Structural conservation in prokaryotic and eukaryotic potassium channels

Science

Volumn 280, Issue 5360, 1998, Pages 106-109

  MacKinnon, Roderick ^a   Cohen, Steven L ^a   Kuo, Anling ^a   Lee, Alice ^a   Chait, Brian T ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; SCORPION VENOM;

AMINO ACID SEQUENCE; ARTICLE; CHANNEL GATING; GENETIC CONSERVATION; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STREPTOMYCES LIVIDANS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; CHARYBDOTOXIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POINT MUTATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; RECOMBINANT PROTEINS; SCORPION VENOMS; SEQUENCE ALIGNMENT; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STREPTOMYCES;

EUKARYOTA; LEIURUS; LEIURUS QUINQUESTRIATUS HEBRAEUS; PROKARYOTA; SCORPIONES; STREPTOMYCES LIVIDANS;

EID: 0032478696     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5360.106     Document Type: Article

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27. We thank J. Gulbis, J. P. Imredy, and D. A. Doyle for assistance in preparation of the figures and helpful discussions on the work. Supported by NIH GM43949. R.M. is an investigator in the Howard Hughes Medical Institute.