Binding of correolide to the Kv1.3 potassium channel: Characterization of the binding domain by site-directed mutagenesis

Biochemistry

Volumn 40, Issue 39, 2001, Pages 11687-11697

  Hanner, M ^a   Green, B ^a   Gao, Y D ^a   Schmalhofer, W A ^a   Matyskiela, M ^a   Durand, D J ^a   Felix, J P ^a   Linde, A R ^a   Bordallo, C ^a   Kaczorowski, G J ^a   Kohler, M ^a   Garcia, M L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY BINDING;

HYDROPHOBICITY; MEMBRANES; POTASSIUM;

MUTAGENESIS;

CORREOLIDE; IMMUNOSUPPRESSIVE AGENT; LIGAND; POTASSIUM CHANNEL; TETRAMER; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MEMBRANE BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

ALANINE; BINDING SITES; KV1.3 POTASSIUM CHANNEL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN BINDING; PROTEIN CONFORMATION; THERMODYNAMICS; TRITERPENES;

RUMEX;

EID: 0035797891     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0111698     Document Type: Article

References (48)