Peroxisome proliferator-activated receptor γ agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice

Endocrinology

Volumn 145, Issue 8, 2004, Pages 3925-3934

  Sell, Henrike ^a   Berger, Joel P ^b   Samson, Pierre ^a   Castriota, Gino ^b   Lalonde, Josée ^a   Deshaies, Yves ^a   Richard, Denis ^a,c  

^a LAVAL UNIVERSITY   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 2 [2 (4 PHENOXY 2 PROPYLPHENOXY)ETHYL]INDOLE 5 ACETIC ACID; 5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; BETA 3 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; GLUCOSE; INSULIN; LIPOPROTEIN LIPASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

ADRENERGIC STIMULATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BROWN ADIPOSE TISSUE; CALORIMETRY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ELECTRON MICROSCOPY; ENERGY EXPENDITURE; FEMALE; FOOD INTAKE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; LIPID METABOLISM; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; RESPIRATORY QUOTIENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYMPATHETIC TONE; THERMOGENESIS; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANIMALS; BASE SEQUENCE; BODY COMPOSITION; ENERGY METABOLISM; FEMALE; ION CHANNELS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, OBESE; MITOCHONDRIAL PROTEINS; MOLECULAR SEQUENCE DATA; OBESITY; PLANT PROTEINS; RECEPTORS, ADRENERGIC, BETA-3; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 3843083938     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0321     Document Type: Article

References (48)

1. Spiegelman BM 1998 PPAR-γ: adipogenic regulator and thiazolidinedione receptor. Diabetes 47:507-514
2. Yamauchi T, Kamon J, Waki H, Murakami K, Motojima K, Komeda K, Ide T, Kubota N, Terauchi Y, Tobe K, Miki H, Tsuchida A, Akanuma Y, Nagai R, Kimura S, Kadowaki T 2001 The mechanisms by which both heterozygous peroxisome proliferator-activated receptor γ (PPAR-γ) deficiency and PPARγ agonist improve insulin resistance. J Biol Chem 276:41245-41254
3. Sinha D, Addya S, Murer E, Boden G 1999 15-Deoxy-Δ(12,14) prostaglandin J2: a putative endogenous promoter of adipogenesis suppresses the ob gene. Metabolism 786-791
4. Bernardo A, Levi G, Minghetti L 2000 Role of the peroxisome proliferator-activated receptor-γ (PPAR-γ) and its natural ligand 15-deoxy-Δ12, 14-prostaglandin J2 in the regulation of microglial functions. Eur J Neurosci 12:2215-2223
5. Chinetti G, Fruchart JC, Staels B 2000 Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res 10:497-505
6. Okuno A, Tamemoto H, Tobe K, Ueki K, Mori Y, Iwamoto K, Umesono K, Akanuma Y, Fujiwara T, Horikoshi H, Yazaki Y, Kadowaki T 1998 Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 101:1354-1361
7. Kelly LJ, Vicario PP, Thompson GM, Candelore MR, Doebber TW, Ventre J, Wu MS, Meurer R, Forrest MJ, Conner MW, Cascieri MA, Moller DE 1998 Peroxisome proliferator-activated receptors y and a mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression. Endocrinology 139:4920-4927
8. Emilsson V, O'Dowd J, Wang S, Liu YL, Sennitt M, Heymart R, Cawthorne MA 2000 The effects of rexinoids and rosiglitazone on body weight and uncoupling protein isoform expression in the Zucker fa/fa rat. Metabolism 1610-1615
9. Fukui Y, Masui S, Osada S, Umesono K, Motojima K 2000 A new thiazolidinedione, NC-2100, which is a weak PPAR-γ activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. Diabetes 49:759-767
10. Sears IB, MacGinnitie MA, Kovacs LG, Graves RA 1996 Differentiation- dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor γ. Mol Cell Biol 16:3410-3419
11. Nedergaard J, Golozoubova V, Matthias A, Asadi A, Jacobsson A, Cannon B 2001 UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta 1504:82-106
12. Arbeeny CM, Meyers DS, Hillyer DE, Bergquist KE 1995 Metabolic alterations associated with the antidiabetic effect of β3-adrenergic receptor agonists in obese mice. Am J Physiol 268:E678-E684
13. Rothwell NJ, Stock MJ 1997 A role for brown adipose tissue in diet-induced thermogenesis. Obes Res 5:650-656
14. Ricquier D, Bouillaud F 2000 Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance. J Physiol 529:3-10
15. Suzuki A, Yasuno T, Kojo H, Hirosumi J, Mutoh S, Notsu Y 2000 Alteration in expression profiles of a series of diabetes-related genes in db/db mice following treatment with thiazolidinediones. Jpn J Pharmacol 84:113-123
16. Wang Q, Dryden S, Frankish HM, Bing C, Pickavance L, Hopkins D, Buckingham R, Williams G 1997 Increased feeding in fatty Zucker rats by the thiazolidinedione BRL 49653 (rosiglitazone) and the possible involvement of leptin and hypothalamic neuropeptide Y. Br J Pharmacol 122:1405-1410
17. Burkey BF, Dong M, Gagen K, Eckhardt M, Dragonas N, Chen W, Grosenstein P, Argentieri G, de Souza CJ 2000 Effects of pioglitazone on promoting energy storage, not expenditure, in brown adipose tissue of obese fa/fa Zucker rats: comparison to CL 316,243. Metabolism 49:1301-1308
18. Berger J, Tanen M, Elbrecht A, Hermanowski-Vosatka A, Moller DE, Wright SD, Thieringer R 2001 Peroxisome proliferator-activated receptor-γ ligands inhibit adipocyte 11β-hydroxysteroid dehydrogenase type 1 expression and activity. J Biol Chem 276:12629-12635
19. Desvergne B, Wahli W 1999 Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20:649-688
20. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM 1998 A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-839
21. Esser V, Brown NF, Cowan AT, Foster DW, McGarry JD 1996 Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of camitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT 1 isoform expressed in both white (epididymal) and brown adipocytes. J Biol Chem 271:6972-6977
22. Carley AN, Semeniuk LM, Shimoni Y, Aasum E, Larsen TS, Berger JP, Severson DL 2003 Treatment of type 2 diabetic db/db mice with a novel PPAR-γ agonist improves cardiac metabolism but not contractile function. Am J Physiol Endocrinol Metab 286:E449-E455
23. Nagy TR, Clair AL 2000 Precision and accuracy of dual-energy x-ray absorptiometry for determining in vivo body composition of mice. Obes Res 8:392-398
24. 3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138:405-413
25. 3-adrenergic agonist, CL 316 243, on energy expenditure and epididymal adipocyte lipolytic activity in rat. Comp Biochem Physiol A Mol Integr Physiol 119:629-636
26. Olefsky JM 2000 Treatment of insulin resistance with peroxisome proliferator-activated receptor γ agonists. J Clin Invest 106:467-472
27. Picard F, Auwerx J 2002 PPARγ and glucose homeostasis. Annu Rev Nutr 22:167-197
28. Chatelain F, Kohl C, Esser V, McGarry JD, Girard J, Pegorier JP 1996 Cyclic AMP and fatty acids increase carnitine palmitoyltransferase I gene transcription in cultured fetal rat hepatocytes. Eur J Biochem 235:789-798
29. Mascara C, Acosta E, Ortiz JA, Marrera PF, Hegardt FG, Haro D 1998 Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J Biol Chem 273:8560-8563
30. Yamazaki N, Shinohara Y, Shima A, Yamanaka Y, Terada H 1996 Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I. Biochim Biophys Acta 1307:157-161
31. Barbera MJ, Schluter A, Pedraza N, Iglesias R, Villarroya F, Giralt M 2001 Peroxisome proliferator-activated receptor α activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J Biol Chem 1486-1493
32. Tiraby C, Tavernier G, Lefort C, Larrouy D, Bouillaud F, Ricquier D, Langin D 2003 Acquirement of brown fat cell features by human white adipocytes. J Biol Chem 278:33370-33376
33. Butow RA, Bahassi EM 1999 Adaptive thermogenesis: orchestrating mitochondrial biogenesis. Curr Biol 9:R767-R769
34. Bakopanos E, Suva JE 2000 Thiazolidinediones inhibit the expression of β3-adreneigic receptors at a transcriptional level. Diabetes 49:2108-2115
35. Laplante M, Sell H, MacNaul KL, Richard D, Berger JP, Deshaies Y 2003 PPAR-γ activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. Diabetes 52:291-299
36. Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Penicaud L, Casteilla L 1992 Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 103:931-942
37. Himms-Hagen J, Cui J, Danforth Jr E, Taatjes DJ, Lang SS, Waters BL, Claus TH 1994 Effect of CL-316,243, a thermogenic β3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol 266:R1371-R1382
38. Surwit RS, Wang S, Petro AE, Sanchis D, Raimbault S, Ricquier D, Collins S 1998 Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. Proc Natl Acad Sci USA 95:4061-4065
39. Griggio MA 1982 The participation of shivering and nonshivering thermogenesis in warm and cold-acclimated rats. Comp Biochem Physiol A 73:481-484
40. Hamilton JM, Mason PW, McElroy JF, Wade GN 1986 Dissociation of sympathetic and thermogenic activity in brown fat of Syrian hamsters. Am J Physiol 250:R389-R395
41. McElroy JF, Wade GN 1986 Short photoperiod stimulates brown adipose tissue growth and thermogenesis but not norepinephrine turnover in Syrian hamsters. Physiol Behav 37:307-311
42. Sigurdson SL, Himms-Hagen J 1988 Control of norepinephrine turnover in brown adipose tissue of Syrian hamsters. Am J Physiol 254:R960-R968
43. Foellmi-Adams LA, Wyse BM, Herron D, Nedergaard J, Kletzien RF 1996 Induction of uncoupling protein in brown adipose tissue. Synergy between norepinephrine and pioglitazone, an insulin-sensitizing agent. Biochem Pharmacol 52:693-701
44. Soumano K, Desbiens S, Rabelo R, Bakopanos E, Camirand A, Silva JE 2000 Glucocorticoids inhibit the transcriptional response of the uncoupling protein-1 gene to adrenergic stimulation in a brown adipose cell line. Mol Cell Endocrinol 165:7-15
45. Onai T, Kilroy G, York DA, Bray GA 1995 Regulation of β3-adrenergic receptor mRNA by sympathetic nerves and glucocorticoids in BAT of Zucker obese rats. Am J Physiol 269:R519-R526
46. Wolf G 2002 Glucocorticoids in adipocytes stimulate visceral obesity. Nutr Rev 60:148-151
47. Matthias A, Ohlson KB, Fredriksson JM, Jacobsson A, Nedergaard J, Cannon B 2000 Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty acid-induced thermogenesis. J Biol Chem 275:25073-25081
48. Tordjman J, Chauvet G, Quette J, Beale EG, Forest C, Antoine B 2003 Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells. J Biol Chem 278:18785-18790