Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism

FASEB Journal

Volumn 16, Issue 3, 2002, Pages 390-400

  Abbott, Geoffrey W ^a   Goldstein, Steve A N ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Section of Developmental Biology and Biophysics   (United States)

Author keywords

Cardiac arrhythmia; HERG; KCNQ1; Kv3.4; MinK; MiRP1; MiRP2; Periodic paralysis

Indexed keywords

ARGININE; ASPARAGINE; ASPARTIC ACID; GENE PRODUCT; HISTIDINE; POTASSIUM CHANNEL; PROTEIN MINK; PROTEIN MIRP1; PROTEIN MIRP2; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE ACTIVITY; GENE FUNCTION; GENE MUTATION; HEART ARRHYTHMIA; MOLECULAR INTERACTION; NONHUMAN; PARALYSIS; POINT MUTATION; POTASSIUM CURRENT; PRIORITY JOURNAL; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; ARRHYTHMIA; CATION TRANSPORT PROTEINS; CELLS, CULTURED; CONSERVED SEQUENCE; COS CELLS; DNA-BINDING PROTEINS; ELECTRIC CONDUCTIVITY; ETHER-A-GO-GO POTASSIUM CHANNELS; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; POINT MUTATION; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN SUBUNITS; SEQUENCE ALIGNMENT; SHAW POTASSIUM CHANNELS; TRANS-ACTIVATORS; UP-REGULATION;

ANIMALIA; MUSTELA VISON;

EID: 0036190347     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0520hyp     Document Type: Article

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