Single-channel characteristics of wild-type I(Ks) channels and channels formed with two MinK mutants that cause long QT syndrome

Journal of General Physiology

Volumn 112, Issue 6, 1998, Pages 651-663

  Sesti, Federico ^a   Goldstein, Steve A N ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Delayed rectifier; Heart; KvLQT1; Long QT syndrome; Potassium

Indexed keywords

MEMBRANE PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN MINK; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; GENE MUTATION; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; ION CONDUCTANCE; LONG QT SYNDROME; NONHUMAN; OOCYTE; XENOPUS LAEVIS;

ANIMALS; CHO CELLS; CRICETINAE; ELECTRIC CONDUCTIVITY; FEMALE; HUMANS; ION CHANNEL GATING; ION TRANSPORT; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; KINETICS; LONG QT SYNDROME; MEMBRANE POTENTIALS; MUTATION; OOCYTES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; XENOPUS LAEVIS;

EID: 0032435823     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.112.6.651     Document Type: Article

References (6)

1. Ackerman, M.J. 1998. The long QT syndrome: ion channel diseases of the heart. Mayo Clin. Proc. 73:250-269.
2. Barhanin, J., F. Lesage, E. Guillemare, M. Fink, M. Lazdunski, and G. Romey. 1996. K(V)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current. Nature. 384:78-80.
3. Doyle, D.A., J.M. Cabral, R.A. Pfuetzner, A.L. Kuo, J.M. Gulbis, S.L. Cohen, B.T. Chait, and R. Mackinnon. 1998. The structure of the potassium channel - molecular basis of K+ conduction and selectivity. Science. 280:69-77.
4. Wang, K.-W., K.-K. Tai, and S.A.N. Goldstein. 1996a. MinK residues line a potassium channel pore. Neuron. 16:571-577.
5. + channel mutations found in inherited cardiac arrhythmias. Hum. Mol. Genet. 6:1943-1949.
6. Ks potassium channels. J. Gen. Physiol. 112:665-678.