A structural basis for drug-induced long QT syndrome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 22, 2000, Pages 12329-12333

  Mitcheson, John S ^a,c   Chen, Jun ^a   Lin, Monica ^a   Culberson, Chris ^b   Sanguinetti, Michael C ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1' (6 CYANO 1,2,3,4 TETRAHYDRO 2 NAPHTHYL) 3,4 DIHYDRO 6 METHANESULFONAMIDOSPIRO[2H 1 BENZOPYRAN 2,4' PIPERIDIN] 4 OL; ANTIARRHYTHMIC AGENT; ANTIHISTAMINIC AGENT; CISAPRIDE; PROKINETIC AGENT; SULFANILAMIDE DERIVATIVE;

ANIMAL CELL; ARTICLE; DRUG BINDING; DRUG EFFECT; GENE MUTATION; HEART REPOLARIZATION; LONG QT SYNDROME; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CATION TRANSPORT PROTEINS; ETHER-A-GO-GO POTASSIUM CHANNELS; LONG QT SYNDROME; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS;

ANIMALIA; PHLEUM PRATENSE;

EID: 0034710933     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.210244497     Document Type: Article

References (33)

1. Keating, M. T. & Sanguinetti, M. C. (1996) Science 272, 681-685.
2. Curran, M. E., Splawski, I., Timothy, K. W., Vincent, G. M., Green, E. D. & Keating, M. T. (1995) Cell 80, 795-804.
3. Abbott, G. W., Sesti, F., Splawski, I., Buck, M. E., Lehmann, M. H., Timothy, K. W., Keating, M. T. & Goldstein, S. A. (1999) Cell 97, 175-187.
4. Sanguinetti, M. C., Jiang, C., Curran, M. E. & Keating, M. T. (1995) Cell 81, 299-307.
5. Trudeau, M., Warmke, J. W., Ganetzky, B. & Robertson, G. A. (1995) Science 269, 92-95.
6. Roden, D. M. (1998) Am. J. Cardiol. 82, 491-571.
7. El-Sherif, N. & Turitto, G. (2000) in Cardiac Electrophysiology from Cell to Bedside, eds. Zipes, D. P. & Jalife, J. (Saunders, Philadelphia), 3rd Ed., pp. 662-673.
8. Roden, D. M., Lazzara, R., Rosen, M., Schwartz, P. J., Towbin, J. & Vincent, G. M. (1996) Circulation 94, 1996-2012.
9. Crumb, W. & Cavero, I. (1999) Pharmaceut. Sci. Technol. 2, 270-280.
10. Pourrias, B., Porsalt, R. D. & Lacroix, P. (1999) Drug Dev. Res. 47, 55-62.
11. Ficker, E., Jarolimek, W., Kiehn, J., Baumann, A. & Brown, A. M. (1998) Circ. Res. 82, 386-395.
12. Lees-Miller, J. P., Duan, Y., Teng, G. Q. & Duff, H. J. (2000) Mol. Pharmacol. 57, 367-374.
13. Warmke, J. W. & Ganetzky, B. (1994) Proc. Natl. Acad. Sci. USA 91, 3438-3442.
14. Sanguinetti, M. C. & Xu, Q. P. (1999) J. Physiol. (London) 514, 667-675.
15. Goldin, A. L. (1991) Methods Cell Biol. 36, 487-509.
16. Goldin, A. L. & Sumikawa, K. (1992) Methods Enzymol. 207, 279-296.
17. Stuhmer, W. (1992) Methods Enzymol. 207, 319-339.
18. Mitcheson, J. S., Chen, J. & Sanguinetti, M. C. (2000) J. Gen. Physiol. 115, 229-240.
19. Doyle, D. A., Morais Cabral, J., Pfuetzner, R. A., Kuo, A., Gulbis, J. M., Cohen, S. L., Chait, B. T. & MacKinnon, R. (1998) Science 280, 69-77.
20. Miller, M. D., Kearsley, S. K., Underwood, D. J. & Sheridan, R. P. (1994) J. Comput. Aided Mol. Des. 8, 153-174.
21. Lynch, J. J., Wallace, A. A., Stupienski, R. F., 3rd, Baskin, E. P., Beare, C. M., Appleby, S. D., Salata, J. J., Jurkiewicz, N. K., Sanguinetti, M. C., Stein, R. B., et al. (1994) J. Pharmacol. Exp. Ther. 269, 541-554.
22. Zou, A., Curran, M. E., Keating, M. T. & Sanguinetti, M. C. (1997) Am. J. Physiol. 272, H1309-H1314.
23. Smith, P. L., Baukrowitz, T. & Yellen, G. (1996) Nature (London) 379, 833-836.
24. Wang, S., Morales, M. J., Liu, S., Strauss, H. C. & Rasmusson, R. L. (1996) FEBS Lett. 389, 167-173.
25. Mohammad, S., Zhou, Z., Gong, Q. & January, C. T. (1997) Am. J. Physiol. 42, H2534-H253.
26. Roy, M.-L., Dumaine, R. & Brown, A. M. (1996) Circ. Res. 94, 817-823.
27. Hockerman, G. H., Johnson, B. D., Scheuer, T. & Catterall, W. A. (1995) J. Biol. Chem. 270, 22119-22122.
28. Ragsdale, D. S., McPhee, J. C., Scheuer, T. & Catterall, W. A. (1996) Proc. Natl. Acad. Sci. USA 93, 9270-9275.
29. Hockerman, G. H., Johnson, B. D., Abbott, M. R., Scheuer, T. & Catterall, W. A. (1997) J. Biol. Chem. 272, 18759-18765.
30. Peterson, B. Z., Johnson, B. D., Hockerman, G. H., Acheson, M., Scheuer, T. & Catterall, W. A. (1997) J. Biol. Chem. 272, 18752-18758.
31. Wang, S., Morales, M. J., Liu, S., Strauss, H. C. & Rasmusson, R. L. (1997) FEBS Lett. 417, 43-47.
32. Spector, P. S., Curran, M. E., Keating, M. T. & Sanguinetti, M. C. (1996) Circ. Res. 78, 499-503.
33. del Camino, D., Holmgren, M., Liu, Y. & Yellen, G. (2000) Nature (London) 403, 321-325.