regulation of PPARg gene expression in vivo by nutrition and obesity. J Clin Invest 97:2553-2561
19. Tontonoz P, Hu E, Graves R, Budavari A, Spiegelman B 1994 mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8:1224-1234
20. Issemann I, Green S 1990 Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347:645-649
21. Schoonjans K, Staels B, Auwerx J 1996 Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37:907-925
22. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K, Evans RM 1994 Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA 91:7355-7359
23. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
24. Ausubel FM, Brent R, Kingston RE 1987 Current Protocols in Molecular Biology. Moore D, Seidman JG, Smith SA, Struhl K (eds) Wiley and Sons, New York, p 4.9.1
25. Wu M, Ventre J, Moller DE, Doebber T 1997 Correction of elevated glucose and triglycerides in Zucker diabetic fatty rats by thiazolidinediones parallels increased I-glycogen synthase and lipoprotein lipase activity in muscle and fat. Diabetes [Suppl 1]46:237A
26. Mercer SW, Trayhurn P 1986 Effects of ciglitazone on insulin resistance and thermogenic responsiveness to acute cold in brown adipose tissue of genetically obese (ob/ob) mice. FEBS Lett 195:12-16
27. Rothwell NJ, Stock MJ, Tedstone AE 1987 Effects of ciglitazone on energy balance, thermogenesis and brown fat activity in the rat. Mol Cell Endocrinol 57:253-257
28. Tontonoz P, Hu E, Spiegelman BM 1995 Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor g. Curr Biol 5:571-576
29. Rabelo R, Camirand A, Silva JE 1997 3′,5′-cyclic adenosine monophosphate-response sequences of the uncoupling protein gene are sequentially recruited during darglitazone-induced brown adipocyte differentiation. Endocrinology 138:5325-5332
30. Sears IB, MacGinnitie MA, Kovacs LG, Graves RA 1996 Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma. Mol Cell Biol 16:3410-3419
31. Camirand A, Marie V, Rabelo R, Silva JE 1998 Thiazolidinediones stimulate uncoupling piotein-2 expression in cell lines representing white and brown adipose tissues and skeletal muscle. Endocrinology 139:428-431
32. Aubert J, Champigny O, Saint-Marc P, Negrel R, Collins S, Ricquier D, Ailhaud G 1997 Up-regulation of UCP-2 gene expression by PPAR agonists in preadipose and adipose cells. Biochem Biophys Res Commun 238:606-611
33. Boss O, Samec S, Dulloo A, Seydoux J, Muzzin P, Giacobino J-P 1997 Tissue-dependent up-regulation of rat uncoupling protein-2 expression in response to fasting or cold. FEBS Lett 412:111-114
34. Boss O, Samec S, Kuhne F, Bijlenga P, Assimacopoulos-Jeannet F, Seydoux J, Giacobino J-P, Muzzin P 1998 Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature. J Biol Chem 273:5-8
35. Millet L, Vidai H, Andreelli F, Larrouy D, Riou J-P, Ricquier D, Laville M, Langin D 1997 Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. J Clin Invest 100:2665-2670
36. Kozak LP, Kozak UC, Clarke GT 1991 Abnormal brown and white fat development in transgenic mice overexpressing glycerol 3-phosphate dehydrogenase. Genes Dev 5:2256-2264
37. Assimacopoulos-Jeannet F, Moinat M, Muzzin P, Colomb C, Jeanrenaud B, Girardier L, Giacobino J-P, Seydoux J 1991 Effects of a peroxisome proliferator on b-oxidation and overall energy balance in obese (fa/fa) rats. Am J Physiol 260:R278-R283