Local anaesthetic sensitivities of cloned HERG channels from human heart: Comparison with HERG/MiRP1 and HERG/MiRP1T8A

British Journal of Anaesthesia

Volumn 92, Issue 1, 2004, Pages 93-101

  Friederich, Patrick ^a   Solth, A ^a   Schillemeit, S ^a   Isbrandt, D ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Anaesthetics local; Anaesthetics, toxicity; Complications, arrythmia

Indexed keywords

AMIDE; BUPIVACAINE; LEVOBUPIVACAINE; LOCAL ANESTHETIC AGENT; POTASSIUM CHANNEL HERG; POTASSIUM ION; PROTEIN SUBUNIT; ROPIVACAINE;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CARDIOTOXICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SENSITIVITY; DRUG TARGETING; GENETIC RISK; HEART ARRHYTHMIA; HEART VENTRICLE; IC 50; MOLECULAR CLONING; MUTATION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS;

EID: 0348227676     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aeh026     Document Type: Article

References (23)

1. Kasten GW. Amide local anesthetic alterations of effective refractory period temporal dispersion: relationship to ventricular arrhythmias. Anesthesiology 1986; 65: 61-6
2. Chang DH, Ladd LA, Copeland S, Iglesias MA, Plummer JL, Mather LE. Direct cardiac effects of intracoronary bupivacaine, levobupivacaine and ropivacaine in the sheep. Br J Pharmacol 2001; 132: 649-58
3. Roden DM, Lazzara R, Rosen M, Schwartz PJ, Towbin J, Vincent GM. Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS. Circulation 1996; 94: 1996-2012
4. Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995; 81: 299-307
5. Splawski I, Shen J, Timothy KW, Vincent GM, Lehmann MH, Keating MT. Genomic structure of three long QT syndrome genes: KVLQTI, HERG, and KCNEI. Genomics 1998; 51: 86-97
6. Trudeau MC, Warmke JW, Ganetzky B, Robertson GA. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science 1995; 269: 92-5
7. Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell 2001; 104: 569-80
8. Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC. A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci USA 2000; 97: 12329-33
9. Lipka LJ, Jiang M, Tseng GN. Differential effects of bupivacaine on cardiac K channels: role of channel inactivation and subunit composition in drug-channel interaction. J Cardiovasc Electrophysiol 1998; 9: 727-42
10. Gonzalez T, Longobardo M, Caballero R, Delpon E, Tamargo J, Valenzuela C. Effects of bupivacaine and a novel local anesthetic, IQB-9302, on human cardiac K+ channels. J Pharmacol Exp Ther 2001; 296: 573-83
11. Gonzalez T, Arias C, Caballero R, et al. Effects of levobupivacaine, ropivacaine and bupivacaine on HERG channels: stereoselective bupivacaine block. Br J Pharmacol 2002; 137: 1269-79
12. Abbott GW, Sesti F, Splawski I, et al. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 1999; 97: 175-87
13. Mazhari R, Greenstein JL, Winslow RL, Marban E, Nuss HB. Molecular interactions between two long-QT syndrome gene products, HERG and KCNE2, rationalized by in vitro and in silico analysis. Circ Res 2001; 89: 33-8
14. Sesti F, Abbott GW, Wei J, et al. A common polymorphism associated with antibiotic-induced cardiac arrhythmia. Proc Natl Acad Sci USA 2000; 97: 10613-18
15. Roden DM, Balser JR, George AL Jr, Anderson ME. Cardiac ion channels. Annu Rev Physiol 2002; 64: 431-75
16. Gonzalez T, Navarro-Polanco R, Arias C, et al. Assembly with the Kvbeta 1.3 subunit modulates drug block of hKv 1.5 channels. Mol Pharmacol 2002; 62: 1456-63
17. Isbrandt D, Friederich P, Solth A, et al. A novel mutation in the KCNE2 (MiRP1) gene that alters HERG channel kinetics. J Mol Med 2002; 80: 524-32
18. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 1981; 391: 85-100
19. Barry PH, Lynch JW. Liquid junction potentials and small cell effects in patch-clamp analysis. J Membr Biol 1991; 121: 101-17
20. Hancox JC, Levi AJ, Witchel HJ. Time course and voltage dependence of expressed HERG current compared with native 'rapid' delayed rectifier K current during the cardiac ventricular action potential. Pflugers Arch 1998; 436: 843-53
21. Smith PL, Baukrowitz T, Yellen G. The inward rectification mechanism of the HERG cardiac potassium channel. Nature 1996; 379: 833-6
22. Weerapura M, Nattel S, Chartier D, Caballero R, Hebert TE. A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link? J Physiol 2002; 540: 15-27
23. Nau C, Wang SY, Strichartz GR, Wang GK. Block of human heart hHI sodium channels by the enantiomers of bupivacaine. Anesthesiology 2000; 93: 1022-33