Lipoatrophic diabetes in Irs1-/-/Irs3-/- double knockout mice

Genes and Development

Volumn 16, Issue 24, 2002, Pages 3213-3222

  Laustsen, Palle G ^a   Michael, M Dodson ^a   Crute, Barbara E ^b   Cohen, Shmuel E ^a   Ueki, Kohjiro ^a   Kulkarni, Rohit N ^a   Keller, Susanna R ^b   Lienhard, Gustav E ^a   Kahn, C Ronald ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Adipogenesis; Insulin receptor substrate; Leptin; Lipoatrophic diabetes

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INSULIN RECEPTOR SUBSTRATE 3; INSULIN RECEPTOR SUBSTRATE 4; UNCLASSIFIED DRUG;

ADENOVIRUS; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; CELL SPECIFICITY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLUCOSE HOMEOSTASIS; HORMONE RECEPTOR INTERACTION; HYPERINSULINEMIA; HYPOGLYCEMIA; INSULIN BINDING; INSULIN RESISTANCE; KNOCKOUT MOUSE; LIPOATROPHIC DIABETES MELLITUS; LIPOGENESIS; LIVER; MALE; MOUSE; MUSCLE TISSUE; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ADENOVIRIDAE; ADIPOSE TISSUE; ANIMALS; DIABETES MELLITUS, LIPOATROPHIC; DISEASE MODELS, ANIMAL; FATTY ACIDS, NONESTERIFIED; GLUCOSE; HYPERGLYCEMIA; HYPERINSULINISM; IMMUNOENZYME TECHNIQUES; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; LEPTIN; MICE; MICE, KNOCKOUT; PHOSPHOPROTEINS; TRANSFECTION; TRIGLYCERIDES;

ADENOVIRIDAE; ANIMALIA;

EID: 0037115464     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1034802     Document Type: Article

References (28)

1. Almind, K., Bjorbaek, C., Vestergaard, H., Hansen, T., Echwald, S., and Pedersen, O. 1993. Amino acid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 342: 828-832.
2. Araki, E., Lipes, M.A., Patti, M.E., Bruning, J.C., Haag III, B., Johnson, R.S., and Kahn, C.R. 1994. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372: 186-190.
3. Ebihara, K., Ogawa, Y., Masuzaki, H., Shintani, M., Miyanaga, F., Aizawa-Abe, M., Hayashi, T., Hosoda, K., Inoue, G., Yoshimasa, Y., et al. 2001. Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes. Diabetes 50: 1440-1448.
4. Fantin, V.R., Lavan, B.E., Wang, Q., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Keller, S.R., and Lienhard, G.E. 1999. Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene. Endocrinology 140: 1329-1337.
5. Fantin, V.R., Wang, Q., Lienhard, G.E., and Keller, S.R. 2000. Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am. J. Physiol. Endocrinol. Metab. 278: E127-E133.
6. Fasshauer, M., Klein, J., Ueki, K., Kriauciunas, K.M., Benito, M., White, M.F., and Kahn, C.R. 2000. Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J. Biol. Chem. 275: 25494-25501.
7. Fasshauer, M., Klein, J., Kriauciunas, K.M., Ueki, K., Benito, M., and Kahn, C.R. 2001. Essential role of insulin receptor substrate 1 in differentiation of brown adipocytes. Mol. Cell. Biol. 21: 319-329.
8. Flier, S.N., Kulkarni, R.N., and Kahn, C.R. 2001. Evidence for a circulating islet cell growth factor in insulin-resistant states. Proc. Natl. Acad. Sci. 98: 7475-7480.
9. Gavrilova, O., Marcus-Samuels, B., Leon, L.R., Vinson, C., and Reitman, M.L. 2000. Leptin and diabetes in lipoatrophic mice. Nature 403: 850-851.
10. Imai, Y., Fusco, A., Suzuki, Y., Lesniak, M.A., D'Alfonso, R., Sesti, G., Bertoli, A., Lauro, R., Accili, D., and Taylor, S.I. 1994. Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 79: 1655-1658.
11. Kieffer, T.J. and Habener, J.F. 2000. The adipoinsular axis: Effects of leptin on pancreatic β-cells. Am. J. Physiol. Endocrinol. Metab. 278: E1-E14.
12. Kubota, N., Tobe, K., Terauchi, Y., Eto, K., Yamauchi, T., Suzuki, R., Tsubamoto, Y., Komeda, K., Nakano, R., Miki, H., et al. 2000. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory β-cell hyperplasia. Diabetes 49: 1880-1889.
13. Kulkarni, R.N., Wang, Z.L., Wang, R.M., Hurley, J.D., Smith, D.M., Ghatei, M.A., Withers, D.J., Gardiner, J.V., Bailey, C.J., and Bloom, S.R. 1997. Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J. Clin. Invest. 100: 2729-2736.
14. Kulkarni, R.N., Winnay, J.N., Daniels, M., Bruning, J.C., Flier, S.N., Hanahan, D., and Kahn, C.R. 1999. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured β-cell lines. J. Clin. Invest. 104: R69-R75.
15. Laakso, M., Malkki, M., Kekalainen, P., Kuusisto, J., and Deeb, S.S. 1994. Insulin receptor substrate-1 variants in non-insulin-dependent diabetes. J. Clin. Invest. 94: 1141-1146.
16. Liu, S.C., Wang, Q., Lienhard, G.E., and Keller, S.R. 1999. Insulin receptor substrate 3 is not essential for growth or glucose homeostasis. J. Biol. Chem. 274: 18093-18099.
17. Michael, M.D., Kulkarni, R.N., Postic, C., Previs, S.F., Shulman, G.I., Magnuson, M.A., and Kahn, C.R. 2000. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6: 87-97.
18. Miyake, S., Makimura, M., Kanegae, Y., Harada, S., Sato, Y., Takamori, K., Tokuda, C., and Saito, I. 1996. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc. Natl. Acad. Sci. 93: 1320-1324.
19. Oral, E.A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A.J., DePaoli, A.M., Reitman, M.L., Taylor, S.I., et al. 2002. Leptin-replacement therapy for lipodystrophy. N. Engl. J. Med. 346: 570-578.
20. Reitman, M.L., Arioglu, E., Gavrilova, O., and Taylor, S.I. 2000. Lipoatrophy revisited. Trends Endocrinol. Metab. 11: 410-416.
21. Rosen, E.D. and Spiegelman, B.M. 2000. Molecular regulation of adipogenesis. Annu. Rev. Cell Dev. Biol. 16: 145-171.
22. Saltiel, A.R. and Kahn, C.R. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806.
23. Sciacchitano, S. and Taylor, S.I. 1997. Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene. Endocrinology 138: 4931-4940.
24. Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S., and Goldstein, J.L. 1999. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401: 73-76.
25. Tamemoto, H., Kadowaki, T., Tobe, K., Yagi, T., Sakura, H., Hayakawa, T., Terauchi, Y., Ueki, K., Kaburagi, Y., Satoh, S., et al. 1994. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature 372: 182-186.
26. Virkamaki, A., Ueki, K., and Kahn, C.R. 1999. Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J. Clin. Invest. 103: 931-943.
27. Whitehead, J.P., Humphreys, P., Krook, A., Jackson, R., Hayward, A., Lewis, H., Siddle, K., and O'Rahilly, S. 1998. Molecular scanning of the insulin receptor substrate 1 gene in subjects with severe insulin resistance: Detection and functional analysis of a naturally occurring mutation in a YMXM motif. Diabetes 47: 837-839.
28. Withers, D.J., Gutierrez, J.S., Towery, H., Burks, D.J., Ren, J.M., Previs, S., Zhang, Y., Bernal, D., Pons, S., Shulman, G.I., et al. 1998. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391: 900-904.