Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain

Molecular Pharmacology

Volumn 63, Issue 5, 2003, Pages 1051-1058

  Sǎnchez Chapula, Jose A ^a   Ferrer, Tania ^a   Navarro Polanco, Ricardo A ^a   Sanguinetti, Michael C ^b  

^a UNIVERSIDAD DE COLIMA   (Mexico)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; ANTIARRHYTHMIC AGENT; CARDIOTONIC AGENT; CHLOROQUINE; PIPERANOMETOZINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; QUINIDINE; QUININE; TERFENADINE;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG BINDING SITE; DRUG POTENCY; ELECTRIC POTENTIAL; GENE; GENE MUTATION; HEART MUSCLE POTENTIAL; HUMAN ETHER A GO GO RELATED GENE; IC 50; MEMBRANE DEPOLARIZATION; MOLECULAR INTERACTION; NONHUMAN; PH; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

BINDING SITES; CATION TRANSPORT PROTEINS; DNA-BINDING PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MEMBRANE PROTEINS; PHOSPHODIESTERASE INHIBITORS; POINT MUTATION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN STRUCTURE, TERTIARY; QUINIDINE; QUININE; QUINOLINES; TRANS-ACTIVATORS; TYROSINE;

EID: 0038407463     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.5.1051     Document Type: Article

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