Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family

Journal of Molecular Biology

Volumn 343, Issue 4, 2004, Pages 1055-1065

  Strop, Pavel ^a   Bankovich, Alexander J ^b   Hansen, Kirk C ^c   Christopher Garcia, K ^b   Brunger, Axel T ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

dipeptidyl aminopeptidase; DPP6; DPPX; serine protease; voltage gated potassium channel

Indexed keywords

DIPEPTIDYL AMINOPEPTIDASE X; DIPEPTIDYL PEPTIDASE; PROTEIN SUBUNIT; SERINE PROTEINASE; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CRYSTAL STRUCTURE; ELECTRIC ACTIVITY; GLYCOSYLATION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTON TRANSPORT; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; SURFACE PROPERTY;

EID: 5144227957     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.09.003     Document Type: Article

References (64)

1. Y. Kin, Y. Misumi, and Y. Ikehara Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein J. Biochem. (Tokyo) 129 2001 289 295
2. K. Wada, N. Yokotani, C. Hunter, K. Doi, R.J. Wenthold, and S. Shimasaki Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family Proc. Natl Acad. Sci. USA 89 1992 197 201
3. M.S. Nadal, A. Ozaita, Y. Amarillo, E. Vega-Saenz de Miera, Y. Ma, and W. Mo The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels Neuron 37 2003 449 461
4. M.D. Gorrell First bite Nature Struct. Biol. 10 2003 3 5
5. M.J. Scanlan, B.K. Raj, B. Calvo, P. Garin-Chesa, M.P. Sanz-Moncasi, and J.H. Healey Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers Proc. Natl Acad. Sci. USA 91 1994 5657 5661
6. V. Fulop, Z. Bocskei, and L. Polgar Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis Cell 94 1998 161 170
7. C.A. Abbott, D.M. Yu, E. Woollatt, G.R. Sutherland, G.W. McCaughan, and M.D. Gorrell Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8 Eur. J. Biochem. 267 2000 6140 6150
8. S.Y. Qi, P.J. Riviere, J. Trojnar, J.L. Junien, and K.O. Akinsanya Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases Biochem. J. 373 2003 179 189
9. J.S. Rosenblum, and J.W. Kozarich Prolyl peptidases: a serine protease subfamily with high potential for drug discovery Curr. Opin. Chem. Biol. 7 2003 496 504
10. L. Polgar The prolyl oligopeptidase family Cell Mol. Life Sci. 59 2002 349 362
11. R. Mentlein Dipeptidyl-peptidase IV (CD26) - role in the inactivation of regulatory peptides Regul. Pept. 85 1999 9 24
12. H.B. Rasmussen, S. Branner, F.C. Wiberg, and N. Wagtmann Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog Nature Struct. Biol. 10 2003 19 25
13. N. Yokotani, K. Doi, R.J. Wenthold, and K. Wada Non-conservation of a catalytic residue in a dipeptidyl aminopeptidase IV-related protein encoded by a gene on human chromosome 7 Hum. Mol. Genet. 2 1993 1037 1039
14. B. Hille Ion Channels of Excitable Membranes 3rd edit. 2001 Sinauer Associates Sunderland
15. P.S. Herson, and J.P. Adelman It takes two to tango, but three to ISA Neuron 37 2003 370 372
16. L.Y. Jan, and Y.N. Jan Voltage-gated and inwardly rectifying potassium channels J. Physiol. 505 1997 267 282
17. W.J. Song Genes responsible for native depolarization-activated K+ currents in neurons Neurosci. Res. 42 2002 7 14
18. J.E. Dixon, W. Shi, H.S. Wang, C. McDonald, H. Yu, and R.S. Wymore Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current Circ. Res. 79 1996 659 668
19. G.N. Tseng Molecular structure of cardiac Ito channels: Kv4.2, Kv4.3, and other possibilities? Cardiovasc. Res. 41 1999 16 18
20. G.C. Amberg, S.D. Koh, Y. Imaizumi, S. Ohya, and K.M. Sanders A-type potassium currents in smooth muscle Am. J. Physiol. Cell Physiol. 284 2003 C583 C595
21. A.A. Grace, B.S. Bunney, H. Moore, and C.L. Todd Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs Trends Neurosci. 20 1997 31 37
22. B. Liss, O. Franz, S. Sewing, R. Bruns, H. Neuhoff, and J. Roeper Tuning pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription EMBO J. 20 2001 5715 5724
23. M.S. Nadal, Y. Amarillo, E. Vega-Saenz de Miera, and B. Rudy Evidence for the presence of a novel Kv4-mediated A-type K(+) channel-modifying factor J. Physiol. 537 2001 801 809
24. K. Takimoto, and X. Ren KChIPs (Kv channel-interacting proteins) - a few surprises and another J. Physiol. 545 2002 3
25. W.F. An, M.R. Bowlby, M. Betty, J. Cao, H.P. Ling, and G. Mendoza Modulation of A-type potassium channels by a family of calcium sensors Nature 403 2000 553 556
26. L.A. Kim, J. Furst, M.H. Butler, S. Xu, N. Grigorieff, and S.A. Goldstein Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2 J. Biol. Chem. 279 2004 5549 5554
27. Jerng, H. H. & Pfaffinger, P. J. (2004). Biophysical Meeting Online Abstract, The Biophysical Society.
28. C. Oefner, A. D'Arcy, A. Mac Sweeney, S. Pierau, R. Gardiner, and G.E. Dale High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano- (S)-pyrrol idine Acta Crystallog. D 59 2003 1206 1212
29. M. Engel, T. Hoffmann, L. Wagner, M. Wermann, U. Heiser, and R. Kiefersauer The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism Proc. Natl Acad. Sci. USA 100 2003 5063 5068
30. K. Aertgeerts, S. Ye, M.G. Tennant, M.L. Kraus, J. Rogers, and B.C. Sang Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation Protein Sci. 13 2004 412 421
31. J. Cedano, P. Aloy, J.A. Perez-Pons, and E. Querol Relation between amino acid composition and cellular location of proteins J. Mol. Biol. 266 1997 594 600
32. A. Stark, and R.B. Russell Annotation in three dimensions. PINTS: Patterns in Non-homologous Tertiary Structures Nucl. Acids Res. 31 2003 3341 3344
33. M.A. Wilson, J.L. Collins, Y. Hod, D. Ringe, and G.A. Petsko The 1.1-Å resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease Proc. Natl Acad. Sci. USA 100 2003 9256 9261
34. J.M. Gulbis, S. Mann, and R. MacKinnon Structure of a voltage-dependent K+ channel beta subunit Cell 97 1999 943 952
35. J.M. Gulbis, M. Zhou, S. Mann, and R. MacKinnon Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels Science 289 2000 123 127
36. J.M. Gulbis The beta subunit of Kv1 channels: voltage-gated enzyme or safety switch? Novartis Found. Symp. 245 2002 127 165
37. J. Kameoka, T. Tanaka, Y. Nojima, S.F. Schlossman, and C. Morimoto Direct association of adenosine deaminase with a T cell activation antigen, CD26 Science 261 1993 466 469
38. A.C. Girardi, B.C. Degray, T. Nagy, D. Biemesderfer, and P.S. Aronson Association of Na(+)-H(+) exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubule J. Biol. Chem. 276 2001 46671 46677
39. E.J. Neer, C.J. Schmidt, R. Nambudripad, and T.F. Smith The ancient regulatory-protein family of WD-repeat proteins Nature 371 1994 297 300
40. L. Yu, C. Gaitatzes, E. Neer, and T.F. Smith Thirty-plus functional families from a single motif Protein Sci. 9 2000 2470 2476
41. G. Schmitt-Ulms, K.C. Hansen, J. Liu, C. Cowdrey, J. Yang, and S.J. DeArmond In vivo analysis of protein interactions involving the prion protein using time-controlled transcardiac perfusion crosslinking Nature Biotechnol. 22 2004 724 731
42. L. de Lecea, E. Soriano, J.R. Criado, S.C. Steffensen, S.J. Henriksen, and J.G. Sutcliffe Transcripts encoding a neural membrane CD26 peptidase-like protein are stimulated by synaptic activity Brain Res. Mol. Brain Res. 25 1994 286 296
43. R.B. Hough, A. Lengeling, V. Bedian, C. Lo, and M. Bucan Rump white inversion in the mouse disrupts dipeptidyl aminopeptidase-like protein 6 and causes dysregulation of Kit expression Proc. Natl Acad. Sci. USA 95 1998 13800 13805
44. L.A. Kim, J. Furst, D. Gutierrez, M.H. Butler, S. Xu, S.A. Goldstein, and N. Grigorieff Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 angstrom resolution Neuron 41 2004 513 519
45. R.B. Bass, P. Strop, M. Barclay, and D.C. Rees Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel Science 298 2002 1582 1587
46. Y. Jiang, A. Lee, J. Chen, V. Ruta, M. Cadene, B.T. Chait, and R. MacKinnon X-ray structure of a voltage-dependent K+ channel Nature 423 2003 33 41
47. Y.F. Melman, A. Krummerman, and T.V. McDonald KCNE regulation of KvLQT1 channels: structure-function correlates Trends Cardiovasc. Med. 12 2002 182 187
48. M. Pourrier, G. Schram, and S. Nattel Properties, expression and potential roles of cardiac K+ channel accessory subunits: MinK, MiRPs, KChIP, and KChAP J. Membr. Biol. 194 2003 141 152
49. G.W. Abbott, S.A. Goldstein, and F. Sesti Do all voltage-gated potassium channels use MiRPs? Circ. Res. 88 2001 981 983
50. H. Chen, L.A. Kim, S. Rajan, S. Xu, and S.A. Goldstein Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex Neuron 40 2003 15 23
51. W. Wang, J. Xia, and R.S. Kass MinK-KvLQT1 fusion proteins, evidence for multiple stoichiometries of the assembled IsK channel J. Biol. Chem. 273 1998 34069 34074
52. N. Zerangue, B. Schwappach, Y.N. Jan, and L.Y. Jan A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels Neuron 22 1999 537 548
53. Z. Otwinowski, and W. Minor Processing of X-ray diffraction data collected in oscillation mode Methods Enzymol. 276 1997 307 326
54. A. Fiser, and A. Sali Modeller: generation and refinement of homology-based protein structure models Methods Enzymol. 374 2003 461 491
55. S. Bailey The CCP4 suite - programs for protein crystallography Acta Crystallog. D 50 1994 760 763
56. T.A. Jones, J.Y. Zou, S.W. Cowan, and M. Kjeldgaard Improved methods for building protein models in electron-density maps and the location of errors in these models Acta Crystallog. A 47 1991 110 119
57. A.T. Brunger, P.D. Adams, G.M. Clore, W.L. DeLano, P. Gros, and R.W. Grosse-Kunstleve Crystallography and NMR system: a new software suite for macromolecular structure determination Acta Crystallog. D 54 1998 905 921
58. R.A. Laskowski, J.A. Rullmannn, M.W. MacArthur, R. Kaptein, and J.M. Thornton AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR J. Biomol. NMR 8 1996 477 486
59. A. Nicholls, and B. Honig GRASP: Graphical Representation and Analysis of Surface Properties 1992 Columbia University New York
60. N.A. Baker, D. Sept, S. Joseph, M.J. Holst, and J.A. McCammon Electrostatics of nanosystems: application to microtubules and the ribosome Proc. Natl Acad. Sci. USA 98 2001 10037 10041
61. R.H. Scannevin, K. Wang, F. Jow, J. Megules, D.C. Kopsco, and W. Edris Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1 Neuron 41 2004 587 598
62. W. Zhou, Y. Qian, K. Kunjilwar, P.J. Pfaffinger, and S. Choe Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels Neuron 41 2004 573 586
63. T.D. Fenn, D. Ringe, and G.A. Petsko POVScript+ program for model and data visualization using persistence of vision ray tracing J. Appl. Crystallog. 36 2003 944 947
64. P.J. Kraulis MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures J. Appl. Crystallog. 24 1991 946 950