Cidea-deficient mice have lean phenotype and are resistant to obesity

Nature Genetics

Volumn 35, Issue 1, 2003, Pages 49-56

  Zhou, Zhihong ^a   Toh, Shen Yon ^a   Chen, Zhengming ^a   Guo, Ke ^a   Ng, Chee Peng ^a   Ponniah, Sathivel ^a   Lin, Sheng Cai ^a   Hong, Wanjin ^a   Li, Peng ^a,b  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; DNA FRAGMENT; NORADRENALIN; UNCOUPLING PROTEIN 1;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; CELL DEATH; CONTROLLED STUDY; CORE TEMPERATURE; DIMERIZATION; ENERGY BALANCE; ENERGY EXPENDITURE; HYPERGLYCEMIA; INSULIN RESISTANCE; LEAN BODY WEIGHT; LIPOLYSIS; METABOLIC RATE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; THERMOGENESIS; THERMOREGULATION;

ANIMALIA;

EID: 0041353552     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1225     Document Type: Article

References (26)

1. Spiegelman, B.M. & Flier, J.S. Obesity and the regulation of energy balance. Cell 104, 531-543 (2001).
2. Lowell, B.B. & Spiegelman, B.M. Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-660 (2000).
3. Lowell, B.B. & Flier, J.S. Brown adipose tissue, β-3-adrenergic receptors, and obesity. Annu. Rev. Med. 48, 307-316 (1997).
4. Himms-Hagen, J. Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J. 4, 2890-2898 (1990).
5. Klingenberg, M. & Echtay, K.S. Uncoupling proteins: the issues from a biochemist point of view. Biochim. Biophys. Acta. 1504, 128-143 (2001).
6. Enerback, S. et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 387, 90-94 (1997).
7. Bouillaud, F. et al. A sequence related to a DNA recognition element is essential for the inhibition by nucleotides of proton transport through the mitochondrial uncoupling protein. EMBO J. 13, 1990-1997 (1994).
8. Echtay, K.S., Winkler, E. & Klingenberg, M. Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature 408, 609-613 (2000).
9. Dulloo, A.G. & Miller, D.S. Energy balance following sympathetic denervation of brown adipose tissue. Can. J. Physiol. Pharmacol. 62, 235-240 (1984).
10. Lowell, B.B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (1993).
11. Kopecky, J., Clarke, G., Enerback, S., Spiegelman, B. & Kozak, L.P. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J. Clin. Invest. 96, 2914-2923 (1995).
12. Clapham, J.C. et al. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406, 415-418 (2000).
13. Bachman, E.S. et al. βAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297, 843-845 (2002).
14. Liu, X. et al. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J. Clin. Invest. 111, 399-407 (2003).
15. Kozak, L.P., Kozak, U.C. & Clarke, G.T. Abnormal brown and white fat development in transgenic mice overexpressing glycerol 3-phosphate dehydrogenase. Genes Dev. 5, 2256-2264 (1991).
16. Inohara, N., Koseki, T., Chen, S., Wu, X. & Nunez, G. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 17, 2526-2533 (1998).
17. Zhou, P., Lugovskoy, A.A., McCarty, J.S., Li, P. & Wagner, G. Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. Proc. Natl. Acad. Sci. USA 98, 6051-6055 (2001).
18. Lugovskoy, A.A. et al. Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. Cell 99, 747-755 (1999).
19. Chen, Z., Guo, K., Toh, S.Y., Zhou, Z. & Li, P. Mitochondria localization and dimerization are required for CIDE-8 to induce apoptosis. J. Biol. Chem. 275, 22619-22622 (2000).
20. Tsukiyama-Kohara, K. et al. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat. Med. 7, 1128-1132 (2001).
21. Sambrook, J., Fritsch, E.F. & Maniatis, T. Molecular Cloning: A Laboratory Manual (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1989).
22. Klein, J. et al. β(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J. Biol. Chem. 274, 34795-34802 (1999).
23. Haemmerle, G. et al. Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. J. Biol. Chem. 277, 4806-4815 (2002).
24. Carson, F.L. Histotechnology: A Self-Instructional Text 2nd edn. (American Society for Clinical Pathology Press, Chicago, 1997).
25. Lucocq, J. Unbiased 3-D quantitation of ultrastructure in cell biology. Trends Cell Biol. 3, 354-358 (1993).
26. db/db mice. Nat. Genet. 26, 474-479 (2000).