Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate

Journal of General Physiology

Volumn 115, Issue 3, 2000, Pages 229-239

  Mitcheson, John S ^a   Chen, Jun ^a   Sanguinetti, Michael C ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

MK 499; Voltage clamp; Xenopus oocyte

Indexed keywords

1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; ANTIARRHYTHMIC AGENT; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SULFONAMIDE;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CHANNEL GATING; DRUG MECHANISM; DRUG PROTEIN BINDING; HYPERPOLARIZATION; NONHUMAN; REPOLARIZATION; XENOPUS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BENZOPYRANS; CATION TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUTATION, MISSENSE; OOCYTES; PATCH-CLAMP TECHNIQUES; PIPERIDINES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; XENOPUS;

EID: 0033818157     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.115.3.229     Document Type: Article

References (33)

1. MiRP1 forms I(Kr) potassium channels with HERG and is associated with cardiac arrhythmia
2. Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injected in squid axon
3. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons
4. + current in cardiac myocytes by dofetilide
5. Selective I(Kr) potassium channel blockers as class III antiarrhythmic agents
6. + conduction and selectivity
7. + channels
8. Expression of ion channels by injection of mRNA into Xenopus oocytes
9. Preparation of RNA for injection into Xenopus oocytes
10. Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels
11. Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
12. + channels
13. Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels
14. + channel in rabbit sinoatrial node cells
15. Molecular physiology and pharmacology of HERG: Single-channel currents and block by dofetilide
16. Structural conservation in prokaryotic and eukaryotic potassium channels
17. + channels during gating and assembly
18. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the I(Kr) potassium channel
19. Mutations of the S4-S5 linker alter activation properties of HERG potassium channels expressed in Xenopus oocytes
20. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
21. + channels
22. The inward rectification mechanism of the HERG cardiac potassium channel
23. High affinity open channel block by dofetilide of HERG expressed in a human cell line
24. + channel; open channel block by methanesulfonanilides
25. Fast inactivation causes rectification of the I(Kr) channel
26. Tetraethylammonium ions and the potassium permeability of excitable cells
27. The inhibition of sodium currents in myelinated nerve by quarternary derivatives of lidocaine
28. Electrophysiological recording from Xenopus oocytes
29. HERG, a human inward rectifier in the voltage-gated potassium channel family
30. Regulation of deactivation by an amino terminal domain in Human Ether-a-go-go-related Gene potassium channels
31. +](o) and C-type inactivation
32. The moving parts of voltage-gated ion channels
33. + channels in Xenopus oocytes