Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels

Journal of Physiology

Volumn 552, Issue 2, 2003, Pages 369-378

  Seebohm, Guiscard ^a,b   Sanguinetti, Michael C ^a   Pusch, Michael ^c  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN SUBUNIT; RUBIDIUM; RUBIDIUM ION; POTASSIUM CHANNEL KCNE1; POTASSIUM CHANNEL KCNE3; POTASSIUM CHANNEL KCNE5; POTASSIUM CHANNEL KCNQ1; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ACTION POTENTIAL; ARTICLE; CORRELATION ANALYSIS; GENE INACTIVATION; HEART FUNCTION; HEART REPOLARIZATION; HUMAN; INNER EAR; ION CONDUCTANCE; NONHUMAN; POINT MUTATION; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN DOMAIN; STIMULUS RESPONSE; ANIMAL CELL; CONDUCTANCE; CONFORMATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; MOLECULAR MODEL; OOCYTE; SIMULATION;

ACTION POTENTIALS; ALGORITHMS; ANIMALS; ELECTROPHYSIOLOGY; EXTRACELLULAR SPACE; ION CHANNEL GATING; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; KINETICS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RUBIDIUM; SODIUM; XENOPUS LAEVIS;

EID: 0142181060     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.046490     Document Type: Article

References (37)

1. Angelo K, Jespersen T, Grunnet M, Nielsen MS, Klaerke DA & Olesen SP (2002). KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current. Biophys J 83, 1997-2006.
2. Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M & Romey G (1996). K(V)LQT1 and 1sK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384, 78-80.
3. Biervert C, Schroeder BC, Kubisch C, Berkovic SF, Propping P, Jentsch TJ & Steinlein OK (1998). A potassium channel mutation in neonatal human epilepsy. Science 279, 403-406.
4. Charlier C, Singh NA, Ryan SG, Lewis TB, Reus BE, Leach RJ & Leppert M (1998). A pore mutation in a novel KQT-like potassium channel gene in an idiopathic epilepsy family. Nat Genet 18, 53-55.
5. Chen J, Seebohm G & Sanguinetti MC (2002). Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels. Proc Natl Acad Sci U S A 99, 12461-12466.
6. + channel. Proc Natl Acad Sci U S A 98, 12272-12277.
7. + conduction and selectivity. Science 280, 69-77.
8. Espinosa F, Fleischhauer R, McMahon A & Joho RH (2001). Dynamic interaction of S5 and S6 during voltage-controlled gating in a potassium channel. J Gen Physiol 118, 157-170.
9. Franqueza L, Lin M, Shen J, Splawski I, Keating MT & Sanguinetti MC (1999). Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. J Biol Chem 274, 21063-21070.
10. + channel signature sequence. Biophys J 66, 1061-1067.
11. Hille B (2001). Ion Channels of Excitable Membranes. Sinauer, Sunderland, MA, USA.
12. + channel. Nature 423, 33-41.
13. + channel. Nature 423, 42-48.
14. Kubisch C, Schroeder BC, Friedrich T, Lutjohann B, El-Amraoui A, Marlin S, Petit C & Jentsch TJ (1999). KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness. Cell 96, 437-446.
15. LeMasurier M, Heginbotham L & Miller C (2001). KcsA: it's a potassium channel. J Gen Physiol 118, 303-314.
16. + channel. Pflugers Arch 435, 654-661.
17. + selectivity filter. Nature 414, 37-42.
18. Pusch M (1998). Increase of the single-channel conductance of KvLQT1 potassium channels induced by the association with minK. Pflugers Arch 437, 172-174.
19. Pusch M, Bertorello L & Conti F (2000). Gating and flickery block differentially affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1 potassium channels. Biophys J 78, 211-226.
20. + channels. J Physiol 533, 135-143.
21. Pusch M, Magrassi R, Wollnik B & Conti F (1998). Activation and inactivation of homomeric KvLQT1 potassium channels. Biophys J 75, 785-792.
22. Saarinen K, Swan H, Kainulainen K, Toivonen L, Viitasalo M & Kontula K (1998). Molecular genetics of the long QT syndrome: two novel mutations of the KVLQT1 gene and phenotypic expression of the mutant gene in a large kindred. Hum Mutat 11, 158-165
23. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL & Keating MT (1996). Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384, 80-83.
24. + channels causes epilepsy. Nature 396, 687-690.
25. Schroeder BC, Waldegger S, Fehr S, Bleich M, Warth R, Greger R & Jentsch TJ (2000). A constitutively open potassium channel formed by KCNQ1 and KCNE3. Nature 403, 196-199.
26. Seebohm G, Scherer CR, Busch AE & Lerche C (2001). Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome. J Biol Chem 276, 13600-13605.
27. Sesti F & Goldstein SA (1998). Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome. J Gen Physiol 112, 651-663.
28. Shalaby FY, Levesque PC, Yang WP, Little WA, Conder ML, Jenkins-West T & Blanar MA (1997). Dominant-negative KvLQT1 mutations underlie the LQT1 form of long QT syndrome. Circulation 96, 1733-1736.
29. Splawski I, Shen J, Timothy KW, Lehmann MH, Priori S, Robinson JL, Moss AJ, Schwartz PJ, Towbin JA, Vincent GM & Keating MT (2000). Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation 102, 1178-1185.
30. Stühmer W (1998). Electrophysiologic recordings from Xenopus oocytes. Methods Enzymol 293, 280-300
31. Takumi T, Ohkubo H & Nakanishi S (1988). Cloning of a membrane protein that induces a slow voltage-gated potassium current. Science 242, 1042-1045.
32. Tapper AR & George AL Jr (2001). Location and orientation of minK within the I(Ks) potassium channel complex. J Biol Chem 276, 38249-38254.
33. Tinel N, Diochot S, Borsotto M, Lazdunski M & Barhanin J (2000). KCNE2 confers background current characteristics to the cardiac KCNQ1 potassium channel. EMBO J 19, 6326-6330.
34. + channel (minK) subunits. J Physiol 510, 37-45.
35. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, Vanraay TJ, Shen J, Timothy KW, Vincent GM, De Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD & Keating MT (1996). Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 12, 17-23.
36. Yang Y & Sigworth FJ (1998). Single-channel properties of IKs potassium channels. J Gen Physiol 112, 665-678.
37. Yellen G (2002). The voltage-gated potassium channels and their relatives. Nature 419, 35-42.