Probing the interaction between inactivation gating and D-sotalol block of HERG

Circulation Research

Volumn 87, Issue 11, 2000, Pages 1012-1018

  Numaguchi, Hirotaka ^a   Mullins, Franklin M ^a   Johnson Jr , J P ^a   Johns, David C ^c   Po, Sunny S ^b   Yang, Iris C H ^a   Tomaselli, Gordon F ^b   Balser, Jeffrey R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE

Author keywords

Antiarrhythmic drugs; HERG; Inactivation; Potassium channel

Indexed keywords

ANILIDE; ANTIARRHYTHMIC AGENT; CADMIUM; MEMBRANE PROTEIN; POTASSIUM CHANNEL; SODIUM ION; SOTALOL;

ARTICLE; BINDING AFFINITY; CHANNEL GATING; DRUG RECEPTOR BINDING; DRUG TARGETING; ELECTRIC POTENTIAL; GENE MUTATION; HEART ARRHYTHMIA; HYPERPOLARIZATION; MEMBRANE DEPOLARIZATION; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 0034711465     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.11.1012     Document Type: Article

References (32)

1. + current: Differential sensitivity to block by crass III antiarrhythmic agents
2. Suppression of time-dependent outward current in guinea pig ventricular myocytes: Actions of quinidine and amiodarone
3. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the I(Kr) potassium channel
4. HERG, a human inward rectifier in the voltage-gated potassium channel family
5. Class III antiarrhythmic drug block HERG, a human cardiac delayed rectifier K channel: Open-channel block by methanesulfonanilides
6. High affinity open channel block by dofetilide of HERG expressed in a human cell line
7. HERG, a primary human ventricular target of the nonsedating antihistamine terfenadine
8. Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole
9. + channel by the gastrointestinal prokinetic agent cisapride
10. Blockade of HERG and Kv1.5 by ketoconazole
11. The inward rectification mechanism of the HERG cardiac potassium channel
12. Time, voltage, and ionic concentration dependence of rectification of HERG expressed in Xenopus oocytes
13. Molecular physiology and pharmacology of HERG: Single-channel currents and block by dofetilide
14. Molecular determinants for activation and inactivation of HERG, a human inward rectifier potassium channel
15. + Channels
16. +](o) and C-type inactivation
17. Molecular determinant of high-affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: Involvement of S6 sites
18. + channels expressed in Xenopus oocytes
19. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate
20. 2+ destabilization of the inactivated state
21. Effects of N-acetylprocainamide and sotalol on ion currents in isolated guinea-pig ventricular myocytes
22. Differential effects of the new class HI antiarrhythmic agents almokalant, E-4031 and D-sotalol, and of quinidine, on delayed rectifier currents in guinea pig ventricular myocytes
23. Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant negative KV4.2 constructs
24. Fast inactivation causes rectification of the I(Kr) channel
25. A quantitative analysis of the activation and inactivation kinetics of HERG expressed in Xenopus oocytes
26. MiRP1 forms I(Kr) potassium channels with HERG and is associated with cardiac arrhythmia
27. A sensitive mechanism for cation modulation of potassium current
28. + channels: Effects of alterutions in the carboxy-terminal region
29. Dynamic rearrangement of the outer mouth of a K channel during gating
30. Time course of TEA-induced anomalous rectification in squid giant axons
31. Extracellular potassium modulation of drug block of I(Kr): Implications for torsade de pointes and reverse use-dependence
32. Residues underlying HERG C-type inactivation mediate external K sensitivity and D-sotalol block through distinct mechanisms