Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia

Endocrinology

Volumn 137, Issue 1, 1996, Pages 21-29

  Hamann, Andreas ^a,b   Flier, Jeffrey S ^a   Lowell, Bradford B ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE PREDISPOSITION; FAT INTAKE; FEMALE; HYPERGLYCEMIA; HYPERLIPIDEMIA; HYPERPHAGIA; INSULIN RESISTANCE; LIPID DIET; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0030021071     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.1.8536614     Document Type: Article

References (35)

1. Rothwell NJ, Stock MJ 1979 A role for brown adipose tissue in diet induced thermogenesis. Nature 281:31-35
2. Klaus S, Casteilla L, Boillard F, Ricquier D 1991 The uncoupling protein UCP: a membraneous mitochondrial ion carrier exclusively expressed in brown adipose tissue. Int J Biochem 23:780-791
3. Nicholls DG, Locke RM 1984 Thermogenic mechanisms in brown fat. Physiol Rev 64:1-64
4. Himms-Hagen J 1991 Neural control of brown adipose tissue thermogenesis, hypertrophy and atrophy. Front Neuroendocrinol 12: 38-93
5. Glick Z, Teague RJ, Bray GA 1981 Brown adipose tissue: thermic response increased by a single low protein, high carbohydrate meal. Science 213:1125-1127
6. Brooks SL, Rothwell NJ, Stock MJ, Goodbody AE, Trayhurn P 1980 Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis. Nature 286:274-276
7. Richard D, Boily P, Dufresne MC, Lecompte M 1988 Energy balance and facultative diet-induced thermogenesis in mice fed a high fat diet. Can J Physiol Pharmacol 66:1297-1302
8. Lowell BB, S-Susulic V, Hamann A, Lawitts JA, Himms-Hagen J, Boyer BB, Kozak LP, Flier JS 1993 Development of obesity in transgenic mice following the genetic ablation of brown adipose tissue. Nature 366:740-742
9. Salmon DMV, Flatt JP 1985 Effect of dietary fat content on the incidence of obesity among ad libitum fed mice. Int J Obesity 9:443-449
10. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
11. Jakubowski M, Roberts JL 1992 Multiplex solution hybridization-ribonuclease protection assay for quantitation of different ribonucleic acid transcripts from snap-frozen neuroendocrine tissues of individual animals. J Neuroendocrinol 4:79-89
12. Hotamisligil GS, Shargill NS, Spiegelman BM 1993 Adipose expression of tumor necrosis factor-α: direct role in obesity linked insulin resistance. Science 259:87-90
13. Muzzin P, Revelli JP, Kuhne F, Gocayne JD, McCombie WR, Venter JC, Giacobino JP, Fraser CM 1991 An adipose tissue specific β-adrenergic receptor. J Biol Chem 266:24053-24058
14. 1-adrenergic receptors in adipose tissue of congentitally obese (C57BL/6J ob/ob) mice. Mol Endocrinol 8:518-527
15. 14a Hamann A, Benecke H, Le Marchand-Brustel Y, Susulic VS, Lowell BB, Flier JS Diabetes, in press
16. Schemmel R, Michelson O, Tolgay Z 1969 Dietary obesity in rats: influence of diet, weight, age, and sex on body composition. Am J Physiol 216:373-379
17. West DB, Boozer CN, Moody DL, Atkinson RL 1992 Dietary obesity in nine inbred mouse strains. Am J Physiol 262:R1025-R1032
18. Schemmel R, Mickelsen O, Gill JL 1970 Dietary obesity in rats: body weight and body fat accretion in seven strains of rats. J Nutr 100:1041-1048
19. Schwartz JH, Young JB, Landsberg L 1983 Effect on dietary fat on sympathetic nervous system activity in the rat. J Clin Invest 72:361-370
20. Silva JE, Larsen PR 1983 Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature 305:712-713
21. Bianco AC, Sheng X, Silva JE 1988 Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem 263:18168-18175
22. Rabolli D, Martin RJ 1977 Effects of diet composition on serum levels of insulin, thyroxine, triiodothyronine, growth hormone, and corticosterone in rats. J Nutr 107:1068-1074
23. Danforth E, Horton ES, O'Connell M, Sims EA, Burger AG, Ingbar SH, Braverman L, Vagenakis AG 1979 Dietary induced alterations in thyroid hormone metabolism during overnutrition. J Clin Invest 64:1336-1347
24. Debuc PU 1977 Basal corticosterone levels of young ob/ob mice. Horm Metab Res 9:95-97
25. Coleman DL, Hummel KP 1974 Hyperinsulinemia in preweaning diabetes (db) mice. Diabetologia 10:607-610
26. Kraegen EW, James DE, Storlien LH, Burleigh KM, Chisholm DJ 1986 In vivo insulin resistance in individual peripheral tissues of the high fat fed rat: assessment by euglycemic clamp plus deoxyglucose administration. Diabetologia 29:192-198
27. Storlien LH, Pan DA, Kriketos AD, Baur LA 1993 High fat diet-induced insulin resistance. Lessons and implications from animal studies. Ann NY Acad Sci 683:82-90
28. Kahn BB 1992 Facilitative glucose transporters: regulatory mechanisms and dysregulation in diabetes. J Clin Invest 89:1367-1374
29. Pedersen O, Kahn CR, Flier JS, Kahn BB 1991 High fat feeding causes insulin resistance and a marked decrease in the expression of glucose transporters (Glut 4) in fat cells of rats. Endocrinology 129: 771-777
30. Eckel RH 1992 Insulin resistance: an adaptation for weight maintenance. Lancet 340:1452-1453
31. Swinburn BA, Nyomba BL, Saad MF, Zurlo F, Raz I, Knowler WC, Lillioja S, Bogardus C, Ravussin E 1991 Insulin resistance associated with lower rates of weight gain in Pima Indians. J Clin Invest 89:1964-1973
32. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM 1994 Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes: central role of tumor necrosis factor-α. J Clin Invest 94: 1543-1549
33. 3-adrenergic receptor responsiveness in 3T3-F442A adipose differentiation. J Biol Chem 267:15909-15915
34. DeFronzo RA, Ferrannini E 1991 Insulin resistance, a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194
35. Reaven GM 1991 Insulin resistance, hyperinsulinemia, hypertriglyceridemia and hypertension. Parallels between human disease and rodent models. Diabetes Care 14:195-202