Control of human potassium channel inactivation by editing of a small mRNA hairpin

Nature Structural and Molecular Biology

Volumn 11, Issue 10, 2004, Pages 950-956

  Bhalla, Tarun ^a   Rosenthal, Joshua J C ^b   Holmgren, Miguel ^c   Reenan, Robert ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF PUERTO RICO MEDICAL SCIENCES CAMPUS   (Puerto Rico)

^c NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE DEAMINASE; MESSENGER RNA; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV1.1; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CHANNEL GATING; DEAMINATION; DROSOPHILA MELANOGASTER; DROSOPHILA MELANOGASTER SHAB; DROSOPHILA MELANOGASTER SHAKER; ELECTRICITY; ELECTROPHYSIOLOGY; GENE MUTATION; HUMAN; INTRON; POTASSIUM CHANNEL GENE; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM; RNA EDITING; RNA STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; DROSOPHILA MELANOGASTER; HUMANS; KV1.1 POTASSIUM CHANNEL; MOLECULAR SEQUENCE DATA; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RNA EDITING; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 4744347763     PISSN: 15459993     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsmb825     Document Type: Article

References (41)

1. Hille, B. Ion Channels of Excitable Membranes (Sinauer Associates, Sunderland, Massachusetts, USA, 2001).
2. + channels with altered functional properties. Neuron 19, 711-722 (1997).
3. + channel regulates subunit tetramerization. Neuron 30, 743-757 (2002).
4. Hoopengardner, B., Bhalla, T., Staber, C. & Reenan, R. Nervous system targets of RNA editing identified by comparative genomics. Science 301, 832-836 (2003).
5. Seeburg, P. & Hartner, J. Regulation of ion channel/neurotransmitter receptor function by RNA editing. Curr. Opin. Neurobiol. 13, 279-283 (2003).
6. Higuchi, M. et al. RNA editing of AMPA receptor subunit GluR-B: a base-paired intron-exon structure determines position and efficiency. Cell 75, 1361-1370 (1993).
7. Herb, A., Higuchi, M., Sprengel, R. & Seeburg, P. Q/R site editing in kainate receptor GluR5 and GluR6 pre-mRNAs requires distant intronic sequences. Proc. Natl. Acad. Sci. USA 93, 1875-1880 (1996).
8. Burns, C. et al. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 387, 303-308 (1997).
9. Aruscavage, P. & Bass, B. A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing. RNA 6, 257-269 (2000).
10. Dawson, T., Sansam, C. & Emeson, R. Structure and sequence determinants required for the RNA editing of ADAR2 substrates. J. Biol. Chem. 279, 4941-4951 (2004).
11. Zuker, M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31, 3406-3415 (2003).
12. + channel. Neuron 19, 175-184 (1997).
13. + conduction and selectivity. Science 280, 69-77 (1998).
14. Zhou, M., Morais-Cabral, J., Mann, S. & MacKinnon, R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature 411, 657-661 (2001).
15. + channels altered by presence of β-subunit. Nature 369, 289-294 (1994).
16. Singer-Lahat, D., Dascal, N. & Lotan, I. Modal behavior of the Kv1.1 channel conferred by the Kvβ1.1 subunit and its regulation by dephosphorylation of Kv1.1. Pflugers Arch. 439, 18-26 (1999).
17. + channel composed of Kv1.1 and Kvβ1.1 subunits modulated by G protein β γ subunits. EMBO J. 18, 1245-1256 (1999).
18. + channel α subunit modulates the inactivation conferred by a β subunit. Involvement of cytoskeleton. J. Biol. Chem. 271, 29321-29328 (1996).
19. + channels expressed in Xenopus oocytes. Biochemistry 33, 8786-8792 (1994).
20. Wang, Z., Kiehn, J., Yang, Q., Brown, A.M. & Wible, B.A. Comparison of binding and block produced by alternatively spliced Kvβ1 subunits. J. Biol. Chem. 271, 28311-28317 (1996).
21. Hoshi, T., Zagotta, W. & Aldrich, R. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science 250, 533-538 (1990).
22. Murrell-Lagnado, R. & Aldrich, R. Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic peptides. J. Gen. Physiol. 102, 949-975 (1993).
23. + channels block by inactivation peptides. J. Gen. Physiol. 102, 977-1003 (1993).
24. Palladino, M.J., Keegan, L.P., O'Connell, M.A. & Reenan, R.A. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell 102, 437-449 (2000).
25. Poison, A.G. & Bass, B.L. Preferential selection of adenosines for modification by double-stranded RNA adenosine deaminase. EMBO J. 13, 5701-5711 (1994).
26. Liu, Y., George, C., Patterson, J. & Samuel, C. Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase. J. Biol. Chem. 272, 4419-4428 (1997).
27. Yang, J. et al. Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation. Immunology 109, 15-23 (2003).
28. + channel behaves like an open-channel blocker. Neuron 7, 743-753 (1991).
29. + channels. Biophys. J. 67, 1806-1815 (1994).
30. + current by frequency and external [K+]: a tale of two inactivation mechanisms. Neuron 15, 951-960 (1995).
31. Connor, J.A. & Steven, C.F. Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma. J Physiol. 213, 31-53 (1971).
32. Aldrich R.W., Getting P.A. & Thompson, S.H. Mechanism of frequency-dependent broadening of molluscan neurone soma spikes. J Physiol. 291, 531-544 (1979).
33. + conductance in hippocampus. Nature 389, 286-289 (1997).
34. + channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387, 869-875 (1997).
35. + channel inactivation, spike broadening, and after-hyperpolarization in Kvβ1.1-deficient mice with impaired learning. Learn. Mem. 5, 257-273 (1998).
36. Herson, P.S. et al. A mouse model of episodic ataxia type-1. Nat. Neurosci. 6, 378-383 (2003).
37. Kawahara, Y. et al. Glutamate receptors: RNA editing and death of motor neurons. Nature 427, 801 (2004).
38. Higuchi, M. et al. Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2. Nature 406, 78-81 (2000).
39. Kamb, A., Tseng-Crank, J. & Tanouye, M.A. Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity. Neuron 1, 421-430 (1988).
40. Jurman, M.E., Boland, L.M., Liu, Y. & Yellen, G. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques 17, 876-881 (1994).
41. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391, 85-100 (1981).