Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent

Biochemical Pharmacology

Volumn 52, Issue 5, 1996, Pages 693-701

  Foellmi Adams, Lisa A ^a   Wyse, Beatrice M ^a   Herron, David ^b   Nedergaard, Jan ^b   Kletzien, Rolf F ^a  

^a PFIZER INC   (United States)

^b STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

brown adipose tissue; diabetes; insulin resistance; norepinephrine; pioglitazone; uncoupling protein

Indexed keywords

NORADRENALIN; PIOGLITAZONE; UNCOUPLING PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DIABETES MELLITUS; MOUSE; NONHUMAN; OBESITY; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0030582447     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(96)00345-0     Document Type: Article

References (36)

1. 1. Smith RE and Horwitz BA, Brown fat and thermogenesis. Physiol Rev 49: 330-352, 1969.
2. 2. Rothwell NJ and Stock MJ, A role for brown adipose tissue in diet-induced thermogenesis. Nature 281: 31-35, 1979.
3. 3. Himms-Hagen J, Brown adipose tissue thermogenesis and obesity. Prog Lipid Res 28: 67-115, 1989.
4. 4. Lowell BB, Susulic VS, Hamann A, Lawitts JA, Himms-Hagen J, Boyer BB, Kozak LP and Flier JS, Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366: 740-742, 1993.
5. 5. Mercer SW and Trayhurn P, The development of insulin resistance in brown adipose tissue may impair the acute cold-induced activation of thermogenesis in genetically obese (ob/ ob) mice. Biosci Rep 4: 933-940, 1984.
6. 6. Nicholls DG and Locke RM, Thermogenic mechanisms in brown fat. Physiol Rev 64: 1-64, 1984.
7. 7. Ricquier D, Bouillaud F, Toumelin P, Mory G, Bazin R, Arch J and Penicaud L, Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. J Biol Chem 261: 13905-13910, 1986.
8. 8. Bouillaud F, Ricquier D, Mory G and Thiabult J, Increased level of mRNA for the uncoupling protein in brown adipose tissue in rats during thermogenesis induced by cold exposure or norepinephrine infusion. J Biol Chem 259: 11583-11586, 1984.
9. 9. Bianco AC, Sheng X and Silva JE, Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem 263: 18168-18175, 1988.
10. 10. Herron D, Rehnmark S, Néchard M, Lončar D, Cannon B and Nedergaard J, Norepinephrine-induced synthesis of the uncoupling protein thermogenin (UCP) and its mitochondrial targeting in brown adipocytes differentiated in culture. FEBS Lett 268: 296-300, 1990.
11. 11. Rehnmark S, Néchad M, Herron D, Cannon B and Nedergaard J, α-and β-Adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. J Biol Chem 265: 16464-16471, 1990.
12. 12. Kletzien RF, Clarke SD and Ulrich RG, Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Mol Pharmocol 41: 393-398, 1992.
13. 13. Kletzien RF, Foellmi LA, Harris PK, Wyse BM and Clarke SD, Adipocyte fatty acid-binding protein: Regulation of gene expression in vivo and in vitro by an insulin-sensitizing agent. Mol Pharmacol 42: 558-562, 1992.
14. 14. Ikeda H, Taketomi S, Sugiyama Y, Shimura Y, Shoda T, Meguro K and Fujita T, Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals. Arzneimittelforsschung 40: 156-162, 1990.
15. 15. Colca JR, Dailey CF, Palazuk BJ, Hillman RM, Dinh DM, Melchoir GW and Spilman CH, Pioglitazone hydrochloride inhibits cholesterol absorption and lowers plasma cholesterol concentrations in cholesterol-fed rats. Diabetes 40: 1669-1674, 1991.
16. 16. Chang AY, Wyse BM, Gilchrist BJ, Peterson T and Diani AR, Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes 32: 830-838, 1983.
17. 17. Rothwell NJ, Stock MJ and Tedstone AE, Effects of ciglitazone on energy balance, thermogenesis and brown fat activity in the rat. Mol Cell Endocrinol 51: 253-257, 1987.
18. 18. Mercer SW and Trayhurn P, Effects of ciglitazone on insulin resistance and thermogenic responsiveness to acute cold in brown adipose tissue of genetically obese (ob/ob) mice. FEBS Lett 195: 12-16, 1986.
19. 19. Smith AW, Houpt KA, Kitchell RL, Kohn DF, McDonald LE, Passaglia M Jr, Thurmon JC and Ames ER, 1986 Report of the AVMA Panel on Euthanasia. J Am Vet Med Assoc 188: 252-268, 1986.
20. 20. Néchad M, Kuusela P, Carnheim C, Bjorntorp P, Nedergaard J and Cannon B, Development of brown fat cells in monolayer culture: Morphological and biochemical distinction from white fat cells in culture. Exp Cell Res 149: 105-118, 1983.
21. 21. Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources Commission on Life Sciences, Guide for the Care and Use of Laboratory Animals, DHEW Publication (NIH) No. 86-23. National Institutes of Health, Bethesda, MD, 1985.
22. 22. Ridley RG, Patel HV, Gerber GE, Morton RC and Freeman KB, Complete nucleotide and derived amino acid sequence of cDNA encoding the mitochondrial uncoupling protein for rat brown adipose tissue: Lack of mitochondrial targeting presequence. Nucleic Acids Res 14: 4025-4035, 1986.
23. 23. Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB and Erlich HA, Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239: 487-491, 1988.
24. 24. Hunt CR, Ro HS, Dobson DE, Mia HY and Spiegelman BM, Adipocyte P2 gene: Developmental expression and homology to 5′-flanking sequences among fat cell-specific genes. Proc Natl Acad Sci USA 83: 3786-3790, 1986.
25. 25. Sugiyama Y, Taketomi S, Shimura Y, Ikeda H and Fujita T, Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats. Arzneimittelforschung 40: 263-267, 1990.
26. 26. Smith PK, Krohn RI, Hernamson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ and Klenk DC, Measurement of protein using bicinchoninic acid. Anal Biochem 150: 76-85, 1985.
27. 27. Harlow E and Lane D, Antibodies; A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, 1988.
28. 28. Cannon B, Hedin A and Nedergaard J, Exclusive occurrence of thermogenin antigen in brown adipose tissue. FEBS Lett 150: 129-132, 1982.
29. 29. Yang VW, Christy RJ, Cook JS, Kelly TJ and Lane MD, Mechanism of regulation of the 422(aP2) gene by cAMP during preadipocyte differentiation. Proc Natl Acad Sci USA 86: 3629-3633, 1989.
30. 30. Ross SR, Graves RA, Greenstein A, Platt KA, Shyu H-L, Mellovitz B and Spiegelman BM, A fat-specific enhancer is the primary determinant of gene expression for adipocyte Ps in vivo. Proc Natl Acad Sci USA 87: 9590-9594, 1990.
31. 31. Pico C, Herron D, Palou A, Jacobsson A, Cannon B and Nedergaard J, Stabilization of the mRNA for the uncoupling protein thermogenin by transcriptional/translational blockade and by noradrenaline in brown adipocytes differentiated in culture: A degradation factor induced by cessation of stimulation? Biochem J 302: 81-86, 1994.
32. 32. Jacobsson A, Muhleisen M, Cannon B and Nedergaard J, The uncoupling protein thermogenin during acclimation: Indication for pretranslational control. Am J Physiol 267: R999-R1007, 1994.
33. 33. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM and Kliewer SA, An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem 270: 12953-12956, 1995.
34. 34. Harris PKH and Kletzien RF, Localization of a pioglitazone response element in the adipocyte fatty acid binding protein gene. Mol Pharmacol 45: 439-445, 1994.
35. 35. Tontonoz P, Hu E, Graves RA, Budavari AI and Spiegelman BM, mPPAR2γ: Tissue specific regulator of an adipocyte enhancer. Genes Dev 8: 1224-1234, 1994.
36. 36. Minden A, Lin A, McMahon M, Lange-Carter C, Dérijard B, Davis RJ, Johnson GL and Karin M, Differential activation of ERK and JNK mitogen-activated protein kinases by raf-1 and MEKK. Science 266: 1719-1723, 1994.