The impact of ancillary subunits on small-molecule interactions with voltage-gated potassium channels

Current Pharmaceutical Design

Volumn 12, Issue 18, 2006, Pages 2285-2302

  Panaghie, Gianina ^a   Abbott, Geoffrey W ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

hERG; IKr; IKs; KChAP; KChIP; KCNE

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; ANTIARRHYTHMIC AGENT; AZIMILIDE; BENZODIAZEPINE DERIVATIVE; BUDIPINE; BUPIVACAINE; CHLOROQUINE; CHROMANOL 293B; CISAPRIDE; CLARITHROMYCIN; COTRIMOXAZOLE; DOFETILIDE; FLUVOXAMINE; LEVOBUPIVACAINE; MACROLIDE; MEFENAMIC ACID; N [3 HYDROXY 2,2 DIMETHYL 6 (4,4,4 TRIFLUOROBUTOXY)CHROMAN 4 YL] N METHYLMETHANESULFONAMIDE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNQ1; POTASSIUM ION; QUINIDINE; ROPIVACAINE; SOTALOL; SULFAMETHOXAZOLE; TERFENADINE; TRIMETHOPRIM; UNINDEXED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ALPHA CHAIN; ARTICLE; BETA CHAIN; CELL MEMBRANE; CYTOPLASM; DEPOLARIZATION; DRUG BINDING; DRUG BINDING SITE; DRUG POTENCY; DRUG TARGETING; EPILEPSY; GENE MUTATION; HEART ARRHYTHMIA; HUMAN; IN VIVO STUDY; ION TRANSPORT; LONG QT SYNDROME; MORPHOLOGY; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REPOLARIZATION; TORSADE DES POINTES;

ANIMALS; HEART; HUMANS; ION CHANNEL GATING; KCNQ1 POTASSIUM CHANNEL; KV CHANNEL-INTERACTING PROTEINS; MYOCARDIUM; NEURONS; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SUBUNITS; TETRAETHYLAMMONIUM;

EID: 33745169339     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161206777585175     Document Type: Article

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